Oklahoma COBRE in Structural Biology

俄克拉荷马州 COBRE 结构生物学

• 批准号: 10413479
• 负责人: ANN H WEST
• 金额: $ 115.53万
• 依托单位: UNIVERSITY OF OKLAHOMA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10413479
• 关键词: Address; Area; Award; Biological Sciences; Centers of Research Excellence; Client; Communities; Consultations; Core Facility; Cryoelectron Microscopy; Crystallization; Data Collection; Development; Education and Outreach; Educational workshop; Faculty; Fees; Freezing; Funding; Goals; Grant; Group Meetings; Health Sciences; Interdisciplinary Study; Location; Mentors; Mission; Molecular Structure; Oklahoma; Paper; Peer Review; Phase; Pilot Projects; Postdoctoral Fellow; Preparation; Production; Proteins; Publishing; Research; Research Personnel; Research Project Grants; Research Support; Research Training; Resources; Roentgen Rays; Sampling; Series; Services; Structure; Students; Training; Universities; Visit; base; biophysical analysis; biophysical properties; career; experience; faculty support; human disease; insight; instrumentation; macromolecule; mid-career faculty; novel therapeutic intervention; posters; programs; protein expression; protein purification; structural biology; symposium

Project Summary (Overall Center) Structural biology is a multidisciplinary research area that focuses on the important relationship between macromolecular structure and function. The Oklahoma Center of Biomedical Research Excellence (COBRE) in Structural Biology (OCSB) was established in 2012 with Phase 1 funding. The OCSB supports faculty research projects and two research core facilities on the OU-Norman and OU Health Sciences Center campuses for crystallization of macromolecules of biomedical importance, X-ray data collection, protein expression and purification and biophysical analysis. The overall objective of this Phase 3 application is to provide essential research support in the State of Oklahoma and the region in the form of shared core facilities, training and expertise in structural biology, and an open competitive pilot project program. The specific aims of this Phase 3 application are to: 1) Sustain and enhance the research cores established and developed in Phases 1 and 2 and facilitate their transition to self-sustaining cores and 2) Increase the critical mass of investigators in the field of structural biology in the State of Oklahoma by supporting researchers through a competitive pilot project program.

项目总结（总体中心） 结构生物学是一个多学科的研究领域，其重点是 大分子结构与功能俄克拉荷马州生物医学研究卓越中心（COBRE） 结构生物学（OCSB）成立于2012年，第一阶段资金。OCSB支持教师研究 俄勒冈大学诺曼分校和俄勒冈大学健康科学中心校区的项目和两个研究核心设施， 具有生物医学重要性的大分子结晶、X射线数据收集、蛋白质表达和 纯化和生物物理分析。第三阶段申请的总体目标是提供必要的 研究支持在俄克拉荷马州和该地区的形式共享核心设施，培训和 在结构生物学的专业知识，和一个开放的竞争性试点项目计划。第三阶段的具体目标 1）维持和加强在第一和第二阶段建立和发展的研究核心， （a）促进其向自我维持核心的过渡;（b）增加调查员的必要数量， 结构生物学在俄克拉荷马州通过支持研究人员通过竞争性试点项目 程序.