MIGRAINE FORECAST

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 本研究的主要目的是初步探讨几种头痛促进剂对偏头痛患者的预测效用。这项研究背后的具体假设是，偏头痛活动可以通过一种独特的心理生理学预测因子组合来准确预测。从这样的患者内检查中收集的信息是患者特异性的，将大大提高我们对偏头痛促发剂的性质及其与头痛活动的关系的理解。这种增强的理解将允许药物（曲坦类）和行为治疗的早期干预，这是治疗成功的关键。此外，增强偏头痛活动的预测将有助于跨学科研究，也许最值得注意的是成像研究。有几个具体目标是有针对性的，如下所列： 具体目标1：检查/证明研究的可行性？？的两个月的数据收集工作，并获得估计的预期程度的缺失数据所造成的协议。 具体目标二：估计随着时间的推移，一个人体内几种偏头痛触发因素的效应大小（效力），包括它们的相互作用;用于统计功效计算，用于更大的数据收集工作。 具体目标3：初步估计偏头痛触发因素和偏头痛活动之间观察到的个体内关系的个体差异

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The main study objectives are to preliminarily examine the predictive utility of several headache precipitants within individual migraine sufferers over time. The specific hypothesis behind the proposed research is that migraine activity can be accurately predicted by a unique combination of psychophysiological predictors. Information gleaned from such a within-patient examination is patient-specific and will greatly enhance our understanding of the nature of migraine precipitants and their relationship to headache activity. This enhanced understanding will allow for earlier intervention of pharmacological (triptans) and behavioral treatments which are crucial to treatment success. Further, enhanced prediction of migraine activity will aid in cross-disciplinary research, perhaps most notably for imaging studies. Several specific aims are targeted and listed below: Specific Aim 1: To examine/demonstrate the feasibility of the study¿??s two-month data collection efforts and to obtain estimates of the expected degree of missing data resulting from the protocol. Specific Aim 2: To estimate the effect sizes (potency of) of several migraine triggers within a person over time, including their interactions; to be used for statistical power calculations to be used in a larger data collection effort. Specific Aim 3: To obtain preliminary estimates of individual variation of the observed within-person relationships between the migraine triggers and migraine activity