Oklahoma COBRE in Structural Biology

俄克拉荷马州 COBRE 结构生物学

• 批准号: 10197142
• 负责人: ANN H WEST
• 金额: $ 211.29万
• 依托单位: UNIVERSITY OF OKLAHOMA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10197142
• 关键词: Acute; Area; Award; Bacterial Infections; Biological Sciences; Businesses; Centers of Research Excellence; Chronic; Communities; Core Facility; Crystallization; Data Collection; Development; Disease; Education; Education and Outreach; Educational workshop; Ensure; Equipment; Evaluation; Extramural Activities; Faculty; Funding; Future; Goals; Grant; Health Sciences; Interdisciplinary Study; Malignant Neoplasms; Mentors; Mentorship; Molecular Structure; Neurodegenerative Disorders; Oklahoma; Paper; Peer Review; Phase; Pilot Projects; Postdoctoral Fellow; Preparation; Production; Proteins; Publishing; Research; Research Activity; Research Infrastructure; Research Personnel; Research Project Grants; Research Training; Resource Sharing; Roentgen Rays; Sampling; Stroke; Structure; Students; Training; biomedical resource; biophysical analysis; career; career development; faculty support; human disease; instrumentation; macromolecule; novel therapeutics; posters; programs; protein expression; protein purification; structural biology; symposium; undergraduate student

PROJECT SUMMARY (Overall Component) Structural biology is a multidisciplinary research area that focuses on the important relationship between macromolecular structure and function. The Oklahoma Center of Biomedical Research Excellence (COBRE) in Structural Biology (OCSB) was established in 2012 with Phase I funding. The OCSB supports faculty research projects and three core facilities on the OU-Norman and OU Health Sciences Center campuses for crystallization of macromolecules of biomedical importance, X-ray data collection, protein expression and purification and biophysical analysis. Structural biology lies at the intersection of many different areas of biological sciences and thus has the potential of impacting numerous biomedically important fields. The research projects proposed herein have direct relevance to human diseases and conditions associated with neurodegenerative diseases, cancer, stroke, and both chronic and acute bacterial infections. The overall objective of this Phase II application is to continue to build and nurture a critical mass of researchers in structural biology and support their research programs through shared resources and expertise. The specific aims of this Phase II application are to: 1) Support and augment the research activities and career development of junior and early career investigators through senior mentorship and enhanced research infrastructure with the goal of enhancing their ability to compete successfully for independent external funding; 2) Continue to provide state-of-the-art research core facilities in support of structural biology researchers by expanding the capabilities of these cores and developing a path to self-sustainability; and 3) Continue to promote and enhance the visibility of structural biology in the State of Oklahoma through OCSB-sponsored activities such as annual symposia, workshops, a pilot project program, and undergraduate and graduate research and education programs.

项目摘要（整体组成部分）

项目成果

miR-18a and miR-106a Signatures in Plasma Small EVs Are Promising Biomarkers for Early Detection of Pancreatic Ductal Adenocarcinoma.

• DOI: 10.3390/ijms24087215
• 发表时间: 2023-04-13
• 期刊: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
• 影响因子: 5.6
• 作者: Xu, Xiaohui;Bhandari, Kritisha;Xu, Chao;Morris, Katherine;Ding, Wei-Qun
• 通讯作者: Ding, Wei-Qun

Structural and functional insights into the bona fide catalytic state of Streptococcus pyogenes Cas9 HNH nuclease domain

• DOI: 10.7554/elife.46500
• 发表时间: 2019-07
• 期刊: eLife
• 影响因子: 7.7
• 作者: Zhicheng Zuo;A. Zolekar;Kesavan Babu;Victor. J. T. Lin;Hamed S. Hayatshahi;R. Rajan;Yu-Chieh Wang;Jin Liu

Isolation of extra-cellular vesicles in the context of pancreatic adenocarcinomas: Addition of one stringent filtration step improves recovery of specific microRNAs.

• DOI: 10.1371/journal.pone.0259563
• 发表时间: 2021
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Xu YF;Xu X;Bhandari K;Gin A;Rao CV;Morris KT;Hannafon BN;Ding WQ
• 通讯作者: Ding WQ

Targeting RNA Structure to Inhibit Editing in Trypanosomes.

• DOI: 10.3390/ijms241210110
• 发表时间: 2023-06-14
• 期刊: International journal of molecular sciences
• 影响因子: 5.6

PEGylation of Polyethylenimine Lowers Acute Toxicity while Retaining Anti-Biofilm and β-Lactam Potentiation Properties against Antibiotic-Resistant Pathogens.

• DOI: 10.1021/acsomega.0c04111
• 发表时间: 2020-10-13
• 期刊: ACS omega
• 影响因子: 4.1
• 作者: Lam AK;Moen EL;Pusavat J;Wouters CL;Panlilio H;Ferrell MJ;Houck MB;Glatzhofer DT;Rice CV
• 通讯作者: Rice CV