Longitudinal Measurements of Sleep EEG in Adolescence

青春期睡眠脑电图的纵向测量

• 批准号: 7811555
• 负责人: IRWIN FEINBERG
• 金额: $ 17.99万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-23 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7811555
• 关键词: 10 year old; 14 year old; 6 year old; Administrative Supplement; Adolescence; Adolescent; Age; Attention deficit hyperactivity disorder; Biocompatible Materials; Biological; Brain; Brain region; Child; Child Development; Childhood; Cognition; Computers; Control Groups; Cross-Sectional Studies; Data; Data Set; Databases; Development; Diagnosis; Diagnostic; Disease; Electroencephalography; Electrophysiology (science); Frequencies; Funding; Future; Goals; Grant; Guidelines; Home environment; Human; Investigation; Knowledge; Literature; Longitudinal Studies; Magnetic Resonance Imaging; Measures; Memory; Mental disorders; National Institute of Mental Health; Parents; Pattern; Polysomnography; Recovery; Reporting; Research Personnel; Sleep; Sleep Architecture; Synapses; Testing; Thick; Time; Work; age group; cohort; density; developmental disease; disorder control; early onset; executive function; meetings; neurophysiology; parent grant; parent project; prognostic; public health relevance

DESCRIPTION (provided by applicant): This revision responds to Notice NOT-OD-09-058, Availability of Recovery Act Funds for Competitive Revision Applications. The parent grant to this revision longitudinally measures sleep and EEG changes across childhood and adolescence. One specific aim of the parent project is to establish maturational curves that will provide the baseline data needed for future studies of sleep EEG maturation in children with mental illness or developmental disorders. Our ongoing parent study has identified ages 11 to 16 years as a period of rapid sleep EEG maturation. We have interpreted the 66% decline in delta (1- 4 Hz) EEG power density over this age range as an indicator of an adolescent brain maturation driven by synaptic pruning. Studies of MRI-measured cortical thickness, also thought to be related to synaptic density, have found a developmental lag in subjects with attention deficit hyperactivity disorder (ADHD). The goal of this Revision application is to test the hypothesis that there is a similar lag in sleep EEG maturation. We will test this hypothesis by studying two age groups (mean age 10 years and mean age 14 years) of subjects diagnosed with ADHD. Although the parent grant measures the adolescent EEG changes longitudinally, the slow wave EEG decline can also be robustly detected in cross-sectional analysis; thus, cohorts in our baseline at mean age 14 years show significantly lower delta and theta power density than an independent 10 year old cohort. If children with ADHD have a developmental lag, we hypothesize that the difference in the EEG power density between ADHD groups over these ages will be significantly smaller. In addition to providing an initial test for a developmental lag in sleep electrophysiology in ADHD, the data we will obtain in this Revision should provide guidelines for future longitudinal investigations of sleep EEG maturation in ADHD. In addition, they will greatly expand the existing data base on computer-measured sleep EEG in this condition. PUBLIC HEALTH RELEVANCE: The human brain undergoes a major reorganization during adolescence. Mental illness may be associated with abnormalities in this reorganization. MRI studies show that children with ADHD have a developmental lag in cortical development. We will determine whether children with ADHD show a developmental lag in sleep EEG maturation. Either a positive or negative result will expand knowledge of the neurophysiology of this disorder. A positive result could be of diagnostic or prognostic value.

描述(由申请人提供)：此修订响应通知NOT-OD-09-058，恢复法案资金的可用性，用于竞争性修订申请。家长对这项修订的资助纵向测量了儿童和青春期的睡眠和脑电变化。家长项目的一个具体目标是建立成熟曲线，为未来研究患有精神疾病或发育障碍的儿童的睡眠脑电成熟提供所需的基线数据。我们正在进行的父母研究发现，11至16岁是睡眠脑电快速成熟的时期。我们解释说，在这个年龄范围内，增量(1-4赫兹)脑电功率密度下降66%，是突触修剪驱动的青春期大脑成熟的指标。对核磁共振测量的皮质厚度的研究，也被认为与突触密度有关，发现注意缺陷多动障碍(ADHD)受试者存在发育滞后。这一修订应用程序的目标是测试睡眠脑电成熟过程中存在类似滞后的假设。我们将通过研究两个年龄组(平均年龄10岁和平均年龄14岁)被诊断为ADHD的受试者来检验这一假设。尽管父母的资助衡量的是青少年脑电的纵向变化，但在横断面分析中也可以很好地检测到慢波脑电下降；因此，我们基线中平均年龄为14岁的队列显示出显著低于独立10岁队列的Delta和theta功率密度。如果患有ADHD的儿童有发育迟缓，我们假设这些年龄段的ADHD组之间的脑电功率密度差异将显著较小。除了为ADHD患者睡眠电生理学的发育滞后提供初步测试外，我们在这次修订中将获得的数据应该为未来ADHD患者睡眠脑电成熟的纵向研究提供指导。此外，在这种情况下，他们将极大地扩展现有的计算机测量睡眠脑电的数据库。 与公共健康相关：人类大脑在青春期经历了一次重大重组。精神疾病可能与这种重组中的异常有关。核磁共振研究表明，ADHD儿童在皮质发育方面存在发育滞后。我们将确定ADHD儿童在睡眠脑电成熟方面是否表现出发育滞后。无论是积极的还是消极的结果都将扩大对这种疾病的神经生理学的了解。阳性结果可能具有诊断或预后价值。