Longitudinal Measurement of the Changing Sleep Need in Adolescence

青春期睡眠需求变化的纵向测量

• 批准号: 9595010
• 负责人: IRWIN FEINBERG
• 金额: $ 62.27万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9595010
• 关键词: 16 year old; Academy; Address; Adolescence; Adolescent; Adult; Age; American; Back; Basic Science; Beds; Brain; Child; Childhood; Cognition; Cognitive; Complex; Consensus; Data; Decision Making; Development; Dose; Drowsiness; Electroencephalography; Enrollment; Event; Frequencies; Goals; Habits; Health behavior; Human; Impaired health; Impairment; Investigation; Knowledge; Life; Light; Longitudinal Studies; Measurement; Measures; Medicine; Memory; Mental Health; Methods; National Heart, Lung, and Blood Institute; Neurosciences; Participant; Pattern; Performance; Problem behavior; Property; Public Health; Recommendation; Research; Scanning; Short-Term Memory; Sleep; Sleep Disorders; Teenagers; Testing; Time; Ursidae Family; adequate sleep; age effect; age related; base; cognitive function; cognitive testing; cohort; density; early adolescence; emerging adult; evidence base; evidence based guidelines; improved; indexing; interest; neurophysiology; novel; performance tests; physical conditioning; prospective; response; vigilance; young adult

Project Summary/Abstract The long-term goals of our research are to describe the age trajectories of sleep, sleep EEG, and sleep need, focusing on changes across and through adolescence. Achieving these goals will help fill major gaps in our knowledge, gaps which have direct and important implications for both public health and developmental neuroscience. Insufficient sleep and daytime sleepiness are associated with impaired physical and mental health and behavioral problems. Insufficient sleep is particularly critical during adolescence because of the profound reorganization of the human brain that takes place over the second decade of life. Despite its importance, we lack basic evidence on the quantitative relations of adolescent sleep durations to daytime sleepiness and performance. The recently released American Academy of Sleep Medicine consensus statement on adolescent sleep need was necessarily based mainly on post-hoc studies that showed correlations between poor sleep habits and impaired health and performance. Our proposed project will extend our ongoing prospective dose-response studies of the effects of varied sleep durations on daytime cognitive function, daytime sleepiness and sleep EEG patterns. The first 3 years of this study (spanning ages 10-16 years) revealed a number of interesting findings, including a divergence in the age effects of sleep duration on daytime sleepiness and daytime performance. The Continuing Renewal will extend our studies from mid-adolescence through young adulthood and allow us to determine whether the changes we observed thus far are transient maturational events or continue into adulthood. In addition to expanding the age range, the proposed continuation adds new measures and new methods of analysis of the effects of sleep duration effects on cognition. With the new additional data, the expanded study will span ages 10 to 23 years. By including the transition to young adulthood we can test rigorously the important basic science question of whether the adolescent changes in sleep duration-daytime sleepiness and performance relations are correlated with the steep adolescent decline of delta power in the NREM EEG; this decline is the most massive brain change of adolescence that can be measured non-invasively. The proposed studies will provide the first systematic longitudinal dose-response data on sleep need across this age range. Such data will begin to address the urgent need for evidence-based public health recommendations for adolescent sleep durations. Understanding the basic causes of daytime sleepiness in adolescence is a major goal of the National Center on Sleep Disorders Research of the National Heart Lung Blood Institute. The proposed studies will advance that understanding by providing the first longitudinal description of changes in sleep EEG and sleep need from late childhood through adolescence and into young adulthood. These data will also bear on the neuroscience of adolescent brain maturation.

项目摘要/摘要 我们研究的长期目标是描述睡眠、睡眠脑电和睡眠需求的年龄轨迹， 关注青春期和青春期的变化。实现这些目标将有助于填补我们在 知识、对公共卫生和发展具有直接和重要影响的差距 神经科学。睡眠不足和白天困倦与身体和精神受损有关。 健康和行为问题。睡眠不足在青春期尤为关键，因为 在生命的第二个十年里，人类大脑发生了深刻的重组。尽管它的 重要的是，我们缺乏关于青少年睡眠时间与白天数量关系的基本证据 嗜睡和表现。最近发布的美国睡眠医学学会共识 关于青少年睡眠需求的陈述主要是基于专门的研究，该研究表明 不良睡眠习惯与健康和表现受损之间的相关性。我们提议的项目将 延长我们正在进行的关于不同睡眠时间对白天影响的前瞻性剂量反应研究 认知功能、日间嗜睡和睡眠脑电模式。这项研究的前3年(跨越年龄 10-16岁)揭示了许多有趣的发现，包括睡眠对年龄的影响存在差异 日间嗜睡和日间表现的持续时间。持续的更新将扩大我们的学习 从青春期中期到青春期，让我们能够确定我们观察到的变化 到目前为止，这些都是短暂的成熟事件，或者一直持续到成年。除了扩大年龄范围外， 拟议的延续增加了分析睡眠持续时间影响的新措施和新方法 对认知的影响。有了新的额外数据，这项扩大的研究将覆盖10到23岁的年龄段。通过 包括向青壮年的过渡，我们可以严格测试重要的基础科学问题 青少年睡眠时长的变化与白天嗜睡和成绩的关系 与青少年在NREM EEG中Delta功率的急剧下降有关；这种下降是最大的 可以无创测量的青春期脑变化。拟议的研究将提供第一个 该年龄段睡眠需求的系统性纵向剂量-反应数据。这样的数据将开始 解决以证据为基础的青少年睡眠时间公共卫生建议的迫切需要。 了解青春期白天嗜睡的基本原因是国家中心的主要目标 国家心肺血液研究所睡眠障碍研究。拟议的研究将会取得进展 通过提供睡眠脑电和睡眠需求变化的第一个纵向描述来理解这一点 儿童期后期、青春期和青壮年。这些数据也将对神经科学产生影响 青春期大脑的成熟。