Longitudinal Measurement of the Changing Sleep Need in Adolescence

青春期睡眠需求变化的纵向测量

• 批准号: 9595010
• 负责人: IRWIN FEINBERG
• 金额: $ 62.27万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9595010
• 关键词: 16 year old; Academy; Address; Adolescence; Adolescent; Adult; Age; American; Back; Basic Science; Beds; Brain; Child; Childhood; Cognition; Cognitive; Complex; Consensus; Data; Decision Making; Development; Dose; Drowsiness; Electroencephalography; Enrollment; Event; Frequencies; Goals; Habits; Health behavior; Human; Impaired health; Impairment; Investigation; Knowledge; Life; Light; Longitudinal Studies; Measurement; Measures; Medicine; Memory; Mental Health; Methods; National Heart, Lung, and Blood Institute; Neurosciences; Participant; Pattern; Performance; Problem behavior; Property; Public Health; Recommendation; Research; Scanning; Short-Term Memory; Sleep; Sleep Disorders; Teenagers; Testing; Time; Ursidae Family; adequate sleep; age effect; age related; base; cognitive function; cognitive testing; cohort; density; early adolescence; emerging adult; evidence base; evidence based guidelines; improved; indexing; interest; neurophysiology; novel; performance tests; physical conditioning; prospective; response; vigilance; young adult

Project Summary/Abstract The long-term goals of our research are to describe the age trajectories of sleep, sleep EEG, and sleep need, focusing on changes across and through adolescence. Achieving these goals will help fill major gaps in our knowledge, gaps which have direct and important implications for both public health and developmental neuroscience. Insufficient sleep and daytime sleepiness are associated with impaired physical and mental health and behavioral problems. Insufficient sleep is particularly critical during adolescence because of the profound reorganization of the human brain that takes place over the second decade of life. Despite its importance, we lack basic evidence on the quantitative relations of adolescent sleep durations to daytime sleepiness and performance. The recently released American Academy of Sleep Medicine consensus statement on adolescent sleep need was necessarily based mainly on post-hoc studies that showed correlations between poor sleep habits and impaired health and performance. Our proposed project will extend our ongoing prospective dose-response studies of the effects of varied sleep durations on daytime cognitive function, daytime sleepiness and sleep EEG patterns. The first 3 years of this study (spanning ages 10-16 years) revealed a number of interesting findings, including a divergence in the age effects of sleep duration on daytime sleepiness and daytime performance. The Continuing Renewal will extend our studies from mid-adolescence through young adulthood and allow us to determine whether the changes we observed thus far are transient maturational events or continue into adulthood. In addition to expanding the age range, the proposed continuation adds new measures and new methods of analysis of the effects of sleep duration effects on cognition. With the new additional data, the expanded study will span ages 10 to 23 years. By including the transition to young adulthood we can test rigorously the important basic science question of whether the adolescent changes in sleep duration-daytime sleepiness and performance relations are correlated with the steep adolescent decline of delta power in the NREM EEG; this decline is the most massive brain change of adolescence that can be measured non-invasively. The proposed studies will provide the first systematic longitudinal dose-response data on sleep need across this age range. Such data will begin to address the urgent need for evidence-based public health recommendations for adolescent sleep durations. Understanding the basic causes of daytime sleepiness in adolescence is a major goal of the National Center on Sleep Disorders Research of the National Heart Lung Blood Institute. The proposed studies will advance that understanding by providing the first longitudinal description of changes in sleep EEG and sleep need from late childhood through adolescence and into young adulthood. These data will also bear on the neuroscience of adolescent brain maturation.

项目概要/摘要 我们研究的长期目标是描述睡眠的年龄轨迹、睡眠脑电图和睡眠需求， 关注整个青春期的变化。实现这些目标将有助于填补我们在 对公共卫生和发展有直接和重要影响的知识和差距 神经科学。睡眠不足和白天嗜睡与身心受损有关 健康和行为问题。睡眠不足在青春期尤为重要，因为 人类大脑在生命的第二个十年发生深刻的重组。尽管其 重要性，我们缺乏关于青少年睡眠持续时间与白天的定量关系的基本证据 困倦和表现。最近发布的美国睡眠医学会共识 关于青少年睡眠需求的声明必然主要基于事后研究，该研究表明 不良睡眠习惯与健康和表现受损之间的相关性。我们提出的项目将 扩展我们正在进行的关于白天不同睡眠时间影响的前瞻性剂量反应研究 认知功能、白天嗜睡和睡眠脑电图模式。本研究的前 3 年（跨越年龄 10-16 岁）揭示了许多有趣的发现，包括睡眠对年龄的影响存在差异 白天嗜睡和白天表现的持续时间。持续更新将扩展我们的学习 从青春期中期到成年早期，让我们能够确定我们观察到的变化是否 到目前为止，这些都是短暂的成熟事件或持续到成年期。除了扩大年龄范围外， 拟议的延续增加了分析睡眠持续时间影响的新措施和新方法 对认知的影响。有了新的附加数据，扩大的研究将涵盖 10 岁至 23 岁的年龄。经过 包括向青年期的过渡，我们可以严格测试重要的基础科学问题 青少年睡眠时长-日间嗜睡与表现关系的变化是否 与青少年 NREM 脑电图 delta 功率急剧下降相关；这次下降是最大幅度的 可以非侵入性测量的青春期大脑变化。拟议的研究将提供第一个 有关该年龄段睡眠需求的系统纵向剂量反应数据。此类数据将开始 解决针对青少年睡眠时间提出基于证据的公共卫生建议的迫切需要。 了解青少年白天嗜睡的基本原因是国家中心的主要目标 国家心肺血液研究所睡眠障碍研究。拟议的研究将推进 通过提供睡眠脑电图和睡眠需求变化的第一个纵向描述来理解 童年晚期到青春期直至成年早期。这些数据也将对神经科学产生影响 青少年大脑成熟的过程。