Fluorescent Organic Nanoparticles that are Monovalent, Ultra-Stable, and Biocompa
单价、超稳定和 Biocompa 荧光有机纳米颗粒
基本信息
- 批准号:8210980
- 负责人:
- 金额:$ 27.06万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-01-01 至 2013-12-31
- 项目状态:已结题
- 来源:
- 关键词:AffinityAlkenesAminesArchitectureBiocompatibleBiological ProcessBiologyCharacteristicsChemicalsChemistryDefectDendrimersDiagnosticDyesEncapsulatedExhibitsFluoresceinFluorescein-5-isothiocyanateFluorescent DyesGlycolsGoalsLinkMedicalMedicineMembraneMembrane ProteinsMolecularMolecular BiologyOligonucleotidesOne-Step dentin bonding systemPerformancePhotobleachingPolymersProcessPropertyProtocols documentationReactionSchemeSiliconSiteSolubilityStagingStructureSurfaceTailToxic effectWateraqueousbasechromophorecrosslinkdesignfluorophorefunctional groupglycidolirradiationnanoparticleorganic baseparticlepolyglycerolpreventpropargyl alcoholpublic health relevancesurface coatingtoxic metal
项目摘要
DESCRIPTION (provided by applicant): Fluorescent dyes and nanoparticles are widely used in chemistry, biology, and medicine but suffer from poor photostability or toxicity (nanoparticles). The goal of this proposal is to create ultra-stable, monovalent, organic nanoparticles or organic coated metallic/silicon nanoparticles (< 6 nm size) using recently discovered chemistry that allows polyglycerol dendrimers and hyperbranched polymers to be tightly cross-linked around a core structure. The polyglycerol surfaces will be allylated and cross-linked using the ring-closing metathesis (RCM) reaction, followed by surface dihydroxylation to create a water-soluble particle. This chemistry is colloquially referred to as "multi-layer shrink-wrapping." The goal of the shrink-wrapping is to chemically isolate the fluorophore or preexisting nanoparticle and thus: (1) prevent dye aggregation, which often diminishes its performance, (2) prevent its undesired association with membranes and other biomolecules, and, most importantly, (3) reduce or eliminate photobleaching, and (4) stabilize existing nanoparticles with a dense, biocompatible sheath. We propose that through extreme isolation of the fluorophore or nanoparticle it may function indefinitely, thereby enabling a range of applications not previously possible. The fluorescent nanoparticles, which are designed to be fully biocompatible, can exhibit a range of excitation and emission wavelengths.
PUBLIC HEALTH RELEVANCE: Fluorescent dyes and nanoparticles are widely used in medical diagnostics and for understanding chemical and biological processes at the molecular and cellular level. However, the dyes degrade rapidly upon irradiation and many nanoparticles contain toxic metals or are inherently toxic because of their surface coating. We propose a new strategy for preparing organic-based, ultra-stable and biocompatible fluorescent nanoparticles.
描述(申请人提供):荧光染料和纳米颗粒广泛应用于化学、生物和医学,但光稳定性差或毒性(纳米颗粒)。该提案的目标是利用最近发现的化学方法,使聚甘油树状大分子和超支化聚合物在核心结构周围紧密交联,创造出超稳定的、单价的有机纳米颗粒或有机涂层金属/硅纳米颗粒(< 6纳米尺寸)。聚甘油表面将通过闭合环复分解反应(RCM)进行烯丙化和交联,然后进行表面二羟基化以产生水溶性颗粒。这种化学反应通常被称为“多层收缩包装”。收缩包裹的目的是化学分离荧光团或预先存在的纳米颗粒,从而:(1)防止染料聚集,这通常会降低其性能;(2)防止其与膜和其他生物分子的不希望的结合,最重要的是,(3)减少或消除光漂白;(4)用致密的生物相容性护套稳定现有的纳米颗粒。我们提出,通过对荧光团或纳米颗粒的极端隔离,它可能无限期地发挥作用,从而实现一系列以前不可能实现的应用。荧光纳米粒子被设计成完全生物相容性,可以表现出一系列的激发和发射波长。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Steven C. Zimmerman其他文献
Rational Design of Potent Dimeric Ligands as Potential Theraputic Agents for Myotonic Dystrophy Type I (DM1)
- DOI:
10.1016/j.bpj.2011.11.2647 - 发表时间:
2012-01-31 - 期刊:
- 影响因子:
- 作者:
Amin H. Jahromi;Steven C. Zimmerman - 通讯作者:
Steven C. Zimmerman
Capturing students' identification of the relevance of organic chemistry in writing
在写作中捕捉学生对有机化学相关性的认识
- DOI:
- 发表时间:
2023 - 期刊:
- 影响因子:3
- 作者:
Safron L. Milne;S. Finkenstaedt;Nicholas F. Garza;Steven C. Zimmerman;G. Shultz - 通讯作者:
G. Shultz
Hocheffektive, über Wasserstoffbrücken bindende Rezeptoren für Guanidinderivate
Hocheffektive, über Wasserstoffbrücken bindende Rezeptoren für guanidinderivate
- DOI:
- 发表时间:
1995 - 期刊:
- 影响因子:0
- 作者:
Thomas W. Bell;Zheng Hou;Steven C. Zimmerman;P. A. Thiessen - 通讯作者:
P. A. Thiessen
A very versatile nanocapsule
一种非常通用的纳米胶囊
- DOI:
10.1038/nnano.2007.90 - 发表时间:
2007-04-01 - 期刊:
- 影响因子:34.900
- 作者:
Darrell W. Kuykendall;Steven C. Zimmerman - 通讯作者:
Steven C. Zimmerman
Steven C. Zimmerman的其他文献
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{{ truncateString('Steven C. Zimmerman', 18)}}的其他基金
Small Molecule Approaches to Targeting the DNA and RNA in Myotonic Dystrophy
强直性肌营养不良中靶向 DNA 和 RNA 的小分子方法
- 批准号:
9239005 - 财政年份:2017
- 资助金额:
$ 27.06万 - 项目类别:
Fluorescent Organic Nanoparticles that are Monovalent, Ultra-Stable, and Biocompa
单价、超稳定和 Biocompa 荧光有机纳米颗粒
- 批准号:
8412779 - 财政年份:2010
- 资助金额:
$ 27.06万 - 项目类别:
Fluorescent Organic Nanoparticles that are Monovalent, Ultra-Stable, and Biocompa
单价、超稳定和 Biocompa 荧光有机纳米颗粒
- 批准号:
8011169 - 财政年份:2010
- 资助金额:
$ 27.06万 - 项目类别:
Fluorescent Organic Nanoparticles that are Monovalent, Ultra-Stable, and Biocompa
单价、超稳定和 Biocompa 荧光有机纳米颗粒
- 批准号:
7784089 - 财政年份:2010
- 资助金额:
$ 27.06万 - 项目类别:
TETHERED NUCLEOBASES FOR ENHANCED DNA RECOGNITION
用于增强 DNA 识别的束缚核碱基
- 批准号:
6623068 - 财政年份:2002
- 资助金额:
$ 27.06万 - 项目类别:
TETHERED NUCLEOBASES FOR ENHANCED DNA RECOGNITION
用于增强 DNA 识别的束缚核碱基
- 批准号:
6460920 - 财政年份:2002
- 资助金额:
$ 27.06万 - 项目类别:
TETHERED NUCLEOBASES FOR ENHANCED DNA RECOGNITION
用于增强 DNA 识别的束缚核碱基
- 批准号:
6931507 - 财政年份:2002
- 资助金额:
$ 27.06万 - 项目类别:
TETHERED NUCLEOBASES FOR ENHANCED DNA RECOGNITION
用于增强 DNA 识别的束缚核碱基
- 批准号:
6781884 - 财政年份:2002
- 资助金额:
$ 27.06万 - 项目类别:
SYNTHETIC ANTIBODIES BY MONOMOLECULAR POLYMER IMPRINTING
通过单分子聚合物印迹合成抗体
- 批准号:
6283494 - 财政年份:2001
- 资助金额:
$ 27.06万 - 项目类别:
SYNTHETIC ANTIBODIES BY MONOMOLECULAR POLYMER IMPRINTING
通过单分子聚合物印迹合成抗体
- 批准号:
6520204 - 财政年份:2001
- 资助金额:
$ 27.06万 - 项目类别:
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