Oklahoma COBRE in Structural Biology

项目总结(整体中心) 结构生物学是一个多学科的研究领域，重点研究两者之间的重要关系 大分子结构和功能。俄克拉何马州生物医学研究卓越中心(Cobre) 结构生物学(OCSB)成立于2012年，第一阶段资金支持。OCSB支持教职员工研究 OU-Norman和OU健康科学中心校区的项目和两个研究核心设施 具有生物医学意义的大分子的结晶、X射线数据收集、蛋白质表达和 纯化和生物物理分析。此阶段3应用程序的总体目标是提供必要的 在俄克拉荷马州和该地区以共享核心设施、培训和 结构生物学方面的专业知识，以及公开竞争的试点项目计划。第三阶段的具体目标 应用是：1)维持和加强在第一阶段和第二阶段建立和发展的研究核心； 促进其向自给自足核心的过渡；2)增加该领域调查人员的临界人数 通过竞争性试点项目支持研究人员在俄克拉荷马州的结构生物学 程序。

Project Summary (Overall Center) Structural biology is a multidisciplinary research area that focuses on the important relationship between macromolecular structure and function. The Oklahoma Center of Biomedical Research Excellence (COBRE) in Structural Biology (OCSB) was established in 2012 with Phase 1 funding. The OCSB supports faculty research projects and two research core facilities on the OU-Norman and OU Health Sciences Center campuses for crystallization of macromolecules of biomedical importance, X-ray data collection, protein expression and purification and biophysical analysis. The overall objective of this Phase 3 application is to provide essential research support in the State of Oklahoma and the region in the form of shared core facilities, training and expertise in structural biology, and an open competitive pilot project program. The specific aims of this Phase 3 application are to: 1) Sustain and enhance the research cores established and developed in Phases 1 and 2 and facilitate their transition to self-sustaining cores and 2) Increase the critical mass of investigators in the field of structural biology in the State of Oklahoma by supporting researchers through a competitive pilot project program.