Mentoring Translational Research in HIV

描述（由申请人提供）：虽然继续取得重大进展，但不太可能很快开发出安全有效的艾滋病毒治疗或疫苗。这些目标的成功将取决于未来的艾滋病毒研究人员，其中许多人可能在未来五到十年内接受培训。该K24提案的目标是为申请人提供咨询支持，以指导学员进行最先进的转化和以患者为导向的艾滋病毒研究，并扩大他在UCSD广泛的培训计划中的参与。该应用程序是建立在资助，积极和正在进行的研究项目，其中学员是主要领导者，并在研究设计，执行，分析，结果解释和出版的各个方面进行培训。所提出的研究提供了深入指导的机会，以及对艾滋病毒发病机制中重要和开放的科学问题的调查。这些目标将在以下三个目标中实现，其中包括多项临床研究和六名现有学员。具体目标1：通过研究生殖道（1A）、肠道相关淋巴组织（1B）和血液中的中和抗体反应（1C），确定原发性HIV感染期间的病毒学和免疫学动力学。具体目标2：在资源有限的情况下验证用于诊断目的的汇集方法，以检测：抗逆转录病毒治疗的病毒学失败（2A）和艾滋病毒感染情况下的亚急性疟疾感染（2B）。具体目标3：使用分子流行病学方法来表征圣地亚哥和蒂华纳之间的HIV-1传播网络。总的来说，这项建议将使职业生涯中期的申请人继续和扩大他的艾滋病毒研究和指导活动。 公共卫生相关性：未来艾滋病毒研究的成功将取决于今天对新研究人员的培训。本K24提案的目标是通过减少申请人在行政和临床职责上花费的时间，让申请人继续并扩大其指导活动。如果这项提议成功，他将能够将至少90%的时间用于艾滋病毒研究，并指导初级教师，传染病研究员以及翻译艾滋病毒研究的研究生和博士后学生。

DESCRIPTION (provided by applicant): While significant progress continues to be made, it is not likely that a safe and effective cure or vaccine for HIV will be developed soon. The success of these goals will depend on future HIV researchers, many of whom are likely to be trained in the next five to ten years. The goal of this K24 proposal is to provide the applicant with sufficiet support to mentor trainees in state-of-the-art translational and patient oriented HIV research and to expand his involvement in UCSD's wide array of training programs. This application is built upon funded, active and ongoing research projects, where the mentee is the primary leader and is trained in every aspect of study design, execution, analyses, results interpretation and publication. The presented studies provide opportunities for in-depth mentoring as well as investigation into important and open scientific questions in HIV pathogenesis. These goals will be met in the following three aims, which incorporate multiple clinical studies and six current mentees. SPECIFIC AIM 1: To determine virologic and immunologic dynamics during primary HIV infection by investigating: the genital tract (1A), gut associated lymphoid tissue (1B), and the neutralizing antibody response in the blood (1C). SPECIFIC AIM 2: To validate pooling methods for diagnostic purposes in resource limited settings to detect: virologic failure of antiretroviral therapy (2A) and sub-acute malaria infection in the setting of HIV infection (2B). SPECIFIC AIM 3: To use molecular epidemiologic methods to characterize HIV-1 transmission networks between San Diego and Tijuana. Taken together, this proposal will allow the mid-career applicant to continue and expand his HIV research and mentoring activities. PUBLIC HEALTH RELEVANCE: The success of future HIV research will depend on the training of new researchers today. The goal of this K24 proposal is to allow the applicant to continue and expand his mentoring activities by reducing the amount of his time spent on administrative and clinical responsibilities. If this proposal is successful, he will be able to deote at least 90% of his time to HIV research and mentoring of junior faculty, Infectious Disease fellows, and graduate and post-doctoral students in translational HIV research.