Advancing Competitive Biomedical Research in Puerto Rico

推进波多黎各有竞争力的生物医学研究

• 批准号: 8478147
• 负责人: JOSE R RODRIGUEZ-MEDINA
• 金额: $ 337.47万
• 依托单位: UNIVERSITY OF PUERTO RICO
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-15 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8478147
• 关键词: Active Sites; Address; Advisory Committees; Affect; Area; Award; Binding; Bioinformatics; Biological; Biomedical Research; Bioreactors; Cell Wall; Cell membrane; Centers of Research Excellence; Chemicals; Collaborations; Competence; Complement; Complex; Consult; Continuing Education; Cyclodextrins; Cytoplasm; Cytoskeleton; Dehydration; Development; Digit structure; Disease; Drug Design; Education; Educational workshop; Electron Spin Resonance Spectroscopy; Electronics; Energy Transfer; Ensure; Environment; Enzyme Stability; Enzymes; Ethylene Glycols; Etiology; Evaluation; Exhibits; Exposure to; Faculty; Fluorine; Fostering; Freeze Drying; Gene Expression; Genes; Goals; Grant; Growth; Hela Cells; Hour; Human Resources; Hydration status; Hydrolase; Immobilization; Immobilized Enzymes; Institution; Internships; Intervention; Island; Kentucky; Liquid substance; Long-Term Effects; Malignant Neoplasms; Measures; Mechanics; Medical; Membrane; Mentors; Metals; Methodology; Methods; Modification; Molecular; Molecular Medicine; Movement; National Center for Research Resources; Neurosciences; Nuclear Magnetic Resonance; Nucleic Acids; Organic solvent product; Performance; Pharmacologic Substance; Piedra; Plasma; Process; Productivity; Protein Dynamics; Published Comment; Puerto Rico; RNA; RNA Stability; Reaction; Research; Research Infrastructure; Research Project Grants; Role; Science; Series; Services; Solutions; Solvents; Spin Labels; Structure; Students; Surface; Technical Expertise; Techniques; Technology; Technology Transfer; Theoretical Studies; Time; Virus Diseases; Water; Work; aqueous; base; career; catalyst; design; enzyme activity; ethylene glycol; flexibility; improved; insight; instrumentation; interest; knowledge base; macromolecule; molecular dynamics; nucleic acid stability; programs; quantum; research study; simulation; undergraduate student

This renewal of PRAABRE represents a step forward in our efforts to foster the continued development of the biomedical research infrastructure in Puerto Rico. Such continued development is achieved through the implementation of a strengthened and cohesive structure with improved integration of common scientific and educational interests, collaborations, and a newly created Mentoring Initiative. The structure of PRAABRE is represented in the following components: Administrative, Bioinformatics, Scientific Network, Centralized Research and Instrumentation, and Science and Technology and Education. The Administrative Core provides the programmatic direction for the entire PRAABRE. The new Mentoring Initiative will standardize mentoring practices among participating Institutions at all levels of intervention, from undergraduate student research to mentored research at the faculty level. This initiative will also coordinate Grantsmanship Workshops offered by Kentucky INBRE personnel on a yearly basis. The Administrative Core, via a close interaction with the External Advisory Committee and an External Independent Evaluator, will also organize the overall formative and additive evaluation process of PRAABRE. The Bioinformatics Core will assertively foster and stimulate the development of bioinformatics research, collaborations, and consulting services. This core will also be responsible for maintaining high performance lnternet-2 network capabilities at participating Institutions. Our initiative for providing Access to Biomedical Research Electronic Information will also be coordinated by the Bioinformatics Core. The Scientific Network will host 11 INBRE sponsored research projects in PRAABRE, all organized into thrust areas within the biomedical sciences. The Centralized Research and Instrumentation Core integrates the corresponding facilities established at the UPR-Rio Piedras and Medical Sciences Campuses by prior BRIN and INBRE cycles, as well as by COBRE and RCMI, all NCRR programs. The Science and Technology Competene and Education Core will host the PRAABRE Seminar Series, Technology Transfer Awards, Faculty Summer Internships, Continued Education and Technology Competence Workshops, and the Science-on-Wheels project, a K-12 initiative. This PRAABRE Core will also help coordinate Summer Internships in Kentucky for PRAABRE students, an Initiative covered by the Kentucky INBRE. A special quality of this renewal application is the collaborations among the distinct cores, which makes the proposed efforts a true networking of ideas, education, and biomedical research in the Island of Puerto Rico.

Praabre的这种更新代表了我们努力促进波多黎各生物医学研究基础设施的持续发展迈出的一步。通过实施加强和凝聚力的结构，通过改善了共同的科学和教育利益，合作以及新创建的指导计划的整合来实现这种持续的发展。 Praabre的结构在以下组成部分中表示：行政，生物信息学，科学网络，集中研究和仪器以及科学与技术和教育。管理核心为整个Praabre提供了程序化方向。新的指导倡议将在各个干预层面的参与机​​构中标准化指导实践，从本科生研究到教师的指导研究。该倡议还将协调肯塔基州INBRE人员每年提供的赠款讲习班。通过与外部咨询委员会和外部独立评估者进行密切互动，行政核心还将组织Praabre的整体形成性和添加剂评估过程。生物信息学核心将肯定地促进和刺激生物信息学研究，协作和咨询服务的发展。该核心还将负责维持参与机构的高性能LNTernet-2网络能力。我们提供生物医学研究电子信息访问的计划也将由生物信息学核心协调。该科学网络将在Praabre举办11个INBRE赞助的研究项目，所有这些都组织成生物医学科学内的推力区域。集中的研究和仪器核心整合了先前的Brin和Inbre Cycles以及Cobre和RCMI在UPR-Rio Piedras和医学科学校园建立的相应设施，所有NCRR计划。科学和技术竞争和教育核心将主持Praabre研讨会系列，技术转移奖，暑期实习，持续的教育和技术能力讲习班以及K-12的Science-Wheels Project，这是K-12倡议。这个Praabre核心还将帮助协调肯塔基州Praabre学生的暑期实习，这是由肯塔基州INBRE涵盖的一项倡议。这种续签应用的特殊质量是不同核心之间的合作，这使得拟议的努力成为波多黎各岛上的思想，教育和生物医学研究的真正网络。

项目成果

Nonsense mutations of the bHLH transcription factor TWIST2 found in Setleis Syndrome patients cause dysregulation of periostin.

• DOI: 10.1016/j.biocel.2011.07.003
• 发表时间: 2011-10
• 期刊: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
• 影响因子: 4
• 作者: Franco, Hector L.;Casasnovas, Jose J.;Leon, Ruth G.;Friesel, Robert;Ge, Yongchao;Desnick, Robert J.;Cadilla, Carmen L.
• 通讯作者: Cadilla, Carmen L.

A ten-year assessment of anabolic steroid misuse among competitive athletes in Puerto Rico.

对波多黎各竞技运动员滥用合成代谢类固醇的十年评估。

• 发表时间: 2011
• 期刊: The West Indian medical journal
• 作者: Acevedo,P;Jorge,JC;Cruz-Sanchez,A;Amy,E;Barreto-Estrada,JL
• 通讯作者: Barreto-Estrada,JL

Sex-specific modulation of anxiety and locomotion after neonatal exposure to pregnenolone sulfate.

新生儿接触孕烯醇酮硫酸盐后焦虑和运动的性别特异性调节。

• DOI: 10.1016/j.physbeh.2004.09.017
• 发表时间: 2005
• 期刊: Physiology & behavior.
• 作者: Jorge,JuanCarlos;Gonzalez,Loida;Fortis,Azarhi;Cruz,NelsonD
• 通讯作者: Cruz,NelsonD

Photosensitized oxidation of hypoxanthine and xanthine by aluminum phthalocyanine tetrasulfonate. Role of the alkylating quinone 2,5-dichloro-diaziridinyl-1,4-benzoquinone.

酞菁四磺酸铝光敏氧化次黄嘌呤和黄嘌呤。

• DOI: 10.1111/j.1751-1097.2008.00389.x
• 发表时间: 2008
• 期刊: Photochemistry and photobiology
• 影响因子: 3.3
• 作者: Alegria,AntonioE;Inostroza,Yaritza;Kumar,Ajay
• 通讯作者: Kumar,Ajay

Kinin-B2 receptor exerted neuroprotection after diisopropylfluorophosphate-induced neuronal damage.

• DOI: 10.1016/j.neuroscience.2013.05.054
• 发表时间: 2013-09-05
• 期刊: Neuroscience
• 影响因子: 3.3
• 作者: Torres-Rivera W;Pérez D;Park KY;Carrasco M;Platt MO;Eterović VA;Ferchmin PA;Ulrich H;Martins AH
• 通讯作者: Martins AH