Improving Childhood Growth and Development in Resource-Poor LMICs with Deworming

学龄前儿童是土壤传播的疟疾发病的三个高危群体之一， 蠕虫感染（STH）。在这个年龄，最重要的STH感染是蛔虫和鞭虫 感染.世卫组织建议对12个月大的学龄前儿童进行驱虫，但没有 关于驱虫暴露的经验证据（根据给药时的年龄和 （3）对健康的影响最大。因此，本研究项目建议遵循 一组已知有不同驱虫暴露组蛋白的学龄前儿童 年龄在12到24个月之间。通过对这些儿童进行长达5岁的跟踪， 将衡量效益并确定最佳驱虫战略。预计这些健康 福利将延伸到儿童后期及以后。研究结果也将用于指导驱虫 全球性病流行地区卫生政策和战略。 相关性（参见说明）： 在12至24个月之间存在一个重要的机会窗口， 干预措施在短期和长期健康方面都发挥着至关重要的作用。重要的是要衡量这种健康 影响，不仅因为它填补了研究空白，而且因为它是对规划有用反馈 经理和其他合作伙伴。在跟踪五岁以下儿童时，这项队列研究将提供关键信息 Rmf^irica！ftvidenr.fi ri.sk关于不同dewnrmina strataifis对健康的影响，

Preschool-age children are one of the three high risk groups for morbidity attributable to soil-transmitted helminth infections (STH). At this age, the STH infections of most importance are Ascaris and Trichuris infections. WHO recommends deworming of preschool-age children as of 12 months of age, but there is no empirical evidence on what deworming exposure (in terms of age at administration adn frequency of administration) has the most beneficial impact on health. This research project therefore proposes to follow a cohort of preschool-age children who are known to have had different deworming exposure histones between 12 and 24 months of age. By following these children up to five years of age, cumulative health benefits will be measured and the optimal deworming strategy identified. It is expected that these health benefits will extend into later childhood and beyond. Research results will also be used to inform deworming health policy and strategies in STH-endemic regions globally. RELEVANCE (See instructions): An important window of opportunity exists between 12 and 24 months of age when health and nutrition interventions play a vital role in both short and long term health. It is important to measure this health impact, not only because it fills a research gap, but also because it is useful feedback for program managers, and other partners. In following children up to five years of age, this cohort study will provide key Rmf^irica! ftvidenr.fi on the health impact of different dewnrmina strateaifis tarafited to this high ri.sk ana