Global Health Research and Training in HIV and Tuberculosis

描述（由申请人提供）：我的长期职业目标是为美国和国际医生科学家开发一个全球健康研究培训项目，重点是艾滋病毒和结核病。这项K24提案的目标是通过主要在海地和坦桑尼亚进行研究来培养内科科学家和优秀的博士预科学生，并在海地开展一项关于艾滋病毒引起的慢性炎症的新研究项目。美国受训人员将在海地和坦桑尼亚的国际研究基地度过大约60%的时间，那里有威尔康奈尔大学的现场教师、先进的电信设备和优秀的研究培训环境。内科科学家可以在威尔康奈尔医学院攻读临床流行病学和卫生服务研究硕士学位。该研究战略包括由K24艾滋病诱导慢性炎症奖（AIM 1）支持的在海地的一个新研究项目、目前在海地资助的项目（AIMS 2 - 5），以及目前在坦桑尼亚Mwanza一个新研究地点资助的一个项目（AIM 6）。共同的主题是，所有项目都以艾滋病和结核病患者为导向的研究为重点，并将作为研究学员的培训工具。项目包括以下内容：延迟抗逆转录病毒治疗导致的慢性炎症：生物标志物和后遗症2。前列腺素E2在HIV感染妇女宫颈癌中的作用结核病诊断和监测治疗的生物标志物艾滋病毒疫苗和抗逆转录病毒治疗临床试验耐多药结核病监测和控制女性泌尿生殖系统血吸虫病和艾滋病毒的相互作用其中五个项目涉及对海地队列的长期研究，第六个项目涉及对坦桑尼亚队列的长期研究。所有的研究都有临床和实验室方面，为受训者提供广泛的经验。受训者通过独立的项目进行学习，并有机会与从事其他研究的同事互动。

DESCRIPTION (provided by applicant): My long-term career goal is to develop a global health research-training program for United States and international physician-scientists with a focus on HIV and tuberculosis. The goals of this K24 proposal are to train physician scientists and outstanding pre-doctoral students through the conduct of research primarily in Haiti, and also in Tanzania and to conduct a new research project on HIV induced chronic inflammation in Haiti. United States trainees will spend ~60% of their time at international research sites in Haiti and Tanzania, which have on-site Weill Cornell faculty, advanced telecommunications, and outstanding environments for research training. Physician-scientists may pursue a Master of Science (MS) in Clinical Epidemiology and Health Services Research at Weill Cornell Medical College. The research strategy includes a new research project in Haiti to be supported by the K24 award on HIV induced chronic inflammation (AIM 1), currently funded projects in Haiti (AIMS 2 - 5), and a currently funded project at a new research site in Mwanza, Tanzania (AIM 6). The common theme is that all the projects have patient-oriented research on AIDS and TB as the focus and will serve as training vehicles for research trainees. The projects include the following: 1. Chronic inflammation as a consequence of delayed ART: biomarkers and sequelae 2. Cervical cancer in HIV infected women: role of prostaglandin E2 3. Tuberculosis biomarkers for diagnosis and for monitoring therapy 4. HIV vaccine and ART clinical trials 5. Multidrug resistant tuberculosis surveillance and control 6. Female urogenital schistosomiasis and HIV interactions Five of the projects involve long-term study of cohorts in Haiti, and the sixth a cohot in Tanzania. There are both clinical and laboratory aspects to all studies which offer trainees broad experience. Trainees learn through the conduct of an independent project and the opportunity to interact with colleagues working on studies other than their own. PUBLIC HEALTH RELEVANCE: The K24 proposal will support Dr Daniel Fitzgerald to train physician scientists and outstanding pre-doctoral students through the conduct of HIV and tuberculosis research primarily in Haiti, and also in Tanzania and to conduct a new project on HIV induced chronic inflammation in Haiti. Physician-scientist trainees may also pursue a Master of Science (MS) in Clinical Epidemiology and Health Services Research at Weill Cornell Medical College.