SF-NETT: San Francisco Neurological Emergencies Trials Network

SF-NETT：旧金山神经紧急试验网络

• 批准号: 8726493
• 负责人: JESSE Claude HEMPHILL
• 金额: $ 30.93万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-03 至 2017-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8726493
• 关键词: Acute; Alteplase; Ambulances; Brain; California; Caring; Cerebral Ischemia; Chairperson; Characteristics; Clinical; Clinical Research; Clinical Treatment; Clinical Trials; Community Hospitals; Destinations; Development; EMSA; Early Intervention; Early treatment; Effectiveness; Emergency Medicine; Emergency Situation; Emergency treatment; Encephalitis; Enrollment; Ensure; Faculty; Fostering; Funding; General Hospitals; Goals; Hawaiian population; Heart Arrest; Heterogeneity; Hospitals; Hour; Human Resources; Interdisciplinary Study; Intervention; Ischemic Stroke; Latino; Learning; Logistics; Maintenance; Medical center; Meningitis; Minority; Modeling; National Institute of Neurological Disorders and Stroke; Nervous system structure; Neurological emergencies; Outcome; Pathway interactions; Patients; Phase; Phase III Clinical Trials; Physicians; Population; Population Heterogeneity; Public Health; Publishing; Refractory; Research; Research Infrastructure; Research Personnel; Research Subjects; San Francisco; Seizures; Standardization; Status Epilepticus; Stroke; System; Time; Tissues; Training; Transient Ischemic Attack; Traumatic Brain Injury; Underrepresented Minority; Universities; Work; Writing; acute stroke; base; career development; effective therapy; experience; flexibility; improved; member; multidisciplinary; neonatal hypoxic-ischemic brain injury; neuromuscular; next generation; programs; public health relevance; spinal cord and brain injury; trauma centers; treatment trial

DESCRIPTION (provided by applicant): Neurological emergencies comprise a wide range of conditions which include refractory seizures, acute stroke, traumatic brain and spinal cord injury, meningitis and encephalitis, hypoxic-ischemic encephalopathy, and acute neuromuscular conditions. While these may initially appear to represent disparate conditions, they share two important characteristics: earlier treatment is likely necessary to improve patient outcome and logistics of initial patient presentation pose major challenges to clinical trials of treatments fo these conditions. The NINDS Neurological Emergencies Treatment Trials Network has created a national network of hub and spoke hospital systems to facilitate the conduct of streamlined clinical trials for neurological emergencies such as these. SF-NETT: the San Francisco Neurological Emergencies Trials network has been a high-enrolling hub-spoke system during the first 5-year NETT cycle. SF-NETT represents a scalable and flexible network which can be configured and activated to maximize enrollment of eligible patients across a wide range of conditions being studied. Consisting of all San Francisco ambulance destination hospitals, as well as three specially selected geographically non-contiguous spokes (UCSF-Fresno, Queen's Medical Center, and UC Davis), SF-NETT represents a consortium of academic and community hospitals with a catchment population exceeding 4 million. San Francisco General Hospital is a trauma center, stroke center, the SF-EMSA base hospital, and serves as the hub of SF-NETT. Between the hub and participating spoke hospitals, there are 4 designated trauma centers, 7 comprehensive stroke centers, and 4 EMS systems. SF-NETT works directly with NINDS and the NETT Clinical Coordinating Center to conduct multiple concurrent clinical trials of neurological emergencies via the network, with four trials initiated (one completed) during the initial 5-year cycle. This application is for the 5-year renewal of SF-NETT as a hub for the national NETT network.

描述（由申请人提供）：神经系统急症包括各种各样的病症，包括难治性癫痫发作、急性中风、创伤性脑和脊髓损伤， 脑膜炎和脑炎、缺氧缺血性脑病和急性神经肌肉疾病。虽然这些可能最初似乎代表不同的条件，他们有两个重要的特点：早期治疗可能是必要的，以改善患者的结果和物流的初始患者介绍提出了重大挑战，这些条件的治疗的临床试验。NINDS神经系统紧急情况治疗试验网络创建了一个全国性的中心和辐射医院系统网络，以促进对此类神经系统紧急情况进行简化的临床试验。SF-NETT：旧金山弗朗西斯科神经系统紧急情况试验网络在第一个5年NETT周期内一直是一个高注册的中心辐射系统。SF-NETT代表了一个可扩展且灵活的网络，可以对其进行配置和激活，以最大限度地招募符合条件的患者。SF-NETT由所有旧金山弗朗西斯科救护目的地医院以及三个特别选择的地理位置不连续的辐条（UCSF-弗雷斯诺，皇后医疗中心和加州大学戴维斯分校）组成，代表了一个学术和社区医院联盟，服务人口超过400万。旧金山弗朗西斯科总医院是一个创伤中心，中风中心，SF-EMSA基地医院，并作为SF-NETT的枢纽。在中心医院和参与的分支医院之间，有4个指定的创伤中心，7个综合中风中心和4个EMS系统。SF-NETT直接与NINDS和NETT临床协调中心合作，通过网络进行多项神经系统紧急情况的并行临床试验，在最初的5年周期内启动了4项试验（其中一项已完成）。此申请是SF-NETT作为国家NETT网络中心的5年续约申请。