Moderating Influence of Ovarian Hormones on Physiological Arousal and Headache

卵巢激素对生理唤醒和头痛的调节影响

• 批准号: 7635564
• 负责人: TIMOTHY T HOULE
• 金额: $ 30.91万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-15 至 2014-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7635564
• 关键词: American; Arousal; Bed rest; Behavior Therapy; Behavioral; Buffers; Data; Disabled Persons; Early treatment; Estradiol; Exhibits; Female; Glean; Goals; Headache; Heart Rate; Hormonal; Hormones; Impairment; Knowledge; Lead; Measures; Mediating; Menstrual cycle; Migraine; Moods; Nature; Observational Study; Ovarian; Ovarian hormone; Patients; Physiological; Precipitating Factors; Process; Productivity; Progesterone; Psychophysiology; Reporting; Research; Role; Stress; Symptoms; Theoretical model; Time; United States; Women' s Group; base; cost; functional disability; heart rate variability; population based; public health relevance; success

DESCRIPTION (provided by applicant): Headache symptoms for a given patient may vary widely from one day to the next, ranging from days when the migraine sufferer is asymptomatic to days when he or she is functionally disabled with severe headache. Increased knowledge of the factors that precipitate migraine ("migraine triggers") will lead to an enhanced ability to accurately predict migraine attacks. This knowledge will be very beneficial for planning pharmacological and behavioral management strategies, many of which are optimally applied either before an attack begins or early in a new attack. Our current understanding of migraine precipitants is almost entirely based on single precipitants studied using cross-sectional, population-based examinations. The effect that multiple precipitants may have on initiating migraine, or the role of hormones in moderating the influence of any single precipitant is unclear. The proposed research is an observational study that utilizes the natural variability of ovarian hormones to examine the relationship between physiological arousal (e.g., heart rate, breath rate, perceived stress), ovarian hormones, and migraine activity in a group of women who are sensitive to hormonal influences (i.e., they have menstrually related migraine). The specific hypothesis behind the proposed research is that migraine activity can be independently predicted by psychophysiological arousal and that this relationship is moderated by hormonal influences. The data from the study will be used to inform a theoretical model that will greatly enhance our understanding of the interplay of this dynamic process. The specific aims are: Aim 1: To examine the relationships between several measures of psychophysiological arousal and headache activity. Aim 2: To examine the relationship between ovarian hormone levels and headache activity. Aim 3: To examine the mediating role of physiological arousal on the relationship between stress and migraine in the context of a potential moderating role of ovarian hormones on these relationships. PUBLIC HEALTH RELEVANCE: According to a recent study, 90% of migraineurs reported functional impairment with their headaches and 53% exhibited severe impairment requiring bed rest. In the United States, migraine results in 112 million bedridden days each year with the cost of migraine to the total American workforce estimated at $13 billion a year in missed workdays and lost productivity. The goal of the present research is to make migraine attacks more predictable by increasing knowledge of headache precipitants thus decreasing the burden of migraine by allowing for earlier intervention during a migraine attack.

描述（由申请人提供）：给定患者的头痛症状可能从一天到下一天变化很大，范围从偏头痛患者无症状的日子到他或她因严重头痛而功能障碍的日子。增加对诱发偏头痛的因素（“偏头痛触发因素”）的了解将导致准确预测偏头痛发作的能力增强。这些知识将非常有益于规划药理学和行为管理策略，其中许多策略在发作开始前或新发作早期得到最佳应用。我们目前对偏头痛促发剂的理解几乎完全基于使用横断面，基于人群的检查研究的单一促发剂。多种沉淀剂对偏头痛的影响，或激素在调节任何单一沉淀剂的影响中的作用尚不清楚。这项拟议的研究是一项观察性研究，利用卵巢激素的自然变异来检查生理唤醒（例如，心率、呼吸率、感知压力）、卵巢激素和对激素影响敏感的女性群体的偏头痛活动（即，他们患有与头痛有关的偏头痛）。这项研究背后的具体假设是，偏头痛活动可以通过心理生理唤醒独立预测，并且这种关系受到激素影响的调节。该研究的数据将用于为理论模型提供信息，这将大大增强我们对这一动态过程相互作用的理解。具体目标是：目的1：研究心理生理唤醒和头痛活动的几个措施之间的关系。目的2：探讨卵巢激素水平与头痛活动的关系。目标三：在卵巢激素对这些关系的潜在调节作用的背景下，研究生理唤醒对压力和偏头痛之间关系的中介作用。公共卫生相关性：根据最近的一项研究，90%的偏头痛患者报告了头痛的功能障碍，53%的患者表现出需要卧床休息的严重障碍。在美国，偏头痛每年导致1.12亿个卧床不起的日子，偏头痛给美国劳动力造成的损失估计为每年130亿美元，包括错过工作日和生产力损失。本研究的目的是通过增加头痛促发剂的知识使偏头痛发作更可预测，从而通过允许在偏头痛发作期间进行早期干预来减轻偏头痛的负担。