Neurobehavioral Bases of Emotion Regulation and Dysregulation in Adolescence

描述(由申请者提供)：该中心寻求支持威斯康星大学麦迪逊分校的一个高度跨学科的主要研究项目，该项目使用情感神经科学的观点来促进我们对焦虑和情绪障碍(内化性障碍)潜在的神经和行为基础的理解，特别关注青春期。青春期是这些疾病风险异常增加的时期，也是大脑功能和结构发生戏剧性成熟和经验诱导变化的时期。此外，流行病学证据表明，如果一个人在青少年时期被诊断出患有这些疾病，那么成年后患这些疾病的风险会增加2-3倍。通过一个高度集成和协作的非人类灵长类动物和人类研究项目，该项目涉及威斯康星大学麦迪逊分校的五名PI教职员工，该中心将在未来五年产生新的数据，研究情绪调节和情绪反应中个体差异的大脑机制以及行为、内分泌和自主神经相关性。重点将放在青春期大脑回路的早期生活预测指标上，这些回路是情绪调节的基础，而这些回路中的异常是容易发生内在性障碍的个体的基础。研究策略还将允许检查青春期早期疾病和后来的脆弱性之间的关系，因为在两个人类队列中都有纵向数据。在非人类队列中，将对早期应激进行明确的操作。该中心还将提供新的策略，利用大脑功能和结构的特征来分析焦虑和情绪障碍的异质性。参与该中心的每一位PI都有很长的合作历史。在PI之间有许多双向、三向和四向合作。所有人都与至少一个其他PI一起发布，许多人与许多中心PI一起发布。每个项目都涉及所有私人投资机构的协作参与。整个工作计划在很大程度上依赖于整个团队，工作范围和多层次分析只能在一个中心内进行。这个团队经验丰富，有良好的合作记录，在过去一直非常富有成效，并承诺对青少年内化障碍的神经和行为基础产生新的见解，这将直接为诊断和治疗提供信息。

DESCRIPTION (provided by applicant): This Center seeks support for a major program of highly interdisciplinary research at the University of Wisconsin-Madison that uses an affective neuroscience perspective to further our understanding of the underlying neural and behavioral bases of risk for anxiety and mood disorders (internalizing disorders), with a specific focus on the adolescent period. Adolescence is a period of extraordinarily increased risk for these disorders and it is also a period during which dramatic maturational and experience-induced alterations in brain function and structure take place. Moreover, epidemiological evidence indicates a 2-3 fold increased risk in adulthood for these disorders if an individual had a diagnosis as an adolescent. Through a highly integrated and collaborative program of research in non-human primates and humans that involves five PI's all on the faculty at UW-Madison, this Center will produce novel new data over the next five years on the brain mechanisms and behavioral, endocrine and autonomic correlates of individual differences in emotion regulation and emotional reactivity. A major focus will be on early life predictors of adolescent brain circuits that underlie the regulation of emotion and abnormalities in these circuits in individuals vulnerable to internalizing disorders. The research strategies will also permit the examination of relations between early diatheses and later vulnerability in adolescence since longitudinal data are available in both human cohorts. In the non-human cohort, an explicit manipulation of early stress will be performed. The Center will also provide new strategies for parsing the heterogeneity of anxiety and mood disorders using profiles of brain function and structure. Each of the PIs involved in this Center have a long history of collaboration. There are many two, three and four way collaborations among the PIs. All have published with at least one other PI and many have published with many of the Center PIs. Each of the projects involves the collaborative involvement of all of the PIs. This overall program of work is critically dependent upon this entire team and the scope of the work and the multiple levels of analysis would only be possible within a Center. This team is highly experienced, has a demonstrated record of working well together, has been extraordinarily productive in the past, and promises to produce novel insights about the neural and behavioral bases of adolescent internalizing disorders that will directly inform diagnosis and treatment.