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Rate of Weight Gain, Linear Growth, and Development During Childhood

儿童时期的体重增加率、线性生长和发育

基本信息

批准号：
8209032
负责人：
Joyce Lee
金额：
$ 8.38万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-12-27 至 2012-11-30
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): Increases in weight gain among US children related to the childhood obesity epidemic may result in alteration of normal patterns of childhood linear growth and development. Few studies have evaluated the impact of weight gain on linear growth patterns or the relationship of linear growth with pubertal timing for a population- based sample of US children followed longitudinally. Using data from the National Institute of Child Health and Human Development Study of Early Child Care and Youth Development, a comprehensive study which collected longitudinal growth and puberty measurements on a population-based cohort of children of diverse socioeconomic status from birth to age 15 years, this proposal provides an unprecedented opportunity to evaluate the following specific aims: Aim 1: To evaluate the association of early childhood (ages 2 -7 years) BMI increases with height gain during early childhood (ages 2-7 years) and how this association varies by gender. Aim 2: To evaluate the association of early childhood (ages 2 -7 years) BMI increases with the timing and magnitude of the adolescent growth spurt (peak height velocity) and height gain during adolescence (ages 9 - 15 years) separately for boys and girls. Aim 3: To evaluate the relationship between timing of height takeoff and peak height velocity with puberty separately for boys and girls. Aim 4: To assess the % of children in the population classified as early, average, and late maturers, based on their individual height velocity curves, and to compare BMI z-scores, increases in BMI during early childhood, and proportion overweight and obese, between early, average, and late maturers for boys and for girls. Results of the proposed study will offer an improved understanding of the relationship between weight gain in early childhood and alterations in patterns of linear growth, as well as the relationship between linear growth patterns and pubertal timing. This information is critical for ensuring accurate interpretation of childhood growth patterns in clinical practice, as well as for offering important insights into mechanisms of childhood linear growth and development. PUBLIC HEALTH RELEVANCE: The epidemic of childhood obesity among US children may result in alterations of normal patterns of childhood linear growth and development. Studies to evaluate the impact of weight gain and obesity on childhood linear growth and development will have practical implications regarding interpretation of the etiology of children's growth patterns, as well as theoretic implications regarding the potential mechanism of excess adiposity in driving growth and development.

描述（由申请人提供）：与儿童肥胖流行相关的美国儿童体重增加可能导致儿童正常线性生长和发育模式的改变。很少有研究评估体重增加对线性生长模式的影响，或者对以美国儿童为样本的纵向跟踪的线性生长与青春期时间的关系。利用国家儿童健康和人类发展研究所早期儿童保育和青少年发展研究的数据，这是一项综合研究，收集了从出生到15岁的不同社会经济地位的儿童的纵向生长和青春期的测量数据，该建议提供了一个前所未有的机会来评估以下具体目标：评估儿童早期（2-7岁）体重指数随儿童早期（2-7岁）身高增加而增加的关系，以及这种关系如何因性别而异。目的2：分别评估儿童早期（2 -7岁）BMI增加与青春期生长突增（高峰身高速度）和青春期（9 - 15岁）身高增加的时间和幅度之间的关系。目的3：分别评价男孩和女孩身高起飞时间和最高身高速度与青春期的关系。目的4：评估根据个体身高速度曲线划分为早熟、平均和晚熟的儿童的百分比，并比较早熟、平均和晚熟的男孩和女孩的BMI z分数、儿童早期BMI的增加以及超重和肥胖的比例。这项研究的结果将有助于更好地理解儿童早期体重增加与线性生长模式改变之间的关系，以及线性生长模式与青春期时间之间的关系。这些信息对于确保在临床实践中准确解释儿童生长模式至关重要，同时也为儿童线性生长和发育的机制提供了重要的见解。