Oklahoma Center of Biomedical Research Excellence (COBRE) in Structural Biology

俄克拉荷马州结构生物学生物医学卓越研究中心 (COBRE)

• 批准号: 8518419
• 负责人: ANN H WEST
• 金额: $ 187.06万
• 依托单位: UNIVERSITY OF OKLAHOMA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-01 至 2017-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8518419
• 关键词: Aging; Alzheimer' s Disease; Amyloid; Area; Award; Bacterial Infections; Biological; Biological Sciences; Biomedical Research; Cellular Membrane; Centers of Research Excellence; Chemistry; Core Facility; Crystallization; Cystic Fibrosis; Diabetes Mellitus; Drug Design; Educational workshop; Funding; GlaxoSmithKline brand of zanamivir; Goals; Grant; Health; Huntington Disease; Infection; Interdisciplinary Study; Ion Channel; Knowledge; Mentorship; Molecular Structure; Nature; Neuraminidase; Nobel Prize; Nucleic Acids; Oklahoma; Oseltamivir; Osteoporosis; Parasites; Parasitic infection; Peptides; Pharmaceutical Preparations; Postdoctoral Fellow; Process; Protein Biosynthesis; Protein-Folding Disease; Proteins; Research; Research Activity; Research Infrastructure; Research Personnel; Research Project Grants; Research Training; Resolution; Resource Sharing; Ribosomes; Scientist; Seeds; Structure; Students; Training; Universities; Viral; X-Ray Crystallography; anti-influenza; base; career development; design; human Huntingtin protein; human disease; influenzavirus; insight; instrumentation; macromolecule; multidisciplinary; programs; protein expression; protein structure; research facility; structural biology; success; symposium; three dimensional structure; zanamivir

DESCRIPTION (provided by applicant): This application proposes to establish an Oklahoma Center of Biomedical Research Excellence (COBRE) in Structural Biology. Structural biology is a multidisciplinary research area that focuses on the important relationship between macromolecular structure and function. A structural biology approach can be taken to study any area of biological science and thus it has had a major impact on both basic and applied biomedical research. At the OU-Norman and OUHSC campuses, a number of research groups utilize a structural approach to study important biological macromolecules, in particular, proteins or nucleic acids that are promising targets for rationale drug design. Because of the multidisciplinary nature of structural biology, the training of students, postdocs, and researchers new to the field can be challenging. In addition, the instrumentation required for structural biology is both expensive and sophisticated. The overall objective of this proposal is to establish an Oklahoma COBRE in Structural Biology in order to build and nurture a critical mass of researchers in this area and support their research programs through shared resources and expertise. The specific aims of this application are to: 1) Further the research activities and career development of junior investigators through senior mentorship and strengthening of research infrastructure; 2) Create state-wide core facilities in macromolecular X-ray crystallography, high throughput crystallization, and protein expression/purification, which will provide users access to shared major instrumentation, staff support and research training; and 3) Promote structural biology in the State of Oklahoma through COBRE activities such as annual symposia, workshops, a seed grant program and core research facilities. Collectively, these specific aims are expected to increase the pace, competitiveness and success rate of structural biology research groups in Oklahoma as they seek major independent external grant support.

描述(由申请者提供)：本申请建议建立俄克拉荷马州结构生物学生物医学研究卓越中心(COBRE)。结构生物学是一个多学科的研究领域，主要研究大分子结构与功能之间的重要关系。结构生物学方法可以用来研究生物科学的任何领域，因此它对基础和应用生物医学研究都产生了重大影响。在俄勒冈大学诺曼分校和俄勒冈州立大学，许多研究小组利用结构方法来研究重要的生物大分子，特别是蛋白质 或者是有希望成为基本药物设计目标的核酸。由于结构生物学的多学科性质，培养学生、博士后和研究人员 新进入这一领域可能是具有挑战性的。此外，结构生物学所需的仪器既昂贵又复杂。这项提案的总体目标是建立 俄克拉何马州科布雷的结构生物学，以建立和培养该领域的关键研究人员，并通过共享资源和专业知识支持他们的研究计划。这项应用的具体目标是：1)通过高级导师和加强研究基础设施，促进初级研究人员的研究活动和职业发展；2)创建全州范围的大分子X射线结晶学、高通量结晶和蛋白质表达/纯化的核心设施，使用户能够获得共享的主要仪器、工作人员支持和研究培训；以及3)通过Cobre活动，如年度研讨会、研讨会、种子赠款计划和核心研究设施，促进俄克拉荷马州的结构生物学。总体而言，这些具体目标预计将提高俄克拉荷马州结构生物学研究小组的速度、竞争力和成功率，因为他们正在寻求主要的独立外部资助。