Center for Integrative Research on Childhood Leukemia and the Environment

儿童白血病与环境综合研究中心

• 批准号: 7939617
• 负责人: Patricia A Buffler
• 金额: $ 73.53万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-25 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7939617
• 关键词: Advisory Committees; Arts; Blood; Blood specimen; California; Cancer Etiology; Carcinogen exposure; Chemicals; Child; Childhood; Childhood Leukemia; Communities; Community Outreach; DNA Methylation; Development; Environment; Environmental Health; Epidemiologic Studies; Epigenetic Process; Etiology; Exposure to; Faculty; Genetic Polymorphism; Health; Home environment; House Dust; Interdisciplinary Study; International; Leadership; Measures; Meta-Analysis; Methods; Neonatal; Pattern; Pesticides; Play; Polychlorinated Biphenyls; Research; Research Personnel; Research Project Grants; Research Support; Risk; Role; Smoking; Specialist; Structure; Time; Tobacco; Tobacco smoking; Translational Research; Universities; Work; base; career development; data management; design; early life exposure; in utero; interest; outreach; pesticide exposure; prenatal exposure; programs

Description (provided by applicant): The proposed new Children's Environmental Health Center based at the University of California, Berkeley is designed to examine the effects of in utero and early life exposure to potentially carcinogenic chemicals present in homes (i.e., pesticides, tobacco-related and epigenetic factors and their interplay in the development of childhood leukemia. The proposed Center, referred to as Center for Interdisciplinary Research on Childhood Leukemia and the Environment (CIRCLE) includes three Research Projects and two Cores as follows: Project 1 (Childhood Leukemia International Consortium Studies) will identify the exposures to the most relevant time periods and childhood leukemia subtypes and identify important genetic polymorphisms that can modify the association between childhood leukemia and parental tobacco smoking or home pesticide exposure by pooling data from 19 studies worldwide; Project 2 (Exposure Assessment for Childhood Leukemia) y\/ill assess carcinogen exposures, based upon analysis of house dust and blood specimens, with special interest in tobacco-related contaminants, PCBs, and PBDEs; Project 3 (Prenatal exposures, DNA Methylation, & Childhood Leukemia) will provide a clearer understanding of the association between parental smoking, pesticides, PCBs, PBDEs exposures and DNA methylation patterns in childhood leukemia, using neonatal bloods. The Research Translation and Community Outreach Core (RTCO Core) will disseminate findings from each Project to various audiences with common interest in the etiology of childhood leukemia. The main objectives of Core A are to provide 1) oversight, coordination, and integration of Center activities; 2) scientific leadership; and 3) centralized data management support. Core A will establish and manage Internal and External Advisory Committees; appoint and collaborate with two Pediatric Health Specialists, and support the research career development of new, junior faculty-level investigators within the structure of the Center. Core A will coordinate Community Engagement through the RTCO Core, assisted by the pediatric Health Specialists.

描述（由申请人提供）：拟议的位于加州大学伯克利分校的新儿童环境健康中心旨在研究子宫内和生命早期接触家庭中存在的潜在致癌化学物质（即农药、烟草相关和表观遗传因素及其在儿童白血病发展中的相互作用）的影响。拟议的中心称为儿童跨学科研究中心 白血病与环境 (CIRCLE) 包括三个研究项目和两个核心项目，如下：项目 1（儿童白血病国际联盟研究）将通过汇集全球 19 项研究的数据，确定最相关的时间段和儿童白血病亚型的暴露情况，并确定可以改变儿童白血病与父母吸烟或家庭杀虫剂暴露之间关联的重要遗传多态性；项目2（曝光 儿童白血病评估）您将根据对室内灰尘和血液样本的分析来评估致癌物暴露，特别关注与烟草相关的污染物、多氯联苯和多溴联苯醚；项目 3（产前暴露、DNA 甲基化和儿童白血病）将更清楚地了解父母吸烟、农药、多氯联苯、多溴联苯醚暴露与 DNA 之间的关联 使用新生儿血液研究儿童白血病的甲基化模式。研究翻译和社区外展核心（RTCO 核心）将向对儿童白血病病因学有共同兴趣的不同受众传播每个项目的研究结果。核心 A 的主要目标是： 1) 中心活动的监督、协调和整合； 2）科学领导； 3）集中数据管理支持。核心A将建立和管理内部和外部咨询委员会；任命两名儿科健康专家并与之合作，并支持中心结构内新的初级教职人员研究人员的研究职业发展。核心 A 将在儿科健康专家的协助下通过 RTCO 核心协调社区参与。