Moderating Influence of Ovarian Hormones on Physiological Arousal and Headache

项目摘要 头痛症状为一个给定的病人可能会有很大的不同，从一天到下一个，从天 当偏头痛患者无症状时， 头痛.增加对诱发偏头痛的因素（“偏头痛触发因素”）的了解将导致 提高准确预测偏头痛发作的能力。这些知识将对规划非常有益 药理学和行为管理策略，其中许多是最佳应用之前， 在新的攻击开始或早期。我们目前对偏头痛促发剂的了解几乎完全是 基于单一沉淀物研究使用横截面，人口为基础的考试。大意是 多种沉淀剂可能对偏头痛的起始有影响，或者激素在缓和任何沉淀剂的影响中的作用。 单一沉淀剂尚不清楚。 这项拟议中的研究是一项观察性研究，利用卵巢激素的自然变异性 为了检查生理唤醒（例如，心率、呼吸率、感知压力）， 卵巢激素和偏头痛活动在一组对激素影响敏感的妇女中（即， 他们患有与头痛有关的偏头痛）。拟议研究背后的具体假设是， 偏头痛活动可以通过心理生理唤醒独立预测， 受到荷尔蒙的影响该研究的数据将用于为理论模型提供信息， 大大加强了我们对这一动态过程相互作用的理解。 具体目标是： 目的1：研究心理生理学的几种测量方法之间的关系 兴奋和头痛活动。 目的2：探讨卵巢激素水平与头痛活动的关系。 目的3：探讨生理唤醒在认知功能与认知功能关系中的中介作用。 压力和偏头痛的背景下，卵巢激素的潜在调节作用， 这些关系。

Project Summary Headache symptoms for a given patient may vary widely from one day to the next, ranging from days when the migraine sufferer is asymptomatic to days when he or she is functionally disabled with severe headache. Increased knowledge of the factors that precipitate migraine ("migraine triggers") will lead to an enhanced ability to accurately predict migraine attacks. This knowledge will be very beneficial for planning pharmacological and behavioral management strategies, many of which are optimally applied either before an attack begins or early in a new attack. Our current understanding of migraine precipitants is almost entirely based on single precipitants studied using cross-sectional, population-based examinations. The effect that multiple precipitants may have on initiating migraine, or the role of hormones in moderating the influence of any single precipitant is unclear. The proposed research is an observational study that utilizes the natural variability of ovarian hormones to examine the relationship between physiological arousal (e.g., heart rate, breath rate, perceived stress), ovarian hormones, and migraine activity in a group of women who are sensitive to hormonal influences (i.e., they have menstrually related migraine). The specific hypothesis behind the proposed research is that migraine activity can be independently predicted by psychophysiological arousal and that this relationship is moderated by hormonal influences. The data from the study will be used to inform a theoretical model that will greatly enhance our understanding of the interplay of this dynamic process. The specific aims are: Aim 1: To examine the relationships between several measures of psychophysiological arousal and headache activity. Aim 2: To examine the relationship between ovarian hormone levels and headache activity. Aim 3: To examine the mediating role of physiological arousal on the relationship between stress and migraine in the context of a potential moderating role of ovarian hormones on these relationships.