Diapause in Culex Mosquitoes

库蚊滞育

基本信息

  • 批准号:
    8466274
  • 负责人:
  • 金额:
    $ 56.12万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2009
  • 资助国家:
    美国
  • 起止时间:
    2009-06-01 至 2015-05-31
  • 项目状态:
    已结题

项目摘要

Project Summary Mosquito-borne diseases represent major health problems in most developing countries and have emerged as significant threats for epidemic outbreaks in developed countries. Exacerbating these problems are the emergence of insecticide resistance in mosquito populations, drug resistance among parasite populations, delayed progress in vaccine development, lack of support for mosquito control programs, and increased global travel. Mosquitoes in the Culex pipiens complex are primary vectors for the lymphatic filarioid nematode parasite, Wuchereria bancrofti and several arboviruses. This includes the recently introduced West Nile virus in North America. The long- term objectives of the proposed research are to identify, isolate and characterize genetic factors associated with diapause, a trait that strongly impacts the geographic distribution and survival of species within the Culex pipiens complex. At present, no knowledge exists on the molecular determinants of diapause in Culex. The objectives of this proposal are based on the general hypothesis that genes associated with the diapause phenotype can be identified and isolated by positional cloning techniques. Identification of genes determining diapause and the knowledge from the detailed understanding of the associated biochemical pathways could have several potential applications including: transgene constructs that promote altered and disease limiting behaviors following population replacement, development of targeted biopesticides, or identification of biologically relevant antagonists that disrupt behaviors critical to pathogen transmission or survival. The specific aims of the project are to: 1) fine-scale map genome regions identified as containing genes that determine the diapause phenotype, 2) identify candidate genes determining diapause, and 3) conduct functional analysis of candidate genes determining diapause. Information from genetic crosses will be leveraged against the Cx. quinquefasciatus genome project to identify candidate genes within discrete genome regions. Candidate genes will be evaluated using microarrays, followed by quantitative real time PCR assays to confirm and expand microarray results for promising genes. Positive candidate genes will be assayed for biological relevance using RNA interference mediated gene knockdowns or gene overexpression using recombinant Sindbis transducing viruses. Results from laboratory experiments will then be evaluated among natural populations representing Cx. pipiens s.s. and Cx. quinquefasciatus.
项目总结

项目成果

期刊论文数量(7)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Whole transcriptome responses among females of the filariasis and arbovirus vector mosquito Culex pipiens implicate TGF-β signaling and chromatin modification as key drivers of diapause induction.
  • DOI:
    10.1007/s10142-015-0432-5
  • 发表时间:
    2015-07
  • 期刊:
  • 影响因子:
    2.9
  • 作者:
    Hickner, Paul V.;Mori, Akio;Zeng, Erliang;Tan, John C.;Severson, David W.
  • 通讯作者:
    Severson, David W.
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DAVID W SEVERSON其他文献

DAVID W SEVERSON的其他文献

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{{ truncateString('DAVID W SEVERSON', 18)}}的其他基金

Autogeny in Aedes aegypti
埃及伊蚊的自体繁殖
  • 批准号:
    7878958
  • 财政年份:
    2010
  • 资助金额:
    $ 56.12万
  • 项目类别:
Autogeny in Aedes aegypti
埃及伊蚊的自体繁殖
  • 批准号:
    8020955
  • 财政年份:
    2010
  • 资助金额:
    $ 56.12万
  • 项目类别:
Midgut Bacteria in Aedes aegypti and Vector Competence
埃及伊蚊的中肠细菌和媒介能力
  • 批准号:
    8071145
  • 财政年份:
    2009
  • 资助金额:
    $ 56.12万
  • 项目类别:
Midgut Bacteria in Aedes aegypti and Vector Competence
埃及伊蚊的中肠细菌和媒介能力
  • 批准号:
    7821310
  • 财政年份:
    2009
  • 资助金额:
    $ 56.12万
  • 项目类别:
Diapause in Culex Mosquitoes
库蚊滞育
  • 批准号:
    8076324
  • 财政年份:
    2009
  • 资助金额:
    $ 56.12万
  • 项目类别:
Diapause in Culex Mosquitoes
库蚊滞育
  • 批准号:
    8278677
  • 财政年份:
    2009
  • 资助金额:
    $ 56.12万
  • 项目类别:
Diapause in Culex Mosquitoes
库蚊滞育
  • 批准号:
    7653901
  • 财政年份:
    2009
  • 资助金额:
    $ 56.12万
  • 项目类别:
Midgut Bacteria in Aedes aegypti and Vector Competence
埃及伊蚊的中肠细菌和媒介能力
  • 批准号:
    7627063
  • 财政年份:
    2009
  • 资助金额:
    $ 56.12万
  • 项目类别:
Diapause in Culex Mosquitoes
库蚊滞育
  • 批准号:
    7807124
  • 财政年份:
    2009
  • 资助金额:
    $ 56.12万
  • 项目类别:
Molecular Genetics of Dengue Resistance in Mosquitoes
蚊子抗登革热的分子遗传学
  • 批准号:
    7070021
  • 财政年份:
    2004
  • 资助金额:
    $ 56.12万
  • 项目类别:

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