Training in Developmental Hematology

描述（由申请人提供）：儿童血液疾病的研究为理解调节造血的基本机制提供了一个重要的范例。与成人血液病不同，许多儿童疾病是由控制血细胞发育或功能的内在遗传缺陷引起的。对许多儿童血液病的分子发病机制了解甚少。在加州大学洛杉矶分校，我们拥有丰富的跨学科研究人员资源，他们的研究重点是与发育血液学相关的广泛主题。因此，我们提出了一个独特的培训计划，通过整合各种学科，包括分子和细胞造血，替代生物模型，干细胞移植，止血和血栓形成，输血医学，蛋白质组学/基因组学的新技术，血液恶性肿瘤，治疗学和数学建模，专门针对儿科血液病。鉴于儿科血液学的医师科学家数量下降，发展血液学的培训计划对推进该领域至关重要。在此申请中，我们每年寻求资助4名博士后，为期5年。这些研究员要么是医学博士，要么是医学博士/博士，要么是博士。受训者将有机会在22名教员的实验室之一开展研究。研修生将根据其学术潜力和研究成果从大约20至30名博士后中选拔。任用将为期两年，第二年的任用视进度报告而定。学员将被要求参加多学科期刊俱乐部、凝血课程和研讨会。他们还将通过病理学部门学习一门关于发育血液学的必修课。儿科血液学/肿瘤学学员将每6个月与他们的奖学金监督委员会会面，以监督进展和生产力。他们将在全国会议上介绍他们的工作。许多研究者已经有了合作和出版物。我们希望利用UCLA的优势，包括跨学科研究人员的广度和深度，培养未来儿科血液学领域的研究人员和领导者。

DESCRIPTION (provided by applicant): Studies in pediatric blood disorders provide an important paradigm for understanding the fundamental mechanisms regulating hematopoiesis. Unlike adult hematologic disorders, many pediatric diseases result from intrinsic genetic defects that control blood cell development or function. Very little is understood about the molecular pathogenesis of many of the hematologic diseases in children. At UCLA, we have a tremendous resource of interdisciplinary investigators whose research focuses on a wide spectrum of topics related to developmental hematology. Therefore, we propose a unique training program that focuses specifically on pediatric hematologic diseases by integrating a variety of disciplines, including molecular and cellular hematopoiesis, alternative organism models, stem cell transplantation, hemostasis and thrombosis, transfusion medicine, novel technologies in proteomics/genomics, hematologic malignancies, therapeutics, and mathematical modeling. Given the declining number of physician-scientists in Pediatric Hematology, a training program in Developmental Hematology is critical to advance the field. In this application, we seek funding for 4 postdoctoral fellows per year for 5 years. The fellows will be either MDs, MD/PhDs, or PhDs. Trainees will have the opportunity to develop research in one of the 22 faculty member's laboratories. Trainees will be selected from a pool of approximately 20 to 30 postdoctoral fellows based on their academic potential and research achievements. Appointments will be for two years, the second year appointment being dependent on a progress report. Trainees will be required to participate in multidisciplinary journal clubs, a course on coagulation, and seminars. They will also take a required course on Developmental Hematology through the Department of Pathology. Pediatric Hematology/Oncology trainees will be expected to meet with their Scholarship Oversight Committees every 6 months to monitor progress and productivity. They will present their work at national meetings. Many investigators have pre- existing collaborations and publications. We hope to utilize the strengths of UCLA, including the breadth and depth of investigators across many disciplines, to train future researchers and leaders in the field of Pediatric Hematology.