Multiscale Computational Microscopy of HIV-1
HIV-1 的多尺度计算显微镜
基本信息
- 批准号:10756808
- 负责人:
- 金额:$ 71.39万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-07-07 至 2028-06-30
- 项目状态:未结题
- 来源:
- 关键词:2019-nCoVAIDS preventionAcquired Immunodeficiency SyndromeAddressAntigensBackBiologyCellsChimeric ProteinsCollaborationsCrowdingCryo-electron tomographyCryoelectron MicroscopyDataData SetDiseaseElementsExhibitsFuture GenerationsGlycocalyxGoalsHIVHIV vaccineHIV-1Heparitin SulfateHumanImmune systemInfectionInfection preventionInfluenzaKnowledgeLinkMethodsMicroscopeMicroscopyModelingMolecular StructureMucinsMutateOutcomePatternPersonsPhysiologicalPlayPolysaccharidesPost-Translational Protein ProcessingProtein DynamicsRNAResolutionRetroviridaeScientistSeriesSiteStructural BiologistStructureSurfaceTechniquesTherapeuticTimeTranslatingUnited States National Institutes of HealthUtahVaccinesViralViral Fusion ProteinsViral ProteinsVirionVirusadvanced simulationdensitydesignenv Gene Productsexperimental studyflexibilityimmunogenicimprovedin vivoinfection rateinsightinterestmodel buildingmolecular dynamicsnovelreceptorsimulationsmall moleculestructural biology
项目摘要
ABSTRACT
The human immunodeficiency virus 1 (HIV-1) is the RNA retrovirus that causes acquired
immunodeficiency syndrome (AIDS), a disease that has killed over 40 million people worldwide
and infected more than twice that. Continued high infection rates has made understanding of
HIV biology and vaccines a high priority. A key molecule involved in both infection and vaccine
efforts is the HIV-1 Envelope protein (Env). Experimental structural biology techniques have
characterized the basic structure of Env, but they are unable to provide details about the
extensive N-linked glycan shield nor inform on the flexibility and dynamics of Env. In this
proposal, we envision using all-atom molecular dynamics simulations as a `computational
microscope,' to provide insights into the dynamics of Env that are unattainable with current
experimental techniques. Together with top flight experimentalists, we will develop and simulate
a series of models to explore the dynamics of Env as well as its interactions with co-receptors
and the cell glycocalyx, in unprecedented detail. In addition, we will use advanced simulation
techniques to optimize immunogen design as well as provide critical information about hitherto
unseen druggable sites in Env.
摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Rommie E Amaro其他文献
Rommie E Amaro的其他文献
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{{ truncateString('Rommie E Amaro', 18)}}的其他基金
A MULTISCALE APPROACH TO TARGET THE ACHILLES HEEL OF P53 CANCER MUTANTS
针对 P53 癌症突变体致命弱点的多尺度方法
- 批准号:
10391499 - 财政年份:2019
- 资助金额:
$ 71.39万 - 项目类别:
A MULTISCALE APPROACH TO TARGET THE ACHILLES HEEL OF P53 CANCER MUTANTS
针对 P53 癌症突变体致命弱点的多尺度方法
- 批准号:
9906241 - 财政年份:2019
- 资助金额:
$ 71.39万 - 项目类别:
AN OPEN RESOURCE TO ADVANCE COMPUTER-AIDED DRUG DESIGN
推进计算机辅助药物设计的开放资源
- 批准号:
8756082 - 财政年份:2014
- 资助金额:
$ 71.39万 - 项目类别:
Towards a Structural Systems Biology Approach for Anti-Trypanosomal Therapeutics
抗锥虫治疗的结构系统生物学方法
- 批准号:
7791099 - 财政年份:2010
- 资助金额:
$ 71.39万 - 项目类别:
Towards a Structural Systems Biology Approach for Anti-Trypanosomal Therapeutics
抗锥虫治疗的结构系统生物学方法
- 批准号:
8122149 - 财政年份:2010
- 资助金额:
$ 71.39万 - 项目类别:
A Structural Systems Biology Approach to Drug Discovery
药物发现的结构系统生物学方法
- 批准号:
8798517 - 财政年份:2010
- 资助金额:
$ 71.39万 - 项目类别:
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