Oklahoma COBRE in Structural Biology

项目概要（总体组成部分） 结构生物学是一个多学科的研究领域，其重点是 大分子结构与功能俄克拉荷马州生物医学研究卓越中心（COBRE） 在结构生物学（OCSB）成立于2012年与第一阶段的资金。OCSB支持教师 研究项目和三个核心设施上的OU-Norman和ESTA健康科学中心校园， 具有生物医学重要性的大分子结晶、X射线数据收集、蛋白质表达和 纯化和生物物理分析。结构生物学处于许多不同领域的交叉点， 生物科学，因此具有影响许多生物医学重要领域的潜力。的 本文提出的研究项目与人类疾病和与之相关的病症直接相关， 神经退行性疾病、癌症、中风以及慢性和急性细菌感染。整体 第二阶段申请的目标是继续建立和培养一批关键的研究人员， 结构生物学，并通过共享资源和专业知识支持他们的研究计划。具体 第二阶段申请的目的是：1）支持和加强研究活动和职业生涯 通过高级指导和加强研究，培养初级和早期职业调查员 基础设施，目标是提高其成功竞争独立外部资金的能力; 2)继续提供最先进的研究核心设施，以支持结构生物学研究人员， 扩大这些核心的能力，并发展自我可持续性的道路; 3）继续 促进和提高结构生物学在俄克拉荷马州的能见度，通过OCSB赞助 活动，如年度研讨会，研讨会，试点项目计划，本科生和研究生 研究和教育计划。

PROJECT SUMMARY (Overall Component) Structural biology is a multidisciplinary research area that focuses on the important relationship between macromolecular structure and function. The Oklahoma Center of Biomedical Research Excellence (COBRE) in Structural Biology (OCSB) was established in 2012 with Phase I funding. The OCSB supports faculty research projects and three core facilities on the OU-Norman and OU Health Sciences Center campuses for crystallization of macromolecules of biomedical importance, X-ray data collection, protein expression and purification and biophysical analysis. Structural biology lies at the intersection of many different areas of biological sciences and thus has the potential of impacting numerous biomedically important fields. The research projects proposed herein have direct relevance to human diseases and conditions associated with neurodegenerative diseases, cancer, stroke, and both chronic and acute bacterial infections. The overall objective of this Phase II application is to continue to build and nurture a critical mass of researchers in structural biology and support their research programs through shared resources and expertise. The specific aims of this Phase II application are to: 1) Support and augment the research activities and career development of junior and early career investigators through senior mentorship and enhanced research infrastructure with the goal of enhancing their ability to compete successfully for independent external funding; 2) Continue to provide state-of-the-art research core facilities in support of structural biology researchers by expanding the capabilities of these cores and developing a path to self-sustainability; and 3) Continue to promote and enhance the visibility of structural biology in the State of Oklahoma through OCSB-sponsored activities such as annual symposia, workshops, a pilot project program, and undergraduate and graduate research and education programs.