Neural Substrates of Affective Style and Emotion Regulation

描述（由申请人提供）：这是R 01-MH 43454竞争延续的修订版。本申请寻求额外五年的支持，以继续PI的情感风格和情绪调节的神经基板的研究计划。情感风格和情绪调节的个体差异决定了压力反应的变化以及对情绪、焦虑和外化障碍的脆弱性。本申请的广泛目标是进一步了解情绪调节中个体差异的神经回路，并确定负性和正性情感调节的自愿和自动形式的神经基础和生物行为相关物之间的关系。建议将这项工作扩展到青少年后期，他们是我们在过去5年中一直采用成像和行为措施跟踪的纵向样本的一部分，并且我们从出生起就有行为和激素数据。其中一项主要研究将考察消极情绪和积极情绪的自愿和自动调节之间的关系，以确定一种情绪的技能是否能预测其他情绪的技能，并确定每种情绪的神经基质是否重叠或正交，包括激活和连接措施。我们将专门讨论这样一个问题：擅长下调负面情绪的参与者是否也擅长上调正面情绪。作为本研究的一部分，我们还将研究图片引起的负性情绪和热痛引起的负性情绪的调节之间的关系。另一项研究将探讨工作记忆（WM）容量和情绪调节的个体差异之间的关系。除了评估情绪调节的任务外，参与者还将在扫描仪中接受工作记忆任务（n-back），并在WM和情绪调节任务期间确定前额叶皮层中重叠的激活区域。此外，我们将探讨工作记忆容量和自动和自愿情绪调节之间的关系。最后，使用来自威斯康星州家庭和工作研究的样本，我们将检查情绪调节的个体差异与精神病理学的症状和诊断之间的关系。我们还将把情绪调节的神经和心理生理学测量与已经收集的这些参与者的纵向数据库联系起来。这项工作将为情感风格的神经生物学研究提供重要的新信息。这些新数据将进一步加深我们对情感处理的内在表型的理解，这些表型与精神病理学的脆弱性有关。

DESCRIPTION (provided by applicant): This is a revision of the competing continuation of R01-MH43454. This application seeks five additional years of support to continue the PI's research program on the neural substrates of affective style and emotion regulation. Individual differences in affective style and emotion regulation determine variation in stress responsivity and vulnerability to mood, anxiety and externalizing disorders. The broad goal of this application is to further understand the neural circuitry underlying individual differences in emotion regulation and to determine the relation between the neural bases and biobehavioral correlates of voluntary and automatic forms of the regulation of negative and positive affect. Work is proposed that also extends this work to late adolescents who are part of a longitudinal sample that we have been following with imaging and behavioral measures for the past 5 years and on whom we have behavioral and hormonal data since birth. One major study will examine relations between voluntary and automatic regulation of both negative and positive emotion to determine if skill in one predicts skill in the others, and to determine if there is overlapping or orthogonal neural substrates of each, including activation and connectivity measures. We will specifically address the question of whether participants who are skilled at down-regulating negative affect are also skilled at upregulating positive affect. As part of this study, we will also examine relations between the regulation of picture-induced negative affect and thermal pain-induced negative affect. Another study will examine relations between individual differences in working memory (WM) capacity and emotion regulation. In addition to tasks assessing emotion regulation, participants will be given a working memory task (n-back) in the scanner and activated regions of overlap in the prefrontal cortex during the WM and emotion regulation tasks will be determined. In addition, we will examine relations between working memory capacity and automatic and voluntary emotion regulation. Finally, using a sample derived from the Wisconsin Study of Families and Work, we will examine relations between individual differences in emotion regulation and symptoms and diagnoses of psychopathology. We will also relate neural and psychophysiological measures of emotion regulation to the longitudinal corpus of data already collected on these participants. This work will provide critical new information on the neurobiology of affective style. These new data will further our understanding of endophenotypes of affective processing that are associated with vulnerability to psychopathology.