Center for Integrative Research on Childhood Leukemia and the Environment

儿童白血病与环境综合研究中心

• 批准号: 8309468
• 负责人: Patricia A Buffler
• 金额: $ 73.78万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-25 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8309468
• 关键词: ABCB1 gene; Advisory Committees; Advocate; Biological; Biological Markers; Birth; Blood; Blood specimen; CYP1A1 gene; California; Cancer Etiology; Carcinogen exposure; Carcinogens; Cell Differentiation process; Chemicals; Child; Childhood; Childhood Leukemia; Communities; Community Outreach; Cytogenetics; DNA Methylation; Data; Development; Disease; EPHX1 gene; Environment; Environmental Exposure; Environmental Health; Epidemiologic Studies; Epigenetic Process; Etiology; Event; Exposure to; Faculty; GSTM1 gene; GSTP1 gene; GSTT1 gene; Genes; Genetic; Genetic Polymorphism; Genetic Variation; Health; Hematopoietic; Histologic; Home environment; House Dust; Household; Individual; Interdisciplinary Study; International; Interview; Investigation; Leadership; Measures; Meta-Analysis; Methods; Methylation; Neonatal; Newborn Infant; Parents; Pathogenesis; Patient Self-Report; Pattern; Pesticides; Pharmaceutical Preparations; Phenotype; Play; Policies; Polychlorinated Biphenyls; Population; Process; Public Health; Research; Research Personnel; Research Project Grants; Research Support; Risk; Role; Sampling; Series; Serum; Smoking; Specialist; Specimen; Spottings; Structure; Time; Tobacco; Tobacco smoking; Translational Research; Universities; Work; Xenobiotics; adduct; base; career development; case control; data management; design; early life exposure; epidemiology study; genetic epidemiology; improved; in utero; interest; leukemia; outreach; pesticide exposure; phenyl ether; postnatal; prenatal exposure; programs; protein profiling; tobacco exposure

Description (provided by applicant): The proposed new Children's Environmental Health Center based at the University of California, Berkeley is designed to examine the effects of in utero and early life exposure to potentially carcinogenic chemicals present in homes (i.e., pesticides, tobacco-related and epigenetic factors and their interplay in the development of childhood leukemia. The proposed Center, referred to as Center for Interdisciplinary Research on Childhood Leukemia and the Environment (CIRCLE) includes three Research Projects and two Cores as follows: Project 1 (Childhood Leukemia International Consortium Studies) will identify the exposures to the most relevant time periods and childhood leukemia subtypes and identify important genetic polymorphisms that can modify the association between childhood leukemia and parental tobacco smoking or home pesticide exposure by pooling data from 19 studies worldwide; Project 2 (Exposure Assessment for Childhood Leukemia) y\/ill assess carcinogen exposures, based upon analysis of house dust and blood specimens, with special interest in tobacco-related contaminants, PCBs, and PBDEs; Project 3 (Prenatal exposures, DNA Methylation, & Childhood Leukemia) will provide a clearer understanding of the association between parental smoking, pesticides, PCBs, PBDEs exposures and DNA methylation patterns in childhood leukemia, using neonatal bloods. The Research Translation and Community Outreach Core (RTCO Core) will disseminate findings from each Project to various audiences with common interest in the etiology of childhood leukemia. The main objectives of Core A are to provide 1) oversight, coordination, and integration of Center activities; 2) scientific leadership; and 3) centralized data management support. Core A will establish and manage Internal and External Advisory Committees; appoint and collaborate with two Pediatric Health Specialists, and support the research career development of new, junior faculty-level investigators within the structure of the Center. Core A will coordinate Community Engagement through the RTCO Core, assisted by the pediatric Health Specialists.

描述（由申请人提供）：拟建的新儿童环境健康中心位于加州大学伯克利分校，旨在研究子宫内和生命早期暴露于家庭中存在的潜在致癌化学物质（即农药、烟草相关因素和表观遗传因素及其在儿童白血病发展中的相互作用）的影响。该中心被称为儿童白血病与环境跨学科研究中心（CIRCLE），包括以下三个研究项目和两个核心：项目1（儿童白血病国际联盟研究）将通过汇集全球19项研究的数据，确定最相关时间段的暴露和儿童白血病亚型，并确定可以改变儿童白血病与父母吸烟或家庭农药暴露之间关系的重要遗传多态性；项目2（儿童白血病暴露评估）将根据对室内灰尘和血液样本的分析评估致癌物暴露，特别关注与烟草有关的污染物、多氯联苯和多溴二苯醚；项目3（产前暴露、DNA甲基化和儿童白血病）将利用新生儿血液，更清楚地了解父母吸烟、杀虫剂、多氯联苯、多溴二苯醚暴露与儿童白血病DNA甲基化模式之间的关系。研究翻译和社区外展核心（RTCO核心）将把每个项目的研究结果传播给对儿童白血病病因感兴趣的各种受众。核心A的主要目标是：1)监督、协调和整合中心的活动；2)科学领导；3)集中的数据管理支持。核心A将设立和管理内部和外部咨询委员会；任命并与两名儿科健康专家合作，并支持中心结构内新的初级教员级研究人员的研究职业发展。核心A将在儿科保健专家的协助下，通过区域卫生组织核心协调社区参与。