Training in Developmental Hematology

项目总结/摘要 儿科血液疾病的研究为理解血液疾病的基本原理提供了一个重要的范例。 调节造血的机制。与成人血液系统疾病不同，许多儿科疾病导致 来自控制血细胞发育或功能的内在遗传缺陷。理解依然 对大多数儿童血液病的分子发病机制的研究尚不完整。在加州大学洛杉矶分校， 一个跨学科研究人员的巨大资源，其研究集中在广泛的主题 与发育血液学有关鉴于儿科医生科学家数量的下降， 血液学，发育血液学的培训计划对于培养研究者骨干至关重要 他将继续推动这一领域的发展。因此，我们提出了一个独特的培训计划， 特别是儿科血液病，通过整合各种学科，包括分子和 细胞造血，替代生物模型，干细胞移植和基因治疗，止血 和血栓形成，输血医学，新技术（基因组学，蛋白质组学，基因编辑等）， 血液恶性肿瘤、治疗学和生物信息学。在这个应用程序中，我们寻求资金4 博士后研究员每年5年。研究员将是最近获得MD，MD/PhD或PhD的人 正在接受博士后培训。我们将强调招聘，以反映性别，种族， 我们民族的多样性。学员将有机会在22个学院之一开展研究 成员的实验室，桥梁12个部门，提供学员获得令人难以置信的多样化 加州大学洛杉矶分校校园的学术资产。指导教师有积极和富有成效的研究 课程和多个相互合作和出版物，提供了一个理想的培训环境。 学员还可以参加与NHLBI资助的T32项目在 密歇根大学（HL 007622），以获得止血/血栓形成或 造血干细胞移植，他们的计划的两个学术优势（UM学员可以来 加州大学洛杉矶分校的细胞和基因治疗培训）。学员将从大量博士后研究员中挑选 根据他们的学术和研究成果。实习期为1-2年，第二年 任命取决于记录的生产力。学员将参加一个关于发展的必修课程 血液学，并接受人体受试者研究原则和负责任行为的培训 通过研究伦理课程进行研究。他们将参加期刊俱乐部，参加研讨会， 与儿科血液学、干细胞生物学、免疫学和临床研究相关的讲座。学员将 每6个月与奖学金监督委员会会面，以监督进度和生产力。我们将 利用加州大学洛杉矶分校的优势，包括跨许多学科的调查人员的广度和深度， 儿科血液学领域的未来研究人员和领导者。

PROJECT SUMMARY/ABSTRACT Studies in pediatric blood disorders provide an important paradigm for understanding the fundamental mechanisms regulating hematopoiesis. Unlike adult hematologic disorders, many pediatric diseases result from intrinsic genetic defects that control blood cell development or function. Understanding remains incomplete on the molecular pathogenesis of most of the hematologic diseases in children. At UCLA, we have a tremendous resource of interdisciplinary investigators whose research focuses on a wide spectrum of topics related to developmental hematology. Given the declining number of physician-scientists in Pediatric Hematology, a training program in Developmental Hematology is critical to produce the cadre of investigators who will continue to advance the field. Therefore, we propose a unique training program that focuses specifically on pediatric hematologic diseases by integrating a variety of disciplines, including molecular and cellular hematopoiesis, alternative organism models, stem cell transplantation and gene therapy, hemostasis and thrombosis, transfusion medicine, novel technologies (genomics, proteomics, gene editing, etc.), hematologic malignancies, therapeutics, and bioinformatics. In this application, we seek funding for 4 postdoctoral fellows per year for 5 years. The fellows will be either recent recipients of MD, MD/PhD, or PhD degrees undergoing postdoctoral training. We will emphasize recruitment to reflect the gender, racial, and ethnic diversity of our nation. Trainees will have the opportunity to develop research in one of the 22 faculty member's laboratories that bridge 12 Departments, providing trainees access to the incredibly diverse academic assets across the UCLA campus. The mentoring faculty have active and productive research programs and multiple mutual collaborations and publications, providing an ideal training environment. Trainees may also participate in an exchange program established with the NHLBI-funded T32 program at the University of Michigan (HL007622) to gain deeper knowledge of either hemostasis/thrombosis or hematopoietic stem cell transplantation, two academic strengths of their program (UM trainees may come to UCLA for training in cell and gene therapy). Trainees will be selected from a large pool of postdoctoral fellows based on their academic and research achievements. Appointments will be for 1-2 years, the second year appointment dependent on documented productivity. Trainees will take a required course on Developmental Hematology and receive training in principles of human subject research and the responsible conduct of research through courses in research ethics. They will participate in journal clubs and attend seminars and lectures related to pediatric hematology, stem cell biology, immunology and clinical research. Trainees will meet with a Scholarship Oversight Committee every 6 months to monitor progress and productivity. We will utilize the strengths of UCLA, including the breadth and depth of investigators across many disciplines, to train future researchers and leaders in the field of Pediatric Hematology.