Parsimonious Models for Survival Data

生存数据的简约模型

基本信息

  • 批准号:
    8394875
  • 负责人:
  • 金额:
    $ 15万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2012
  • 资助国家:
    美国
  • 起止时间:
    2012-09-14 至 2014-02-28
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): This Small Business Innovation Research project addresses the problem of biomarker detection in clinical and high-throughput data. The objective is to investigate new approaches for deter- mining, from data consisting of many possibly irrelevant or redundant measurements, a highly predictive and interpretable model that involves only a small number of measurements. These new methods will be studied for modeling subjects' time-to-event (such as stroke, heart attack, or metastasis in cancer). The proposed approaches will be compared with existing methods that attempt to use relatively few mea- surements in modeling survival (time-to-event) data. The data to be analyzed will include ion-mobility and clinical data from a large cardiovascular disease cohort, as well as high-throughput genomic data from cancer research with many more measurements than samples. Relevance. Although today's advanced technologies offer the possibility of revolutionizing clinical practice, the analytical tools available for extracting information from this amount of daa are not yet sufficiently developed for targeted exploration of the underlying biology. This project directly addresses the need to make what the FDA terms IVDMIA (In-Vitro Diagnostic Multivariate Index Assays) transparent and interpretable, and is thus an opportunity to improve analysis services or products provided to companies that identify, characterize, and validate biomarkers for clinical diagnostics and drug development decision points. The proposed project will produce robust methods for parsimonious biomarker detection that will speed the development of cheaper and more effective diagnostic tests for disease diagnosis, treatment monitoring, and therapeutic drug development. PUBLIC HEALTH RELEVANCE: There is a great need in medical research for prognostic models that can accurately predict time to an event, such as a heart attack, from a few observed features. These models can be used in establishing new diagnostic and screening tests, and in advancing new therapies. New methods for time-to-event modeling are proposed that will speed the development of cheaper and more effective clinical support systems, and have a far-reaching impact on public health.
描述(由申请人提供):这个小型企业创新研究项目解决了临床和高通量数据中的生物标记物检测问题。我们的目标是研究新的方法,从由许多可能不相关或冗余的测量组成的数据中,挖掘一个只涉及少量测量的高度预测和可解释的模型。这些新方法将被用于对受试者的事件发生时间(如中风、心脏病发作或癌症转移)进行建模。建议的方法将与现有的方法进行比较,现有方法试图使用相对较少的方法来模拟生存(事件发生时间)数据。要分析的数据将包括离子迁移率和来自一大批心血管疾病队列的临床数据,以及来自癌症研究的高通量基因组数据,这些数据的测量比样本多得多。关联性。尽管今天的先进技术为临床实践提供了革命性的可能性,但可用于从如此数量的DAA中提取信息的分析工具还没有充分开发出来,以有针对性地探索潜在的生物学。这个项目 直接解决了FDA所称的IVDMIA(体外诊断多元指数分析)透明和可解释的需求,从而为识别、表征和验证临床诊断和药物开发决策点的生物标记物的公司提供了一个改善分析服务或产品的机会。拟议的项目将产生用于简约生物标记物检测的强大方法,这将加速开发更便宜、更有效的诊断测试,用于疾病诊断、治疗监测和治疗药物开发。 公共卫生相关性:在医学研究中,非常需要能够根据几个观察到的特征准确预测事件发生时间的预后模型。这些模型可以用于建立新的诊断和筛查测试,以及推进新的治疗方法。提出了事件间隔时间建模的新方法,这将加速开发更便宜、更有效的临床支持系统,并对公众健康产生深远的影响。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Chris Fraley其他文献

Chris Fraley的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Chris Fraley', 18)}}的其他基金

Reproducibility Assessment for Multivariate Assays
多变量测定的重现性评估
  • 批准号:
    8647816
  • 财政年份:
    2014
  • 资助金额:
    $ 15万
  • 项目类别:
Parsimonious Models for Survival Data
生存数据的简约模型
  • 批准号:
    8545192
  • 财政年份:
    2012
  • 资助金额:
    $ 15万
  • 项目类别:
Least Angle Regression
最小角回归
  • 批准号:
    7748342
  • 财政年份:
    2005
  • 资助金额:
    $ 15万
  • 项目类别:
Least Angle Regression
最小角回归
  • 批准号:
    7293630
  • 财政年份:
    2005
  • 资助金额:
    $ 15万
  • 项目类别:
Software for Fitting Non-Gaussian Random Effects Models
用于拟合非高斯随机效应模型的软件
  • 批准号:
    7003818
  • 财政年份:
    2004
  • 资助金额:
    $ 15万
  • 项目类别:

相似海外基金

How Does Particle Material Properties Insoluble and Partially Soluble Affect Sensory Perception Of Fat based Products
不溶性和部分可溶的颗粒材料特性如何影响脂肪基产品的感官知觉
  • 批准号:
    BB/Z514391/1
  • 财政年份:
    2024
  • 资助金额:
    $ 15万
  • 项目类别:
    Training Grant
BRC-BIO: Establishing Astrangia poculata as a study system to understand how multi-partner symbiotic interactions affect pathogen response in cnidarians
BRC-BIO:建立 Astrangia poculata 作为研究系统,以了解多伙伴共生相互作用如何影响刺胞动物的病原体反应
  • 批准号:
    2312555
  • 财政年份:
    2024
  • 资助金额:
    $ 15万
  • 项目类别:
    Standard Grant
RII Track-4:NSF: From the Ground Up to the Air Above Coastal Dunes: How Groundwater and Evaporation Affect the Mechanism of Wind Erosion
RII Track-4:NSF:从地面到沿海沙丘上方的空气:地下水和蒸发如何影响风蚀机制
  • 批准号:
    2327346
  • 财政年份:
    2024
  • 资助金额:
    $ 15万
  • 项目类别:
    Standard Grant
Graduating in Austerity: Do Welfare Cuts Affect the Career Path of University Students?
紧缩毕业:福利削减会影响大学生的职业道路吗?
  • 批准号:
    ES/Z502595/1
  • 财政年份:
    2024
  • 资助金额:
    $ 15万
  • 项目类别:
    Fellowship
感性個人差指標 Affect-X の構築とビスポークAIサービスの基盤確立
建立个人敏感度指数 Affect-X 并为定制人工智能服务奠定基础
  • 批准号:
    23K24936
  • 财政年份:
    2024
  • 资助金额:
    $ 15万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Insecure lives and the policy disconnect: How multiple insecurities affect Levelling Up and what joined-up policy can do to help
不安全的生活和政策脱节:多种不安全因素如何影响升级以及联合政策可以提供哪些帮助
  • 批准号:
    ES/Z000149/1
  • 财政年份:
    2024
  • 资助金额:
    $ 15万
  • 项目类别:
    Research Grant
How does metal binding affect the function of proteins targeted by a devastating pathogen of cereal crops?
金属结合如何影响谷类作物毁灭性病原体靶向的蛋白质的功能?
  • 批准号:
    2901648
  • 财政年份:
    2024
  • 资助金额:
    $ 15万
  • 项目类别:
    Studentship
Investigating how double-negative T cells affect anti-leukemic and GvHD-inducing activities of conventional T cells
研究双阴性 T 细胞如何影响传统 T 细胞的抗白血病和 GvHD 诱导活性
  • 批准号:
    488039
  • 财政年份:
    2023
  • 资助金额:
    $ 15万
  • 项目类别:
    Operating Grants
New Tendencies of French Film Theory: Representation, Body, Affect
法国电影理论新动向:再现、身体、情感
  • 批准号:
    23K00129
  • 财政年份:
    2023
  • 资助金额:
    $ 15万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
The Protruding Void: Mystical Affect in Samuel Beckett's Prose
突出的虚空:塞缪尔·贝克特散文中的神秘影响
  • 批准号:
    2883985
  • 财政年份:
    2023
  • 资助金额:
    $ 15万
  • 项目类别:
    Studentship
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了