Assessing Deworming Programs Targeted to Adolescent and Adult Women

育龄妇女，包括少女、妊娠中期或晚期的孕妇和哺乳期妇女是因土壤传播的蠕虫，主要是毛线虫和钩虫感染而发病的高危群体。世卫组织与其他全球、区域和国家组织一道，建议在钩虫感染流行率超过20%的流行地区针对这一群体进行大规模驱虫。我们提出的研究将为指导针对这一高危群体的大规模驱虫计划的卫生政策和计划实施提供经验证据。确定了四个目标：1)对怀孕前三个月无意中接触驱虫剂进行系统审查；2)评估学龄少女回答有关怀孕问题的接受程度（在学校驱虫计划中排除在妊娠头三个月进行驱虫）；3)确定妇女在怀孕的哪个阶段将首先到产前保健诊所就诊；4)确定在分娩后立即对住院妇女进行驱虫对母亲和婴儿健康的影响。这项研究的结果将有助于确保针对育龄妇女的成本效益和高效的驱虫计划，并最终减少这一脆弱人群中蠕虫感染的疾病负担。

Women of reproductive age, including adolescent girls, pregnant women in their second or third trimester, and lactating women constitute a high-risk group for morbidity attributable to the soil-transmitted helminths, primarily Trichuris and hookworm infections. WHO, among other global, regional and national organizations, recommends mass deworming targeted to this group in endemic areas where the prevalence of hookworm infection exceeds 20%. The research we propose will provide empirical evidence on which to guide health policy and program implementation for large-scale deworming programs targeting this at-risk group. Four objectives are identified: 1) to conduct a systematic review of inadvertent exposure to deworming in the first trimester of pregnancy; 2) to assess the receptiveness of adolescent girls of school- age to answer questions on pregnancy (to rule out deworming during the first trimester during school-based deworming programs); 3) to determine the stage of pregnancy at which women will first attend an antenatal care clinic; and 4) to determine the health impact, to mothers and babies, of deworming administered to women in-hospital, immediately after delivery. The results of this research will contribute to ensuring cost- effective and efficient deworming programs targeted to women of reproductive age and, ultimately, to reducing the disease burden of helminth infection in this vulnerable population.