Assessing Deworming Programs Targeted to Adolescent and Adult Women

育龄妇女，包括少女、妊娠中期或晚期的孕妇和哺乳期妇女，是土壤传播的蠕虫，主要是鞭虫和钩虫感染的高风险群体。除其他全球、区域和国家组织外，世卫组织建议在钩虫感染流行率超过20%的流行地区针对这一群体进行大规模驱虫。我们提出的研究将提供经验证据，以指导卫生政策和计划实施的大规模驱虫计划，针对这一风险群体。确定了四个目标：1）对怀孕前三个月无意中接触驱虫剂的情况进行系统审查; 2）评估学龄少女回答怀孕问题的接受程度。（在学校驱虫方案中，排除在头三个月驱虫）; 3）确定妇女将首先到产前保健诊所就诊的怀孕阶段;以及4）确定在分娩后立即对住院妇女进行驱虫对母亲和婴儿的健康影响。这项研究的结果将有助于确保针对育龄妇女的具有成本效益和效率的驱虫方案，并最终减少这一脆弱人群蠕虫感染的疾病负担。

Women of reproductive age, including adolescent girls, pregnant women in their second or third trimester, and lactating women constitute a high-risk group for morbidity attributable to the soil-transmitted helminths, primarily Trichuris and hookworm infections. WHO, among other global, regional and national organizations, recommends mass deworming targeted to this group in endemic areas where the prevalence of hookworm infection exceeds 20%. The research we propose will provide empirical evidence on which to guide health policy and program implementation for large-scale deworming programs targeting this at-risk group. Four objectives are identified: 1) to conduct a systematic review of inadvertent exposure to deworming in the first trimester of pregnancy; 2) to assess the receptiveness of adolescent girls of school- age to answer questions on pregnancy (to rule out deworming during the first trimester during school-based deworming programs); 3) to determine the stage of pregnancy at which women will first attend an antenatal care clinic; and 4) to determine the health impact, to mothers and babies, of deworming administered to women in-hospital, immediately after delivery. The results of this research will contribute to ensuring cost- effective and efficient deworming programs targeted to women of reproductive age and, ultimately, to reducing the disease burden of helminth infection in this vulnerable population.