ACTIVITY #2 - CENTER FOR MOLECULAR GENETICS AND INFECTIOUS DISEASES RESEARCH

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 研究中心，而研究中心不一定是研究者所在的机构。 分子遗传学和传染病研究中心的长期目标是发展和加强合作研究环境，使波多黎各大学医学科学校区的分子遗传学和传染病的高质量生物医学研究成为可能。该中心将由三个部分组成：人类遗传学、传染病和分子生物学，并有相应的协调员作为一个团队共同工作。通过拟议的中心，我们将开发应用高通量基因分型技术的专业知识，我们将培训工作人员在与建立和保存用于研究目的的人类组织样本永生化细胞系相关的技术，并将其提供给MSC的研究界。 我们建议保持手头上，并应用新的DNA和RNA分离方法，以不同的生物体和生物样品的核酸序列分析一般。我们建议通过追求拟议的分子遗传学和传染病研究中心的以下具体目标来实现这些目标：1。加强MSC基础科学家和临床医生之间的科学互动，并加强与分子生物学，人类遗传学和传染病领域的国际科学家的合作; 2。提供培训，教育和支持青年科学家以及基础和临床研究人员的发展，通过提供由该领域国际公认的领导人讲授的定期培训，研讨会和讲习班; 3.鼓励新的科学家，临床和基础，成为积极从事分子生物学，人类遗传学和传染病的研究; 4。建立一个集中的DNA、血浆和细胞库设施，储存用于分子遗传学研究目的的人类血液或皮肤活检的临床样本; 5.提供分子生物学、人类遗传学和传染病方面的基本核心实验室服务，包括技术支持、咨询和培训;与“研究中的信息架构中心”合作，启动专门领域培训课程的网播。我们将把这些举措的重点放在外部资助的，跨学科的，合作项目，这将提高生物医学和临床研究的质量与健康的差距在波多黎各和全国，在医学科学校园。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The long term goal of the Center for Molecular Genetics and Infectious Diseases Research is to develop and strengthen a collaborative research environment that will enable high quality biomedical research in molecular genetics and infectious diseases at the University of Puerto Rico Medical Sciences Campus. The Center will consist of three components: Human Genetics, Infectious Disease and Molecular Biology, with corresponding coordinators working together as a team. Through the proposed Center we will develop the expertise to apply high throughput genotyping technologies, we will train staff in the technology related to the establishment and preservation of immortalized cell lines from human tissue samples for the purpose of research, and make these available to the research community at the MSC. We propose to maintain on-hand and apply novel DNA and RNA isolation methodologies to a diverse group of organisms and biological samples for nucleic acids sequence analysis in general. We propose to accomplish these goals by pursuing the following specific aims of the proposed Center for Molecular Genetics and Infectious Diseases Research: 1. To strengthen the scientific interactions between basic scientists and clinicians from the MSC and to enhance collaborations with international scientists working in molecular biology, human genetics, and infectious diseases; 2. To provide training, education, and support for the development of young scientists as well as established basic and clinical researchers, by offering regular trainings, seminars, and workshops imparted by internationally recognized leaders in the field; 3. To stimulate new scientists, both clinical and basic, to become actively engaged in molecular biology, human genetics, and infectious diseases research; 4. Establish a centralized DNA, plasma and cell banking facility for storage of clinical samples from human blood or skin biopsies for research purposes in molecular genetics; 5. To provide basic core laboratory services in molecular biology, human genetics, and infectious diseases including technical support, consulting, and training; 6. To initiate webcasting of training sessions in specialized areas in collaboration with the "Center for Information Architecture in Research". We will focus these initiatives on externally funded, interdisciplinary, collaborative projects that will enhance the quality of biomedical and clinical research linked to health disparities in Puerto Rico and nationally, at the Medical Sciences Campus.