Longitudinal measurements of sleep EEG in adolescence

青春期睡眠脑电图的纵向测量

• 批准号: 6472359
• 负责人: IRWIN FEINBERG
• 金额: $ 44.33万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-17 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6472359
• 关键词: adolescence (12-20); age difference; behavior test; behavioral /social science research tag; brain electrical activity; clinical research; computer data analysis; developmental neurobiology; developmental psychology; electroencephalography; emotions; gender difference; human puberty; human subject; longitudinal human study; middle childhood (6-11); personal log /diary; psychobiology; sleep; sleep deprivation

DESCRIPTION: (provided by applicant) Adolescence is now recognized as a period of major brain-reorganization, in addition to rapid endocrine and physical development. Among the most prominent brain changes are reductions in total sleep and a huge decline in the amplitude and abundance of the delta EEG of NREM sleep. Other brain changes in adolescence include synaptic elimination and a reduction in cortical metabolic rate. Neurodevelopmental models posit that schizophrenia may be caused or unmasked by abnormalities in these maturational processes. Daytime sleepiness emerges in adolescence, impacting mood and school performance. However, a specific within-subjectstudy of the relation of daytime sleepiness to quantitative changes in sleep EEG waveforms has not been reported. There are other major gaps in our knowledge. We do not know the within-subject rates of change in the amplitude and incidence of EEG waves in delta and other frequencies, whether 'spurts' in delta decline normally occur, the shapes of the age curves, their relation to age vs. pubertal stage, and the extent of individual and gender differences. Our research aims to fill these gaps by studying sleep longitudinally in 2 age cohorts (ages 9-13 and 12-16 years) during the period of most rapid change. Baseline and extended sleep will be studied twice/yr for 4 years. EEG waveforms will be quantified with FFT-spectral and period amplitude analyses (the 2 most widely used computer methods) and with visual sleep stage scoring. Sleepiness will be assessed with the MSLT and behavioral ratings and mood will be systematically evaluated at each time point. The proposed research will help fill major gaps in our knowledge of one of the most pronounced maturational changes of the human brain, It will also test specific hypotheses regarding the : correlates of these changes. The data we acquire could shed light on concomitant brain changes, leading to the identification of new biological relationships. Our studies will also provide benchmark data for neurodevelopmental studies in psychiatrically ill adolescents and 'at-risk' population.

描述：（由申请人提供）青春期现在被认为是一个时期 大脑重组，除了快速内分泌和物理 发展。最突出的大脑变化是总共减少 睡眠和大幅下降的幅度和丰度 nrem睡觉。青春期的其他大脑变化包括突触消除和 皮质代谢率降低。神经发育模型认为 精神分裂症可能是由于这些成熟的异常引起或揭露的 过程。白天嗜睡在青春期出现，影响情绪和学校 表现。但是，白天关系的特定主题研究 嗜睡对睡眠eeg波形的定量变化尚未 报告。 我们的知识还有其他主要差距。我们不知道主题内 三角洲和其他脑电图波的振幅和发病率的变化率 频率，是否正常出现三角洲下降中的“爆发”，形状的形状 年龄曲线，与年龄与青春期阶段的关系以及 个人和性别差异。我们的研究旨在通过 在2岁队列中纵向研究睡眠（9-13岁和12-16岁） 在最快变化的时期。基线和延长的睡眠将是 研究了两次，持续了4年。 EEG波形将通过 FFT光谱和周期振幅分析（2个最广泛使用的计算机 方法）和视觉睡眠阶段评分。嗜睡将通过 MSLT和行为评级和情绪将在 每个时间点。 拟议的研究将有助于填补我们对其中一项的了解 人脑中最明显的成熟变化，它也将测试 有关这些变化的相关性的特定假设。我们的数据 获取可能会阐明伴随的大脑变化，从而导致 识别新的生物学关系。我们的研究也将提供 精神病患神经发育研究的基准数据 青少年和“高风险”人口。