SF-NETT: San Francisco Neurological Emergencies Trials Network

描述(申请人提供)：神经急症包括多种情况，包括难治性癫痫发作、急性中风、创伤性脑和脊髓损伤、 脑膜炎和脑炎、缺氧缺血性脑病和急性神经肌肉疾病。虽然这些疾病最初看起来可能代表着不同的情况，但它们有两个重要的特征：早期治疗可能是改善患者预后所必需的，而最初患者表现的后勤工作给这些疾病的临床治疗试验带来了重大挑战。NINDS神经紧急情况治疗试验网络创建了一个由中心和辐射型医院系统组成的全国网络，以促进对此类神经紧急情况进行简化的临床试验。SF-NETT：旧金山神经紧急试验网络在第一个5年的NETT周期中一直是一个高注册率的中心辐射式系统。SF-NETT代表了一个可扩展和灵活的网络，可以配置和激活该网络，以最大限度地扩大正在研究的各种情况下符合条件的患者的人数。SF-NETT由旧金山所有救护车目的地医院以及三个特别挑选的地理上不连续的分支机构(加州大学旧金山分校-弗雷斯诺分校、女王医疗中心和加州大学戴维斯分校)组成，代表着一个学术和社区医院联盟，其覆盖人口超过400万。旧金山总医院是创伤中心、中风中心、SF-EMSA基地医院，也是SF-NETT的枢纽。在中心和参与的辐条医院之间，有4个指定的创伤中心，7个综合中风中心，和4个EMS系统。SF-NETT直接与NINDS和NETT临床协调中心合作，通过该网络进行多项同时进行的神经紧急情况临床试验，在最初的5年周期中启动了4项试验(1项已完成)。本申请是为作为全国NETT网络枢纽的SF-NETT续展5年。

DESCRIPTION (provided by applicant): Neurological emergencies comprise a wide range of conditions which include refractory seizures, acute stroke, traumatic brain and spinal cord injury, meningitis and encephalitis, hypoxic-ischemic encephalopathy, and acute neuromuscular conditions. While these may initially appear to represent disparate conditions, they share two important characteristics: earlier treatment is likely necessary to improve patient outcome and logistics of initial patient presentation pose major challenges to clinical trials of treatments fo these conditions. The NINDS Neurological Emergencies Treatment Trials Network has created a national network of hub and spoke hospital systems to facilitate the conduct of streamlined clinical trials for neurological emergencies such as these. SF-NETT: the San Francisco Neurological Emergencies Trials network has been a high-enrolling hub-spoke system during the first 5-year NETT cycle. SF-NETT represents a scalable and flexible network which can be configured and activated to maximize enrollment of eligible patients across a wide range of conditions being studied. Consisting of all San Francisco ambulance destination hospitals, as well as three specially selected geographically non-contiguous spokes (UCSF-Fresno, Queen's Medical Center, and UC Davis), SF-NETT represents a consortium of academic and community hospitals with a catchment population exceeding 4 million. San Francisco General Hospital is a trauma center, stroke center, the SF-EMSA base hospital, and serves as the hub of SF-NETT. Between the hub and participating spoke hospitals, there are 4 designated trauma centers, 7 comprehensive stroke centers, and 4 EMS systems. SF-NETT works directly with NINDS and the NETT Clinical Coordinating Center to conduct multiple concurrent clinical trials of neurological emergencies via the network, with four trials initiated (one completed) during the initial 5-year cycle. This application is for the 5-year renewal of SF-NETT as a hub for the national NETT network.