ACTIVITY 2: ENHANCEMENT OF INSTITUTIONAL RESEARCH CAPACITY IN MOLECULAR GENETICS

活动 2：增强分子遗传学机构研究能力

• 批准号: 7336039
• 负责人: JOSE R RODRIGUEZ-MEDINA
• 金额: $ 9.77万
• 依托单位: UNIVERSITY OF PUERTO RICO MED SCIENCES
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7336039
• 关键词: human; molecular biology; molecular genetics; training

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Because of their close interaction and complementing infrastructures, we proposed that the Molecular Biology Core Facility and the Human Molecular Genetics Unit previously established at the University of Puerto Rico Medical Sciences Campus (UPR-MSC) be fused into a single core facility called the Molecular Genetics Core Facility (MGCF). The goal of this facility was to enhance our institutional biomedical research capability by supporting basic and clinically oriented projects with strong molecular biology and molecular genetics components. To fulfill this goal, we proposed the following specific aims. 1. To provide the infrastructure necessary to sustain the research currently conducted in molecular genetics at the MSC especially those projects that address health disparities. 2. To increase the critical mass of research projects in molecular biology and genetics conducted at the MSC by training graduate and undergraduate students in these areas. 3. To continue to make available new methodologies in molecular genetics that can be used for analysis of the human genome by providing specialized training in molecular genetics to faculty and staff members. 4. To develop a system for genotyping and/or DNA sequencing of nucleic acids derived from humans and other sources.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。由于其密切的相互作用和互补的基础设施，我们建议，分子生物学核心设施和人类分子遗传学单位先前建立在波多黎各大学医学科学校园（UPR-MSC）融合成一个单一的核心设施，称为分子遗传学核心设施（MGCF）。该设施的目标是通过支持具有强大分子生物学和分子遗传学组成部分的基础和临床项目，提高我们的机构生物医学研究能力。为实现这一目标，我们提出了以下具体目标。 1.提供必要的基础设施，以维持目前在MSC进行的分子遗传学研究，特别是那些解决健康差异的项目。 2.通过培训这些领域的研究生和本科生，增加在MSC进行的分子生物学和遗传学研究项目的临界质量。 3.通过对教职员工进行分子遗传学方面的专门培训，继续提供可用于分析人类基因组的分子遗传学新方法。 4.开发一种系统，用于对来自人类和其他来源的核酸进行基因分型和/或DNA测序。