Advancing Competitive Biomedical Research in Puerto Rico

推进波多黎各有竞争力的生物医学研究

• 批准号: 8478147
• 负责人: JOSE R RODRIGUEZ-MEDINA
• 金额: $ 337.47万
• 依托单位: UNIVERSITY OF PUERTO RICO
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-15 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8478147
• 关键词: Active Sites; Address; Advisory Committees; Affect; Area; Award; Binding; Bioinformatics; Biological; Biomedical Research; Bioreactors; Cell Wall; Cell membrane; Centers of Research Excellence; Chemicals; Collaborations; Competence; Complement; Complex; Consult; Continuing Education; Cyclodextrins; Cytoplasm; Cytoskeleton; Dehydration; Development; Digit structure; Disease; Drug Design; Education; Educational workshop; Electron Spin Resonance Spectroscopy; Electronics; Energy Transfer; Ensure; Environment; Enzyme Stability; Enzymes; Ethylene Glycols; Etiology; Evaluation; Exhibits; Exposure to; Faculty; Fluorine; Fostering; Freeze Drying; Gene Expression; Genes; Goals; Grant; Growth; Hela Cells; Hour; Human Resources; Hydration status; Hydrolase; Immobilization; Immobilized Enzymes; Institution; Internships; Intervention; Island; Kentucky; Liquid substance; Long-Term Effects; Malignant Neoplasms; Measures; Mechanics; Medical; Membrane; Mentors; Metals; Methodology; Methods; Modification; Molecular; Molecular Medicine; Movement; National Center for Research Resources; Neurosciences; Nuclear Magnetic Resonance; Nucleic Acids; Organic solvent product; Performance; Pharmacologic Substance; Piedra; Plasma; Process; Productivity; Protein Dynamics; Published Comment; Puerto Rico; RNA; RNA Stability; Reaction; Research; Research Infrastructure; Research Project Grants; Role; Science; Series; Services; Solutions; Solvents; Spin Labels; Structure; Students; Surface; Technical Expertise; Techniques; Technology; Technology Transfer; Theoretical Studies; Time; Virus Diseases; Water; Work; aqueous; base; career; catalyst; design; enzyme activity; ethylene glycol; flexibility; improved; insight; instrumentation; interest; knowledge base; macromolecule; molecular dynamics; nucleic acid stability; programs; quantum; research study; simulation; undergraduate student

This renewal of PRAABRE represents a step forward in our efforts to foster the continued development of the biomedical research infrastructure in Puerto Rico. Such continued development is achieved through the implementation of a strengthened and cohesive structure with improved integration of common scientific and educational interests, collaborations, and a newly created Mentoring Initiative. The structure of PRAABRE is represented in the following components: Administrative, Bioinformatics, Scientific Network, Centralized Research and Instrumentation, and Science and Technology and Education. The Administrative Core provides the programmatic direction for the entire PRAABRE. The new Mentoring Initiative will standardize mentoring practices among participating Institutions at all levels of intervention, from undergraduate student research to mentored research at the faculty level. This initiative will also coordinate Grantsmanship Workshops offered by Kentucky INBRE personnel on a yearly basis. The Administrative Core, via a close interaction with the External Advisory Committee and an External Independent Evaluator, will also organize the overall formative and additive evaluation process of PRAABRE. The Bioinformatics Core will assertively foster and stimulate the development of bioinformatics research, collaborations, and consulting services. This core will also be responsible for maintaining high performance lnternet-2 network capabilities at participating Institutions. Our initiative for providing Access to Biomedical Research Electronic Information will also be coordinated by the Bioinformatics Core. The Scientific Network will host 11 INBRE sponsored research projects in PRAABRE, all organized into thrust areas within the biomedical sciences. The Centralized Research and Instrumentation Core integrates the corresponding facilities established at the UPR-Rio Piedras and Medical Sciences Campuses by prior BRIN and INBRE cycles, as well as by COBRE and RCMI, all NCRR programs. The Science and Technology Competene and Education Core will host the PRAABRE Seminar Series, Technology Transfer Awards, Faculty Summer Internships, Continued Education and Technology Competence Workshops, and the Science-on-Wheels project, a K-12 initiative. This PRAABRE Core will also help coordinate Summer Internships in Kentucky for PRAABRE students, an Initiative covered by the Kentucky INBRE. A special quality of this renewal application is the collaborations among the distinct cores, which makes the proposed efforts a true networking of ideas, education, and biomedical research in the Island of Puerto Rico.

PRAABRE的这一更新标志着我们在努力促进波多黎各生物医学研究基础设施的持续发展方面向前迈出了一步。这样的持续发展是通过实施一个加强的和有凝聚力的结构，改进了共同的科学和教育利益的整合、合作和新创建的指导倡议来实现的。PRAABRE的结构体现在以下组成部分：行政、生物信息学、科学网络、中央研究和仪器以及科学和技术与教育。管理核心为整个PRAABRE提供规划方向。新的辅导倡议将标准化各级参与机构的辅导做法，从本科生研究到教职员工层面的辅导研究。这一倡议还将协调肯塔基州INBRE人员每年举办的格兰茨基尔研讨会。行政核心还将通过与外部咨询委员会和一名外部独立评价人员的密切互动，组织整个PRAABRE的形成性和累加性评价过程。生物信息学核心将坚定地促进和刺激生物信息学研究、合作和咨询服务的发展。这一核心还将负责维持参与机构的高性能互联网-2网络能力。我们提供生物医学研究电子信息的倡议也将由生物信息学核心协调。科学网络将在PRAABRE主办11个由INBRE赞助的研究项目，所有这些项目都被安排在生物医学科学的主要领域。中央研究和仪器核心整合了之前的Brin和INBRE周期以及Cobre和RCMI在UPR-Rio Piedras和医学科学园区建立的相应设施，这些都是NCRR计划。科学和技术竞争力和教育核心将主办PRAABRE研讨会系列、技术转移奖、教师暑期实习、继续教育和技术能力研讨会，以及K-12倡议的轮上科学项目。这个PRAABRE核心还将帮助协调PRAABRE学生在肯塔基州的暑期实习，这是肯塔基州INBRE涵盖的一项倡议。这一续签申请的一个特殊特点是不同核心之间的合作，这使得拟议的努力成为波多黎各岛上思想、教育和生物医学研究的真正网络。

项目成果

Nonsense mutations of the bHLH transcription factor TWIST2 found in Setleis Syndrome patients cause dysregulation of periostin.

• DOI: 10.1016/j.biocel.2011.07.003
• 发表时间: 2011-10
• 期刊: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
• 影响因子: 4
• 作者: Franco, Hector L.;Casasnovas, Jose J.;Leon, Ruth G.;Friesel, Robert;Ge, Yongchao;Desnick, Robert J.;Cadilla, Carmen L.
• 通讯作者: Cadilla, Carmen L.

Sex-specific modulation of anxiety and locomotion after neonatal exposure to pregnenolone sulfate.

新生儿接触孕烯醇酮硫酸盐后焦虑和运动的性别特异性调节。

• DOI: 10.1016/j.physbeh.2004.09.017
• 发表时间: 2005
• 期刊: Physiology & behavior.
• 作者: Jorge,JuanCarlos;Gonzalez,Loida;Fortis,Azarhi;Cruz,NelsonD
• 通讯作者: Cruz,NelsonD

Photosensitized oxidation of hypoxanthine and xanthine by aluminum phthalocyanine tetrasulfonate. Role of the alkylating quinone 2,5-dichloro-diaziridinyl-1,4-benzoquinone.

酞菁四磺酸铝光敏氧化次黄嘌呤和黄嘌呤。

• DOI: 10.1111/j.1751-1097.2008.00389.x
• 发表时间: 2008
• 期刊: Photochemistry and photobiology
• 影响因子: 3.3
• 作者: Alegria,AntonioE;Inostroza,Yaritza;Kumar,Ajay
• 通讯作者: Kumar,Ajay

A ten-year assessment of anabolic steroid misuse among competitive athletes in Puerto Rico.

对波多黎各竞技运动员滥用合成代谢类固醇的十年评估。

• 发表时间: 2011
• 期刊: The West Indian medical journal
• 作者: Acevedo,P;Jorge,JC;Cruz-Sanchez,A;Amy,E;Barreto-Estrada,JL
• 通讯作者: Barreto-Estrada,JL

Kinin-B2 receptor exerted neuroprotection after diisopropylfluorophosphate-induced neuronal damage.

• DOI: 10.1016/j.neuroscience.2013.05.054
• 发表时间: 2013-09-05
• 期刊: Neuroscience
• 影响因子: 3.3
• 作者: Torres-Rivera W;Pérez D;Park KY;Carrasco M;Platt MO;Eterović VA;Ferchmin PA;Ulrich H;Martins AH
• 通讯作者: Martins AH