Oklahoma COBRE in Structural Biology

项目总结(总体构成部分) 结构生物学是一个多学科的研究领域，重点研究两者之间的重要关系 大分子结构和功能。俄克拉荷马州生物医学研究卓越中心(科布雷) 结构生物学研究所(OCSB)成立于2012年，第一阶段资金支持。OCSB支持教职员工 OU-Norman和OU健康科学中心校区的研究项目和三个核心设施 具有生物医学意义的大分子的结晶、X射线数据收集、蛋白质表达和 纯化和生物物理分析。结构生物学位于许多不同领域的交叉点 生物科学，因此有可能对许多生物医学重要领域产生影响。这个 本文提出的研究项目与人类疾病和相关疾病有直接关系 神经退行性疾病、癌症、中风，以及慢性和急性细菌感染。整体而言 这一第二阶段应用的目标是继续建立和培养一批关键的研究人员 并通过共享资源和专业知识支持他们的研究计划。具体的 第二阶段申请的目的是：1)支持和加强研究活动和事业 通过高级指导和加强研究发展初级和早期职业调查人员 基础设施，目的是提高它们成功争取独立外部资金的能力； 2)继续提供最先进的研究核心设施，通过以下方式支持结构生物学研究人员 扩大这些核心的能力，并制定一条自我维持的道路；以及3)继续 通过OCSB赞助促进和提高结构生物学在俄克拉荷马州的可见度 年度研讨会、研讨会、试点项目计划、本科生和研究生等活动 研究和教育计划。

PROJECT SUMMARY (Overall Component) Structural biology is a multidisciplinary research area that focuses on the important relationship between macromolecular structure and function. The Oklahoma Center of Biomedical Research Excellence (COBRE) in Structural Biology (OCSB) was established in 2012 with Phase I funding. The OCSB supports faculty research projects and three core facilities on the OU-Norman and OU Health Sciences Center campuses for crystallization of macromolecules of biomedical importance, X-ray data collection, protein expression and purification and biophysical analysis. Structural biology lies at the intersection of many different areas of biological sciences and thus has the potential of impacting numerous biomedically important fields. The research projects proposed herein have direct relevance to human diseases and conditions associated with neurodegenerative diseases, cancer, stroke, and both chronic and acute bacterial infections. The overall objective of this Phase II application is to continue to build and nurture a critical mass of researchers in structural biology and support their research programs through shared resources and expertise. The specific aims of this Phase II application are to: 1) Support and augment the research activities and career development of junior and early career investigators through senior mentorship and enhanced research infrastructure with the goal of enhancing their ability to compete successfully for independent external funding; 2) Continue to provide state-of-the-art research core facilities in support of structural biology researchers by expanding the capabilities of these cores and developing a path to self-sustainability; and 3) Continue to promote and enhance the visibility of structural biology in the State of Oklahoma through OCSB-sponsored activities such as annual symposia, workshops, a pilot project program, and undergraduate and graduate research and education programs.