ACTIVITY 2: ENHANCEMENT OF INSTITUTIONAL RESEARCH CAPACITY IN MOLECULAR GENETICS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。由于它们密切的相互作用和互补的基础设施，我们建议将分子生物学核心设施和先前在波多黎各大学医学院校园建立的人类分子遗传学单位（uprr - msc）融合为一个单一的核心设施，称为分子遗传学核心设施（MGCF）。该设施的目标是通过支持具有强大分子生物学和分子遗传学成分的基础和临床导向项目来增强我们的机构生物医学研究能力。为实现这一目标，我们提出以下具体目标。1. 提供必要的基础设施，以维持目前在MSC进行的分子遗传学研究，特别是那些解决健康差距的项目。2. 通过培养研究生和本科生在分子生物学和遗传学领域的研究项目，增加理学硕士项目的临界质量。3. 通过为教职员工提供分子遗传学的专业培训，继续提供分子遗传学的新方法，可用于分析人类基因组。4. 开发人类和其他来源的核酸基因分型和/或DNA测序系统。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Because of their close interaction and complementing infrastructures, we proposed that the Molecular Biology Core Facility and the Human Molecular Genetics Unit previously established at the University of Puerto Rico Medical Sciences Campus (UPR-MSC) be fused into a single core facility called the Molecular Genetics Core Facility (MGCF). The goal of this facility was to enhance our institutional biomedical research capability by supporting basic and clinically oriented projects with strong molecular biology and molecular genetics components. To fulfill this goal, we proposed the following specific aims. 1. To provide the infrastructure necessary to sustain the research currently conducted in molecular genetics at the MSC especially those projects that address health disparities. 2. To increase the critical mass of research projects in molecular biology and genetics conducted at the MSC by training graduate and undergraduate students in these areas. 3. To continue to make available new methodologies in molecular genetics that can be used for analysis of the human genome by providing specialized training in molecular genetics to faculty and staff members. 4. To develop a system for genotyping and/or DNA sequencing of nucleic acids derived from humans and other sources.