NATIONAL BIOMEDICAL COMPUTATION RESOURCE

NBCR的首要任务是通过利用前沿的计算和信息技术来指导、促进和实现生物医学研究，并重点关注转化和多尺度研究。在未来的五年里，我们看到生物医学研究的巨大机遇，因为信息技术的持续革命和计算机可用性的丰富。我们的目标是推进我们对多尺度生物医学方法的理解的前沿；提供有意义的翻译结果；加快生物医学科学界采用和发展新兴信息技术；继续加强多学科的资源；并在翻译研究的关键领域建立多学科的合作者和用户社区。我们通过一系列相互关联的活动来实现这些目标：以透明的方式整合计算、数据和可视化资源，以便更好地访问分布式数据、计算资源、仪器和人员；开发和部署用于模型构建和仿真、三维图像处理和交互式可视化的先进计算工具和软件包；为生物医学研究人员提供和支持先进的网络基础设施工具和环境。培养一批新的研究人员，使他们具备实验生物学和与生物医学科学家相关的计算技术的跨学科的工作知识。

NBCR's overarching mission is to conduct, catalyze, and enable biomedical research by harnessing forefront computational and information technologies, with a strong focus on translational and multiscale research. In the coming five years we see tremendous opportunities in biomedical research because of the continuing revolution in information technology and the abundance of computing availability. Our objectives are to advance the frontiers of our understanding in multiscale biomedical approaches; provide translational results of significance; accelerate the adoption and development of emerging information technologies by the, biomedical science community; continue to strengthen the multidisciplinarity of the resource; and create multidisciplinary communities of collaborators and users in key areas of translational research. We accomplish these goals through an interrelated set of activities: Integrate computational, data and visualization resources in a transparent way to enable better access to distributed data, computational resources, instruments and people; Develop and deploy advanced computational tools and packages for model building and simulation, three-dimensional image processing, and interactive visualization; Deliver and support advanced cyberinfrastructure tools and environments for biomedical researchers. Train a cadre of new researchers such that they have an interdisciplinary, working knowledge both of experimental biology and of computational technology relevant to biomedical scientists. In this renewal our core technology research and development activities will focus on three themes: 1. Multiscale Model Building and Visualization Tools, for data refinement, visual workflows, mathematical and visual modeling, available in appropriate toolkits and simulation packages. 2. Multiscale Simulation Software Packages and Pipelines for targeted biomedical and translational research to gain those insights into key biomedical processes and diseases, building on NBCR and partner tools and utilizing the cyberinfrastructure. 3. Flexible. Scalable Cvberinfrastructure Framework, to address practical issues of adopting and optimizing some exemplar biomedical applications to the current and emerging cyberinfrastructure while ensuring scientific reproducibility. These developments are driven by collaborative projects on translational research, and have broader impact on the community via service project that use our tools, training on our tools, and dissemination.