JEOL JEM-1400 Transmission Electron Microscope

描述（由申请人提供）：本提案要求提供资金，用于购买JEOL JEM-1400透射电子显微镜（TEM），以取代我们位于亚利桑那州健康科学核心成像设施的老化的21岁飞利浦CM 12 S。现有的CM-12 S的维修停机时间越来越长，更换零件越来越难获得（FEI将只支持现有的CM-12 S 30-36个月-见附件）。JEOL JEM-1400将成为亚利桑那大学基础和临床研究人员可用的主要TEM。用新的TEM代替老化的显微镜将确保亚利桑那大学的研究人员在可预见的未来可以使用这项技术。JEOL JEM-1400是满足我们研究人员需求的基本120 kV TEM。它易于使用，有几个数字成像选项，可以从远程位置操作。该仪器将支持8个NIH资助的主要用户，他们需要TEM进行研究。使用JEOL JEM-1400收集的细胞和组织超微结构数据将用于增加我们对结肠癌和食管癌、心脏和肌肉功能和功能障碍、器官发育过程中有毒物质的影响、心血管功能和免疫功能的理解。

DESCRIPTION (provided by applicant): Funds are requested in this proposal to purchase a JEOL JEM-1400 transmission electron microscope (TEM) to replace our aging, 21 year old Philips CM12S located in the Arizona Health Sciences Core Imaging Facility. The existing CM12S has increasing downtime for repairs with replacement parts becoming more difficult to obtain (FEI will only support the existing CM-12S for 30-36 months - see attached letter). The JEOL JEM-1400 will be the primary TEM available to basic and clinical researchers at the University of Arizona. Replacement of the aging microscope with a new TEM will insure that this technology is available to researchers at the University of Arizona for the foreseeable future. The JEOL JEM-1400 is a basic 120 kV TEM that meets the needs of our researchers. It is easy to use, has several digital imaging options and can be operated from remote locations. The instrument will support 8 NIH-funded major users who require the TEM for their research. Cellular and tissue ultra structural data collected using the JEOL JEM-1400 will be used to increase our understanding of colon and esophageal cancer, heart and muscle function and dysfunction, effects of toxicants during organ development, cardiovascular function, and immune function.