Web-based CBT for Opioid-treated, Chronic Pain Patients with Aberrant Behavior

针对接受阿片类药物治疗、行为异常的慢性疼痛患者的基于网络的 CBT

基本信息

项目摘要

DESCRIPTION (provided by applicant): Although opioid therapy has gained increasing acceptance as a treatment for patients with chronic non-malignant pain (CNMP), concerns persist related to achievement of treatment goals (reduction in pain severity and pain interference) and medication misuse/abuse within the clinical context (often described as aberrant drug related behavior). Psychosocial approaches (particularly self-management strategies such as cognitive-behavior therapy [CBT]) have been found to be efficacious for the treatment of CNMP. However, most chronic pain patients are not exposed to comprehensive psychosocial interventions, largely due to the lack of expertise and time among physicians who prescribe opioids. To address this public health concern, we propose to develop, implement, and evaluate an innovative CBT intervention for the treatment of chronic pain tailored to the specific needs of patients who are being prescribed opioids and who present with aberrant behaviors. To our knowledge, the planned program will be the first interactive, web- based program to provide comprehensive, psychosocial treatment to this population. The specific aims are: Aim 1: Develop an interactive, computer-delivered psychosocial treatment for chronic pain patients with aberrant drug-related behavior. We will modify the content of our previously developed and evaluated Therapeutic Education System (TES), a web-based computer-delivered therapy program for individuals with substance use disorders of demonstrated efficacy, to be appropriate for a population of chronic pain patients. The planned TES program will consist of 24 modules and will be theoretically grounded in the cognitive- behavioral perspective, incorporating a set of techniques that have been shown to be effective for chronic pain patients with adaptations from the substance abuse literature. Through an iterative development process with both expert consultants and chronic pain patients, we will determine how to best present the information in the program and assess each module's acceptability, ease of use, likeability, helpfulness, and relevance to the experience of chronic pain patients. AIM 2: Evaluate the efficacy of the computer-delivered intervention with chronic pain patients with aberrant drug-related behavior in outpatient treatment for chronic pain. Chronic pain patients will be randomized to receive either: (1) treatment as usual (TAU; n=55); or (2) TAU plus the computer-delivered psychosocial intervention (n=55). Primary outcomes are pain severity, pain interference behaviors, and drug-related aberrant behavior; secondary outcomes include substance misuse, other pain behaviors, and physical and emotional functioning. AIM 3: Examine two therapeutic mechanisms hypothesized to mediate the relationship between the CBT TES intervention and behavioral outcomes: (1) cognitive distortions (e.g., helplessness) relevant to effective pain management and coping and; (2) expectations about the future. This proposed web-based intervention has the potential to markedly improve the treatment of chronic pain by enabling widespread access to evidence-based CBT for chronic pain. Abstract for Web-based CBT for pain grant-FINAL.doc
描述(由申请方提供):尽管阿片类药物治疗作为慢性非恶性疼痛(CNMP)患者的治疗方法已获得越来越多的认可,但与实现治疗目标(减轻疼痛严重程度和疼痛干扰)和临床背景下的药物误用/滥用(通常描述为异常药物相关行为)相关的问题仍然存在。心理社会方法(特别是自我管理策略,如认知行为疗法[CBT])已被发现是有效的治疗CNMP。然而,大多数慢性疼痛患者没有接受全面的心理社会干预,这主要是由于处方阿片类药物的医生缺乏专业知识和时间。为了解决这一公共卫生问题,我们建议开发,实施和评估一种创新的CBT干预措施,用于治疗慢性疼痛,以满足正在服用阿片类药物和存在异常行为的患者的特定需求。据我们所知,计划中的项目将是第一个互动的,基于网络的项目,为这一人群提供全面的,心理社会治疗。具体目标是:目标1:开发一种交互式的,计算机提供的心理治疗慢性疼痛患者与异常药物相关的行为。我们将修改我们以前开发和评估的治疗教育系统(TES)的内容,这是一个基于网络的计算机提供的治疗计划,适用于具有已证明疗效的物质使用障碍的个人,以适应慢性疼痛患者的人群。计划中的TES计划将包括24个模块,并将在理论上立足于认知行为的角度,纳入一套技术,已被证明是有效的慢性疼痛患者与适应物质滥用文献。通过与专家顾问和慢性疼痛患者的迭代开发过程,我们将确定如何最好地呈现程序中的信息,并评估每个模块的可接受性,易用性,可爱性,有用性以及与慢性疼痛患者体验的相关性。目标2:评价计算机传递干预对门诊治疗慢性疼痛中药物相关行为异常的慢性疼痛患者的疗效。慢性疼痛患者将随机接受:(1)常规治疗(TAU; n=55);或(2)TAU加计算机提供的心理社会干预(n=55)。主要结果是疼痛严重程度,疼痛干扰行为和药物相关的异常行为;次要结果包括物质滥用,其他疼痛行为以及身体和情绪功能。目标3:检查假设调解CBT TES干预和行为结果之间关系的两种治疗机制:(1)认知扭曲(例如,无助)相关的有效疼痛管理和应对;(2)对未来的期望。这项基于网络的干预措施有可能通过广泛获得慢性疼痛的循证CBT来显着改善慢性疼痛的治疗。基于Web的CBT疼痛补助金摘要-FINAL.doc

项目成果

期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Patient vs provider reports of aberrant medication-taking behavior among opioid-treated patients with chronic pain who report misusing opioid medication.
  • DOI:
    10.1097/j.pain.0000000000000583
  • 发表时间:
    2016-08
  • 期刊:
  • 影响因子:
    7.4
  • 作者:
    Nikulina V;Guarino H;Acosta MC;Marsch LA;Syckes C;Moore SK;Portenoy RK;Cruciani RA;Turk DC;Rosenblum A
  • 通讯作者:
    Rosenblum A
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Lisa A. Marsch其他文献

Barreras de acceso, autoreconocimiento y reconocimiento en depresión y trastornos del consumo del alcohol: un estudio cualitativo
  • DOI:
    10.1016/j.rcp.2020.11.021
  • 发表时间:
    2021-06-01
  • 期刊:
  • 影响因子:
  • 作者:
    Carlos Gómez-Restrepo;Paula Cárdenas;Arturo Marroquín-Rivera;Magda Cepeda;Fernando Suárez-Obando;José Miguel Uribe-Restrepo;Sergio Castro;Leonardo Cubillos;William C. Torrey;Sophia M. Bartels;Catherine Van Arcken-Martínez;Sena Park;Deepak John;Lisa A. Marsch
  • 通讯作者:
    Lisa A. Marsch
Is telemedicine the answer to rural expansion of medication treatment for opioid use disorder? Early experiences in the feasibility study phase of a National Drug Abuse Treatment Clinical Trials Network Trial
  • DOI:
    10.1186/s13722-021-00233-x
  • 发表时间:
    2021-04-20
  • 期刊:
  • 影响因子:
    3.200
  • 作者:
    Yih-Ing Hser;Allison J. Ober;Alex R. Dopp;Chunqing Lin;Katie P. Osterhage;Sarah E. Clingan;Larissa J. Mooney;Megan E. Curtis;Lisa A. Marsch;Bethany McLeman;Emily Hichborn;Laurie S. Lester;Laura-Mae Baldwin;Yanping Liu;Petra Jacobs;Andrew J. Saxon
  • 通讯作者:
    Andrew J. Saxon
Relación entre las características sociodemográficas de los participantes del proyecto DIADA y la tasa de cumplimiento al seguimiento en la fase inicial de la intervención
  • DOI:
    10.1016/j.rcp.2020.11.019
  • 发表时间:
    2021-06-01
  • 期刊:
  • 影响因子:
  • 作者:
    María Paula Cárdenas Charry;Maria Paula Jassir Acosta;José Miguel Uribe Restrepo;Magda Cepeda;Pablo Martínez Camblor;Leonardo Cubillos;Sophia M. Bartels;Sergio Castro;Lisa A. Marsch;Carlos Gómez-Restrepo
  • 通讯作者:
    Carlos Gómez-Restrepo
Comparative efficacy of a computer-based HIV testing video intervention in sites of varying HIV prevalence
  • DOI:
    10.1016/j.drugalcdep.2014.09.040
  • 发表时间:
    2015-01-01
  • 期刊:
  • 影响因子:
  • 作者:
    Ian D. Aronson;Sonali Rajan;Lisa A. Marsch;Juline Koken;Theodore Bania
  • 通讯作者:
    Theodore Bania
Caracterización de los usuarios de las redes sociales dentro del sistema de atención primaria en Colombia y predictores de su uso de las redes sociales para comprender su salud
  • DOI:
    10.1016/j.rcp.2020.12.010
  • 发表时间:
    2021-06-01
  • 期刊:
  • 影响因子:
  • 作者:
    Sophia M. Bartels;Pablo Martinez-Camblor;John A. Naslund;Fernando Suárez-Obando;William C. Torrey;Leonardo Cubillos;Makeda J. Williams;Sergio M. Castro;José M. Uribe-Restrepo;Carlos Gómez-Restrepo;Lisa A. Marsch
  • 通讯作者:
    Lisa A. Marsch

Lisa A. Marsch的其他文献

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{{ truncateString('Lisa A. Marsch', 18)}}的其他基金

Pilot Project Core
试点项目核心
  • 批准号:
    10624456
  • 财政年份:
    2021
  • 资助金额:
    $ 48.34万
  • 项目类别:
Pilot Project Core
试点项目核心
  • 批准号:
    10268739
  • 财政年份:
    2021
  • 资助金额:
    $ 48.34万
  • 项目类别:
Technology-based Treatments for Substance Use Disorders
基于技术的药物使用障碍治疗
  • 批准号:
    10268734
  • 财政年份:
    2021
  • 资助金额:
    $ 48.34万
  • 项目类别:
Emerging Technologies & Data Analytics Core
新兴技术
  • 批准号:
    10469415
  • 财政年份:
    2021
  • 资助金额:
    $ 48.34万
  • 项目类别:
Pilot Project Core
试点项目核心
  • 批准号:
    10469416
  • 财政年份:
    2021
  • 资助金额:
    $ 48.34万
  • 项目类别:
Treatment Development & Evaluation Core
治疗开发
  • 批准号:
    10624448
  • 财政年份:
    2021
  • 资助金额:
    $ 48.34万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    10624445
  • 财政年份:
    2021
  • 资助金额:
    $ 48.34万
  • 项目类别:
Dissemination & Implementation Core
传播
  • 批准号:
    10268737
  • 财政年份:
    2021
  • 资助金额:
    $ 48.34万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    10469412
  • 财政年份:
    2021
  • 资助金额:
    $ 48.34万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    10268735
  • 财政年份:
    2021
  • 资助金额:
    $ 48.34万
  • 项目类别:

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