SF-NET: San Francisco Neurological Emergencies Trials Network

SF-NET：旧金山神经紧急试验网络

• 批准号: 8069147
• 负责人: JESSE Claude HEMPHILL
• 金额: $ 19.41万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-03 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8069147
• 关键词: Acute; Ambulances; Area; Brain; Caring; Catchment Area; Cerebral hemisphere hemorrhage; Characteristics; Clinical; Clinical Research; Clinical Treatment; Clinical Trials; Collaborations; Communities; Community Hospitals; Community Practice; Comprehensive Health Care; Contracts; County; Destinations; Development; Documentation; EMSA; Early treatment; Education; Emergency Medicine; Emergency Situation; Emergency medical service; Emergency treatment; Encephalitis; Enrollment; Failure; General Hospitals; Health Personnel; Heterogeneity; Hospital Personnel; Hospitals; Individual; Institutional Review Boards; Intervention; Ischemic Stroke; Logistics; Medical center; Meningitis; Modeling; National Institute of Neurological Disorders and Stroke; Neurological emergencies; Neurologist; Neurosurgeon; Outcome; Paramedical Personnel; Patients; Phase III Clinical Trials; Physicians; Protocols documentation; Public Health; Refractory; Research; Research Infrastructure; Research Personnel; San Francisco; Science; Seizures; Services; Status Epilepticus; Stroke; System; Therapeutic; Time; Traumatic Brain Injury; Work; acute stroke; base; cell injury; clinical care; clinical practice; clinical research site; flexibility; functional outcomes; improved; neonatal hypoxic-ischemic brain injury; nervous system disorder; neuromuscular; research study; response; spinal cord and brain injury; success; trauma centers; treatment trial

DESCRIPTION (provided by applicant): Neurological emergencies comprise a wide range of conditions which include refractory seizures, acute stroke, traumatic brain and spinal cord injury, meningitis and encephalitis, hypoxic-ischemic encephalopathy, and acute neuromuscular conditions. While these may initially appear to represent disparate conditions, they share two important characteristics: earlier treatment is likely necessary to improve patient outcome and logistics of initial patient presentation pose major challenges to clinical trials of treatments for these conditions. The NINDS Neurological Emergencies Treatment Trials Network will create a national network of hub and spoke hospital systems to facilitate the conduct of streamlined clinical trials for neurological emergencies such as these. We propose SF-NET: the San Francisco Neurological Emergencies Trials network as one of these hub and spoke systems. SF-NET represents a scalable and flexible network of academic and community hospitals which can be configured and activated to maximize enrollment of eligible patients with neurological emergencies in the San Francisco Bay Area, completely covering a catchment area of up to 2 million people depending on the specific condition to be studied. SF-NET builds directly upon the prior successes of clinical trials for neurological emergencies conducted in San Francisco, most prominently the Prehospital Treatment of Status Epilepticus (PHTSE) trial which was conducted via a similar type of network in coordination with SF-EMSA paramedic and ambulance services. San Francisco General Hospital is a trauma center, stroke center, the SF-EMSA base hospital, and serves as the hub of SF-NET. Spoke hospitals include all eight SF-EMSA destination hospitals in San Francisco, all of which previously participated in PHTSE, as well as Alameda County Medical Center Highland Hospital, the trauma center in Oakland, included to enrich SF-NET in neurotrauma. SF-NET will work directly with NINDS and the NETT Clinical Coordinator Center to conduct at least 2 clinical trials of neurological emergencies via the network. Neurological emergencies such as refractory seizures, stroke, and neurotrauma have a major impact on public health and are challenging conditions to study because of the need for early intervention. A network to conduct streamlined trials for these conditions can bring new treatments to clinical care more rapidly.

描述(申请人提供)：神经急症包括多种情况，包括难治性癫痫、急性中风、创伤性脑和脊髓损伤、脑膜炎和脑炎、缺氧缺血性脑病和急性神经肌肉疾病。虽然这些疾病最初看起来可能代表着不同的情况，但它们有两个重要的特征：早期治疗可能是改善患者结局所必需的，而最初患者表现的后勤工作给这些疾病的临床治疗试验带来了重大挑战。NINDS神经紧急情况治疗试验网络将创建一个由中心和分支医院系统组成的全国网络，以促进对此类神经紧急情况进行简化的临床试验。我们提出了SF-Net：旧金山神经紧急试验网络作为这些中心和分支系统之一。SF-Net代表了一个可扩展的灵活的学术和社区医院网络，可以配置和激活该网络，以最大限度地扩大旧金山湾区符合条件的神经紧急情况患者的招生人数，完全覆盖多达200万人的覆盖区域，具体取决于要研究的具体情况。SF-Net直接建立在旧金山进行的神经紧急情况临床试验之前的成功基础上，最突出的是通过与SF-EMSA护理和救护车服务协调的类似类型的网络进行的癫痫持续状态的院前治疗(PHTSE)试验。旧金山总医院是创伤中心、中风中心、SF-EMSA基地医院，是SF-Net的枢纽。发言医院包括旧金山的所有八家SF-EMSA目的地医院，所有这些医院都曾参加过PHTSE，以及奥克兰的创伤中心阿拉米达县医疗中心高地医院，包括在内以丰富SF-Net在神经创伤方面的内容。SF-Net将直接与NINDS和NETT临床协调中心合作，通过该网络进行至少2项神经紧急情况的临床试验。神经突发事件，如难治性癫痫、中风和神经创伤，对公共健康有重大影响，由于需要早期干预，研究条件具有挑战性。一个对这些疾病进行简化试验的网络可以更快地将新的治疗方法带到临床护理中。