LENTIVIRAL VECTOR FOR GENE TRANSFER TO HEMATOPOIETIC STEM CELLS

用于基因转移至造血干细胞的慢病毒载体

• 批准号: 7958998
• 负责人: Donald B Kohn
• 金额: $ 14.23万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7958998
• 关键词: Autologous; Behavior Therapy; Bone Marrow Transplantation; Busulfan; California; Computer Retrieval of Information on Scientific Projects Database; Funding; Gene Transfer; Grant; Hematopoietic stem cells; Human; Institution; Lentivirus Vector; Primates; Research; Research Personnel; Resources; Source; Stem cells; Transplantation; United States National Institutes of Health; conditioning; cytotoxic

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. These studies focus on conditioning therapy (busulfan) for transplant of autologous transduced hematopoietic stem cells. Busulfan produces a specific loss of early stem cells and has been used as a stem cell cytotoxic conditioning agent prior to bone marrow transplantation in humans.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这些研究主要集中在自体转导的造血干细胞移植的条件性治疗(白头翁)。白花丹会产生早期干细胞的特异性损失，并在人类骨髓移植之前被用作干细胞细胞毒调节剂。