Moderating Influence of Ovarian Hormones on Physiological Arousal and Headache

项目摘要 特定患者的头痛症状可能从一天到第二天有很大的不同，从几天到几天不等。 当偏头痛患者没有症状的日子，他或她的功能残疾，严重 头疼。对导致偏头痛的因素(“偏头痛诱因”)的了解增加将导致 增强了准确预测偏头痛发作的能力。这些知识将对规划非常有益。 药理学和行为管理策略，其中许多策略在 攻击开始或在新攻击的早期。我们目前对偏头痛沉淀剂的理解几乎完全是 以单一沉淀物为基础，采用横断面、基于人口的检查方法进行研究。其效果是 多种沉淀剂可能对偏头痛的启动起作用，或激素在缓和任何 单一沉淀物尚不清楚。 这项拟议的研究是一项观察性研究，利用卵巢激素的自然可变性。 为了研究生理唤醒(例如，心率、呼吸频率、感知到的压力)、 对荷尔蒙影响敏感的一组女性的卵巢激素和偏头痛活动(即， 他们有月经相关的偏头痛)。这项拟议研究背后的具体假设是 偏头痛活动可以通过心理生理唤醒独立预测，这种关系是 受荷尔蒙的影响而有所缓和。这项研究的数据将被用来提供一个理论模型，该模型将 极大地加强了我们对这一动态过程的相互作用的理解。 具体目标是： 目的1：检验心理生理学的几种测量之间的关系 觉醒和头痛活动。 目的2：探讨卵巢激素水平与头痛活动的关系。 目的3：考察生理唤醒在不同性别之间关系中的中介作用。 应激和偏头痛背景下卵巢激素的潜在调节作用 这些关系。

Project Summary Headache symptoms for a given patient may vary widely from one day to the next, ranging from days when the migraine sufferer is asymptomatic to days when he or she is functionally disabled with severe headache. Increased knowledge of the factors that precipitate migraine ("migraine triggers") will lead to an enhanced ability to accurately predict migraine attacks. This knowledge will be very beneficial for planning pharmacological and behavioral management strategies, many of which are optimally applied either before an attack begins or early in a new attack. Our current understanding of migraine precipitants is almost entirely based on single precipitants studied using cross-sectional, population-based examinations. The effect that multiple precipitants may have on initiating migraine, or the role of hormones in moderating the influence of any single precipitant is unclear. The proposed research is an observational study that utilizes the natural variability of ovarian hormones to examine the relationship between physiological arousal (e.g., heart rate, breath rate, perceived stress), ovarian hormones, and migraine activity in a group of women who are sensitive to hormonal influences (i.e., they have menstrually related migraine). The specific hypothesis behind the proposed research is that migraine activity can be independently predicted by psychophysiological arousal and that this relationship is moderated by hormonal influences. The data from the study will be used to inform a theoretical model that will greatly enhance our understanding of the interplay of this dynamic process. The specific aims are: Aim 1: To examine the relationships between several measures of psychophysiological arousal and headache activity. Aim 2: To examine the relationship between ovarian hormone levels and headache activity. Aim 3: To examine the mediating role of physiological arousal on the relationship between stress and migraine in the context of a potential moderating role of ovarian hormones on these relationships.