SF-NETT: San Francisco Neurological Emergencies Trials Network

SF-NETT：旧金山神经紧急试验网络

• 批准号: 8396945
• 负责人: JESSE Claude HEMPHILL
• 金额: $ 29.78万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-03 至 2017-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8396945
• 关键词: Acute; Alteplase; Ambulances; Brain; California; Caring; Cerebral Ischemia; Chairperson; Characteristics; Clinical; Clinical Research; Clinical Treatment; Clinical Trials; Community Hospitals; Destinations; Development; EMSA; Early treatment; Effectiveness; Emergency Medicine; Emergency Situation; Emergency treatment; Encephalitis; Enrollment; Ensure; Faculty; Fostering; Funding; General Hospitals; Goals; Hawaiian population; Heart Arrest; Heterogeneity; Hospitals; Hour; Human Resources; Interdisciplinary Study; Intervention; Ischemic Stroke; Latino; Learning; Logistics; Maintenance; Medical center; Meningitis; Minority; Modeling; National Institute of Neurological Disorders and Stroke; Nervous system structure; Neurological emergencies; Outcome; Pathway interactions; Patients; Phase; Phase III Clinical Trials; Physicians; Population; Population Heterogeneity; Public Health; Publishing; Refractory; Research; Research Infrastructure; Research Personnel; Research Subjects; San Francisco; Seizures; Standardization; Status Epilepticus; Stroke; System; Time; Tissues; Training; Transient Ischemic Attack; Traumatic Brain Injury; Underrepresented Minority; Universities; Work; Writing; acute stroke; base; career development; effective therapy; experience; flexibility; improved; member; multidisciplinary; neonatal hypoxic-ischemic brain injury; neuromuscular; next generation; programs; spinal cord and brain injury; trauma centers; treatment trial

DESCRIPTION (provided by applicant): Neurological emergencies comprise a wide range of conditions which include refractory seizures, acute stroke, traumatic brain and spinal cord injury, meningitis and encephalitis, hypoxic-ischemic encephalopathy, and acute neuromuscular conditions. While these may initially appear to represent disparate conditions, they share two important characteristics: earlier treatment is likely necessary to improve patient outcome and logistics of initial patient presentation pose major challenges to clinical trials of treatments fo these conditions. The NINDS Neurological Emergencies Treatment Trials Network has created a national network of hub and spoke hospital systems to facilitate the conduct of streamlined clinical trials for neurological emergencies such as these. SF-NETT: the San Francisco Neurological Emergencies Trials network has been a high-enrolling hub-spoke system during the first 5-year NETT cycle. SF-NETT represents a scalable and flexible network which can be configured and activated to maximize enrollment of eligible patients across a wide range of conditions being studied. Consisting of all San Francisco ambulance destination hospitals, as well as three specially selected geographically non-contiguous spokes (UCSF-Fresno, Queen's Medical Center, and UC Davis), SF-NETT represents a consortium of academic and community hospitals with a catchment population exceeding 4 million. San Francisco General Hospital is a trauma center, stroke center, the SF-EMSA base hospital, and serves as the hub of SF-NETT. Between the hub and participating spoke hospitals, there are 4 designated trauma centers, 7 comprehensive stroke centers, and 4 EMS systems. SF-NETT works directly with NINDS and the NETT Clinical Coordinating Center to conduct multiple concurrent clinical trials of neurological emergencies via the network, with four trials initiated (one completed) during the initial 5-year cycle. This application is for the 5-year renewal of SF-NETT as a hub for the national NETT network. PUBLIC HEALTH RELEVANCE: Neurological emergencies such as refractory seizures, stroke, and neurotrauma have a major impact on public health and are the challenging conditions to study because of the need for early intervention. The NETT network has proven to be an efficient system in which to conduct these trials and SF-NETT has been a high-enrolling active hub during the initial 5-year program cycle.

描述（由申请人提供）：神经急症包括范围广泛的情况，包括难治性癫痫发作，急性中风，创伤性脑和脊髓损伤，