Moderating Influence of Ovarian Hormones on Physiological Arousal and Headache

卵巢激素对生理唤醒和头痛的调节影响

• 批准号: 8470255
• 负责人: TIMOTHY T HOULE
• 金额: $ 30.46万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-15 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8470255
• 关键词: American; Arousal; Bed rest; Behavior Therapy; Behavioral; Buffers; Data; Disabled Persons; Early Intervention; Estradiol; Exhibits; Female; Glean; Goals; Headache; Heart Rate; Hormonal; Hormones; Impairment; Knowledge; Lead; Measures; Mediating; Menstrual cycle; Migraine; Moods; Nature; Observational Study; Ovarian; Ovarian hormone; Patients; Pharmacological Treatment; Physiological; Precipitating Factors; Process; Productivity; Progesterone; Psychophysiology; Reporting; Research; Role; Stress; Symptoms; Theoretical model; Time; United States; Women' s Group; base; cost; functional disability; heart rate variability; population based; success

Project Summary Headache symptoms for a given patient may vary widely from one day to the next, ranging from days when the migraine sufferer is asymptomatic to days when he or she is functionally disabled with severe headache. Increased knowledge of the factors that precipitate migraine ("migraine triggers") will lead to an enhanced ability to accurately predict migraine attacks. This knowledge will be very beneficial for planning pharmacological and behavioral management strategies, many of which are optimally applied either before an attack begins or early in a new attack. Our current understanding of migraine precipitants is almost entirely based on single precipitants studied using cross-sectional, population-based examinations. The effect that multiple precipitants may have on initiating migraine, or the role of hormones in moderating the influence of any single precipitant is unclear. The proposed research is an observational study that utilizes the natural variability of ovarian hormones to examine the relationship between physiological arousal (e.g., heart rate, breath rate, perceived stress), ovarian hormones, and migraine activity in a group of women who are sensitive to hormonal influences (i.e., they have menstrually related migraine). The specific hypothesis behind the proposed research is that migraine activity can be independently predicted by psychophysiological arousal and that this relationship is moderated by hormonal influences. The data from the study will be used to inform a theoretical model that will greatly enhance our understanding of the interplay of this dynamic process. The specific aims are: Aim 1: To examine the relationships between several measures of psychophysiological arousal and headache activity. Aim 2: To examine the relationship between ovarian hormone levels and headache activity. Aim 3: To examine the mediating role of physiological arousal on the relationship between stress and migraine in the context of a potential moderating role of ovarian hormones on these relationships.

项目摘要 给定患者的头痛症状可能从一天到另一天不等，范围从天数 当偏头痛患者无症状与严重功能残疾的日子无症状时 头痛。对导致偏头痛的因素的了解增加（“偏头痛触发”）将导致 增强了准确预测偏头痛攻击的能力。这些知识将对计划非常有益 药理学和行为管理策略，其中许多是最佳应用的 攻击是在新攻击中开始或早期的。我们目前对偏头痛降水剂的理解几乎完全是 基于使用横截面，基于人群的检查进行研究的单一沉淀物。效果 多种沉淀物可能在启动偏头痛方面具有 单个沉淀剂尚不清楚。 拟议的研究是一项观察性研究，利用卵巢激素的自然变异性 检查生理唤醒之间的关系（例如，心率，呼吸率，感知的压力）， 一群对激素影响敏感的妇女中的卵巢激素和偏头痛活动（即 他们具有月经相关的偏头痛）。拟议研究背后的具体假设是 偏头痛活动可以通过心理生理唤醒独立预测，这种关系是 受荷尔蒙影响调节。研究的数据将用于告知理论模型，该模型将 极大地增强了我们对这个动态过程相互作用的理解。 具体目的是： 目标1：检查心理生理多种措施之间的关系 唤醒和头痛活动。 目标2：检查卵巢激素水平与头痛活动之间的关系。 目的3：检查生理唤醒对之间关系的中介作用 在卵巢激素对潜在调节作用的背景下，压力和偏头痛 这些关系。