Assessing Deworming Programs Targeted to Adolescent and Adult Women

育龄妇女，包括青春期女孩、怀孕第二或第三个三个月的孕妇和哺乳期妇女，是土壤传播蠕虫(主要是鞭虫和钩虫感染)致病的高危群体。在其他全球、区域和国家组织中，世卫组织建议在钩虫感染率超过20%的流行地区针对这一群体进行大规模驱虫。我们提出的研究将提供经验证据，指导针对这一高危群体的大规模驱虫计划的卫生政策和计划实施。确定了四个目标：1)对怀孕前三个月不慎接触驱虫的情况进行系统审查；2)评估学龄少女回答有关怀孕的问题的接受程度(排除在以学校为基础的驱虫方案期间的头三个月期间驱虫的可能性)；3)确定妇女在怀孕阶段首先到产前保健诊所就诊；以及4)确定分娩后立即在医院对妇女进行驱虫对母亲和婴儿的健康影响。这项研究的结果将有助于确保针对育龄妇女的驱虫计划具有成本效益和效率，并最终减轻这一脆弱人群中蠕虫感染的疾病负担。

Women of reproductive age, including adolescent girls, pregnant women in their second or third trimester, and lactating women constitute a high-risk group for morbidity attributable to the soil-transmitted helminths, primarily Trichuris and hookworm infections. WHO, among other global, regional and national organizations, recommends mass deworming targeted to this group in endemic areas where the prevalence of hookworm infection exceeds 20%. The research we propose will provide empirical evidence on which to guide health policy and program implementation for large-scale deworming programs targeting this at-risk group. Four objectives are identified: 1) to conduct a systematic review of inadvertent exposure to deworming in the first trimester of pregnancy; 2) to assess the receptiveness of adolescent girls of school- age to answer questions on pregnancy (to rule out deworming during the first trimester during school-based deworming programs); 3) to determine the stage of pregnancy at which women will first attend an antenatal care clinic; and 4) to determine the health impact, to mothers and babies, of deworming administered to women in-hospital, immediately after delivery. The results of this research will contribute to ensuring cost- effective and efficient deworming programs targeted to women of reproductive age and, ultimately, to reducing the disease burden of helminth infection in this vulnerable population.