Longitudinal measurement of the changing sleep need in adolescence

青春期睡眠需求变化的纵向测量

• 批准号: 8577026
• 负责人: IRWIN FEINBERG
• 金额: $ 51.17万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8577026
• 关键词: 14 year old; 16 year old; 17 year old; Address; Adolescence; Adolescent; Affect; Age; Awareness; Beds; Biological; Brain; Centers for Disease Control and Prevention (U.S.); Child; Circadian Rhythms; Cognitive; Complex; Data; Development; Dose; Drowsiness; Electroencephalogram; Electroencephalography; Evaluation; Excessive Daytime Sleepiness; Foundations; Guidelines; Habits; Health behavior; Hour; Hygiene; Individual Differences; Knowledge; Laboratories; Longitudinal Studies; Measurement; Measures; Mental Health; Moods; Participant; Performance; Phase; Physiological; Public Health; Recommendation; Schedule; Schools; Sex Characteristics; Sleep; Teenagers; Testing; Time; Variant; actigraphy; age related; alertness; base; design; falls; longitudinal design; non rapid eye movement; novel; physical conditioning; public health relevance; research study; response; sleep regulation; vigilance

DESCRIPTION (provided by applicant): The negative effects of insufficient sleep in children and adolescents are well documented. Sleep loss and daytime sleepiness impact school performance, health, and behavior. Despite the increasing awareness of the public health impact, major gaps remain in our understanding of adolescent sleep and daytime sleepiness. Currently the Centers for Disease Control and National Sleep Foundation recommend 8.5-9.5 hours of sleep for 10-17 year olds. These guidelines are based on data showing that sleep propensity is stable or even increases across adolescence. However, sleep propensity studies do not address the effects of sleep restriction on daytime functioning. Most studies that have attempted to establish the effects of sleep duration on daytime performance in adolescents have correlated poor performance to poor sleep habits rather than experimentally manipulating prior sleep duration. Moreover, no study has evaluated how the effects of sleep restriction change with age across adolescence. The longitudinal study proposed here will use a within-subject dose-response design to examine the maturational trajectory of sleep need as determined by the relation of experimentally varied sleep duration to daytime functioning and sleepiness. Eighty participants will enter the study between 10 and 14 years of age and be studied for 4 years. Thus, the longitudinal study will cover ages 10 to 18 years. Daytime performance and daytime sleepiness will be measured on separate occasions following four nights with time in bed restricted to 7, 8.5, or 10 hours. Annually all participants will complete the 3 different slee duration conditions within a 3 month period. Daytime performance as well as daytime sleepiness will be measured in laboratory testing sessions. Performance on a simple vigilance task and a more complex cognitive task will be evaluated. Daytime sleepiness will be measured objectively using the same multiple sleep latency test that forms the basis of the Centers for Disease Control adolescent sleep guidelines. Daytime sleepiness will also be measured objectively with theta and alpha electroencephalogram activity, and subjects will subjectively rate their sleepiness and mood. Our previous longitudinal study established that slow wave EEG activity during non-rapid eye movement sleep declines steeply between ages 12 and 16 years of age. The proposed study will determine if the age trajectories of the relations between sleep duration and performance or sleepiness are associated with the adolescent brain maturation reflected in the slow wave EEG decline. Age related circadian changes, determined by actigraphy during a week when subjects keep their habitual sleep scheduled, will be controlled for statistically in the evaluation of maturational changes in the performance vs. sleep duration dose-response curve. The results of this proposed project will provide the first longitudinal dose-response data measuring changes in sleep need across adolescence allowing more informed recommendations for adolescent sleep hygiene.

描述（由申请人提供）：记录在儿童和青少年中睡眠不足的负面影响。睡眠损失和白天嗜睡会影响学校的表现，健康和行为。尽管对公共卫生影响的认识越来越高，但我们对青少年睡眠和白天嗜睡的理解仍然存在重大差距。目前，疾病控制和国家睡眠基金中心建议10-17岁的年轻人为8.5-9.5小时的睡眠。这些指南基于数据，表明睡眠倾向是稳定的，甚至在整个青春期都会增加。但是，睡眠倾向研究并未解决睡眠限制对白天功能的影响。大多数试图确定睡眠持续时间对青少年白天表现影响的研究与睡眠习惯不佳相关，而不是通过实验操纵先前的睡眠持续时间。此外，尚无研究评估睡眠限制的影响如何随着青春期的年龄而变化。此处提出的纵向研究将使用受试者内剂量反应设计来检查睡眠需求的成熟轨迹，这取决于实验性睡眠持续时间与白天的功能和嗜睡的关系。 80名参与者将进入10至14岁之间的研究，并研究4年。因此，纵向研究将涵盖10至18岁的年龄。在四个晚上，床上的时间仅限于7、8.5或10小时，将在不同的场合分别测量白天的表现和白天的嗜睡。每年所有参与者将在3个月内完成3种不同的袖子持续时间。白天的表现以及白天的嗜睡将在实验室测试课程中衡量。将评估简单警惕任务和更复杂的认知任务的表现。白天嗜睡将使用相同的多重睡眠潜伏期测试客观地测量，该测试构成了疾病控制青少年睡眠准则的基础。白天的嗜睡还将通过Theta和Alpha脑电图活动进行客观测量，受试者将主观评估其嗜睡和情绪。我们先前的纵向研究表明，在非比型眼运动睡眠期间的慢波脑电图在12至16岁之间急剧下降。拟议的研究将确定睡眠持续时间与性能或嗜睡之间关系的年龄轨迹是否与慢波脑电图下降反映的青少年脑成熟有关。与年龄相关的昼夜节律变化，在受试者安排习惯性睡眠安排的一周内由Actraphy确定，在评估性能与睡眠持续时间剂量剂量响应曲线的评估时，将受到统计的控制。该提议的项目的结果将提供第一个纵向剂量反应数据，以测量整个青春期睡眠需求的变化，从而为青少年睡眠卫生提供了更明智的建议。