Oklahoma Center of Biomedical Research Excellence (COBRE) in Structural Biology

俄克拉荷马州结构生物学生物医学卓越研究中心 (COBRE)

• 批准号: 8665999
• 负责人: ANN H WEST
• 金额: $ 198.3万
• 依托单位: UNIVERSITY OF OKLAHOMA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-01 至 2017-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8665999
• 关键词: Aging; Alzheimer' s Disease; Amyloid; Area; Award; Bacterial Infections; Biological; Biological Sciences; Biomedical Research; Cellular Membrane; Centers of Research Excellence; Chemistry; Core Facility; Crystallization; Cystic Fibrosis; Diabetes Mellitus; Drug Design; Educational workshop; Funding; GlaxoSmithKline brand of zanamivir; Goals; Grant; Health; Huntington Disease; Infection; Interdisciplinary Study; Ion Channel; Knowledge; Mentorship; Molecular Structure; Nature; Neuraminidase; Nobel Prize; Nucleic Acids; Oklahoma; Oseltamivir; Osteoporosis; Parasites; Parasitic infection; Peptides; Pharmaceutical Preparations; Postdoctoral Fellow; Process; Protein Biosynthesis; Protein-Folding Disease; Proteins; Research; Research Activity; Research Infrastructure; Research Personnel; Research Project Grants; Research Training; Resolution; Resource Sharing; Ribosomes; Scientist; Seeds; Structure; Students; Training; Universities; Viral; X-Ray Crystallography; anti-influenza; base; career development; design; human Huntingtin protein; human disease; influenzavirus; insight; instrumentation; macromolecule; multidisciplinary; programs; protein expression; protein structure; research facility; structural biology; success; symposium; three dimensional structure; zanamivir

DESCRIPTION (provided by applicant): This application proposes to establish an Oklahoma Center of Biomedical Research Excellence (COBRE) in Structural Biology. Structural biology is a multidisciplinary research area that focuses on the important relationship between macromolecular structure and function. A structural biology approach can be taken to study any area of biological science and thus it has had a major impact on both basic and applied biomedical research. At the OU-Norman and OUHSC campuses, a number of research groups utilize a structural approach to study important biological macromolecules, in particular, proteins or nucleic acids that are promising targets for rationale drug design. Because of the multidisciplinary nature of structural biology, the training of students, postdocs, and researchers new to the field can be challenging. In addition, the instrumentation required for structural biology is both expensive and sophisticated. The overall objective of this proposal is to establish an Oklahoma COBRE in Structural Biology in order to build and nurture a critical mass of researchers in this area and support their research programs through shared resources and expertise. The specific aims of this application are to: 1) Further the research activities and career development of junior investigators through senior mentorship and strengthening of research infrastructure; 2) Create state-wide core facilities in macromolecular X-ray crystallography, high throughput crystallization, and protein expression/purification, which will provide users access to shared major instrumentation, staff support and research training; and 3) Promote structural biology in the State of Oklahoma through COBRE activities such as annual symposia, workshops, a seed grant program and core research facilities. Collectively, these specific aims are expected to increase the pace, competitiveness and success rate of structural biology research groups in Oklahoma as they seek major independent external grant support.

描述（由申请人提供）：本申请建议在结构生物学中建立俄克拉荷马州生物医学研究中心（COBRE）。结构生物学是一个多学科研究领域，侧重于大分子结构与功能之间的重要关系。可以采用结构生物学方法来研究生物科学的任何领域，因此它对基本和应用生物医学研究都有重大影响。在OU-Norman和OUHSC校园中，许多研究小组都利用一种结构方法来研究重要的生物学大分子，特别是蛋白质 或核酸是有希望的基本原理药物设计靶标。由于结构生物学的多学科性质，学生，博士后和研究人员的培训 该领域的新手可能具有挑战性。此外，结构生物学所需的仪器既昂贵又精致。该提议的总体目的是建立 俄克拉荷马州的结构生物学杂种，以建立和培养该领域的重要研究人员，并通过共享的资源和专业知识来支持其研究计划。本应用的具体目的是：1）通过高级指导和加强研究基础设施的研究活动和职业发展的研究活动和职业发展； 2）在大分子X射线晶体学，高吞吐量结晶和蛋白质表达/纯化中创建全州范围的核心设施，这将为用户提供共享的主要仪器，员工支持和研究培训； 3）通过诸如年度研讨会，研讨会，种子赠款计划和核心研究设施之类的鞋布活动来促进俄克拉荷马州的结构生物学。总的来说，这些具体目标有望提高俄克拉荷马州的结构生物学研究小组的步伐，竞争力和成功率，因为​​它们寻求主要的独立外部赠款支持。