Evaluation of a Lifestyle Intervention for Employees with Prediabetes

描述（由申请人提供）：在美国，大约40%的人口患有某种高血糖症。工作场所干预措施为向糖尿病前期患者提供公共卫生干预措施提供了一个有希望的框架，因为工作场所在成年后的大部分时间里都能接触到很大一部分人口。通过工作场所进行长期随访和支持的机会可能比通过诊所或社区计划更大。雇员和雇主在保持劳动力的健康和控制医疗保健费用方面都有既得利益。因此，本研究的目的是在俄亥俄州州立大学（OSU）18-65岁的糖尿病前期成人（n=76）中评价工作场所干预与常规护理相比的影响。OSU是美国第二大公立大学，包括一个一流的医疗中心。参与者将被随机分配到一个为期16周的，基于小组的，在工作场所提供的生活方式干预或常规护理。16周的基于小组的干预，改编自糖尿病预防计划，强调减少膳食脂肪和能量摄入，以及每周至少150分钟的适度体力活动。将确定干预对体重变化百分比（主要结局）、空腹血糖、血脂、血压、体重参数、饮食摄入（通过食物频率问卷评估）、体力活动、生活质量以及与问题解决和目标设定理论相关的结构的影响，并将其与干预后和3个月随访时的常规护理进行比较。这项研究的结果将使研究人员能够完善招聘策略和干预程序，为糖尿病前期员工开发一个潜在的可持续的大学计划，以进行更大规模的转化临床试验。 公共卫生相关性：工作场所的干预措施提供了一个有前途的框架，提供更多的照顾糖尿病前期的人，因为工作场所达到了成年人口的很大一部分。旨在促进减肥的结构化生活方式干预的效果 和预防2型糖尿病相比，通常的护理将被确定。研究结果将被用来提供一个有效的干预，可以通过大学工地设置持续的员工。

DESCRIPTION (provided by applicant): In the U.S., approximately 40% of the population has some hyperglycemic condition. Worksite interventions offer a promising framework for delivering public health interventions to people with prediabetes, since worksites reach a large segment of the population for most of their adult life. The opportunity for long-term follow-up and support may be greater through worksites than through clinic- or community-based programs. Both the employee and employer have a vested interest in maintaining the health of the workforce and controlling health care costs. Therefore, the purpose of this study is to evaluate the impact of a worksite intervention compared to usual care among adults aged 18-65 years with prediabetes (n=76) at The Ohio State University (OSU). OSU is the second largest public university in the U.S. and includes a premier medical center. Participants will be randomly assigned to either a 16-week, group-based, lifestyle intervention delivered at the worksite or to usual care. The 16-week group- based intervention, adapted from the Diabetes Prevention Program, emphasizes reduction in dietary fat and energy intake and at least 150 minutes/week of moderate physical activity. The impact of the intervention on percent change in weight (primary outcome), fasting glucose, lipid panel, blood pressure, weight parameters, dietary intake (via food frequency questionnaire assessment), physical activity, quality of life, and constructs related to problem solving and goal setting theories will be determined and compared to usual care post-intervention and at 3-month follow-up. The findings from this study will enable the investigators to refine recruitment strategies and intervention procedures to develop a potentially sustainable university-based program for employees with prediabetes for a larger translational clinical trial. PUBLIC HEALTH RELEVANCE: Worksite interventions offer a promising framework for delivering greater care to people with prediabetes, since worksites reach a large segment of the adult population. The effect of a structured lifestyle intervention designed to promote weight loss and prevent type 2 diabetes compared to usual care will be determined. The findings will be used to deliver an effective intervention to employees that can be sustained through university worksite settings.