Longitudinal Measurements of Sleep EEG in Adolescence

描述（由申请人提供）：本修订版响应通知NOT-OD-09-058，竞争性修订申请的恢复法资金可用性。这项修订的家长资助纵向测量儿童和青少年的睡眠和脑电图变化。母项目的一个具体目标是建立成熟曲线，为未来研究精神疾病或发育障碍儿童的睡眠脑电图成熟提供所需的基线数据。我们正在进行的家长研究已经确定11至16岁是睡眠脑电图快速成熟的时期。我们已经将这个年龄范围内δ（1- 4 Hz）EEG功率密度下降66%解释为突触修剪驱动的青少年大脑成熟的指标。对MRI测量的皮质厚度的研究，也被认为与突触密度有关，发现注意力缺陷多动障碍（ADHD）受试者的发育滞后。此修订版应用程序的目标是测试睡眠EEG成熟存在类似滞后的假设。我们将通过研究两个年龄组（平均年龄10岁和平均年龄14岁）诊断为ADHD的受试者来验证这一假设。虽然父母资助测量青少年EEG纵向变化，但慢波EEG下降也可以在横断面分析中稳健地检测到;因此，平均年龄14岁的基线队列显示出比独立的10岁队列显著更低的δ和θ功率密度。如果ADHD儿童有发育滞后，我们假设这些年龄段ADHD组之间的EEG功率密度差异将显着较小。除了为ADHD患者睡眠电生理学的发育滞后提供初步测试外，我们将在本修订版中获得的数据应为未来ADHD患者睡眠EEG成熟的纵向研究提供指导。此外，他们将极大地扩展现有的数据基础上的计算机测量的睡眠脑电图在这种情况下。 公共卫生相关性：人类大脑在青春期经历了一次重大的重组。精神疾病可能与这种重组的异常有关。MRI研究表明，ADHD儿童在皮质发育方面存在发育滞后。我们将确定ADHD儿童是否在睡眠脑电图成熟方面表现出发育滞后。无论是阳性还是阴性结果都将扩大这种疾病的神经生理学知识。阳性结果可能具有诊断或预后价值。

DESCRIPTION (provided by applicant): This revision responds to Notice NOT-OD-09-058, Availability of Recovery Act Funds for Competitive Revision Applications. The parent grant to this revision longitudinally measures sleep and EEG changes across childhood and adolescence. One specific aim of the parent project is to establish maturational curves that will provide the baseline data needed for future studies of sleep EEG maturation in children with mental illness or developmental disorders. Our ongoing parent study has identified ages 11 to 16 years as a period of rapid sleep EEG maturation. We have interpreted the 66% decline in delta (1- 4 Hz) EEG power density over this age range as an indicator of an adolescent brain maturation driven by synaptic pruning. Studies of MRI-measured cortical thickness, also thought to be related to synaptic density, have found a developmental lag in subjects with attention deficit hyperactivity disorder (ADHD). The goal of this Revision application is to test the hypothesis that there is a similar lag in sleep EEG maturation. We will test this hypothesis by studying two age groups (mean age 10 years and mean age 14 years) of subjects diagnosed with ADHD. Although the parent grant measures the adolescent EEG changes longitudinally, the slow wave EEG decline can also be robustly detected in cross-sectional analysis; thus, cohorts in our baseline at mean age 14 years show significantly lower delta and theta power density than an independent 10 year old cohort. If children with ADHD have a developmental lag, we hypothesize that the difference in the EEG power density between ADHD groups over these ages will be significantly smaller. In addition to providing an initial test for a developmental lag in sleep electrophysiology in ADHD, the data we will obtain in this Revision should provide guidelines for future longitudinal investigations of sleep EEG maturation in ADHD. In addition, they will greatly expand the existing data base on computer-measured sleep EEG in this condition. PUBLIC HEALTH RELEVANCE: The human brain undergoes a major reorganization during adolescence. Mental illness may be associated with abnormalities in this reorganization. MRI studies show that children with ADHD have a developmental lag in cortical development. We will determine whether children with ADHD show a developmental lag in sleep EEG maturation. Either a positive or negative result will expand knowledge of the neurophysiology of this disorder. A positive result could be of diagnostic or prognostic value.