MIGRAINE FORECAST

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The main study objectives are to preliminarily examine the predictive utility of several headache precipitants within individual migraine sufferers over time. The specific hypothesis behind the proposed research is that migraine activity can be accurately predicted by a unique combination of psychophysiological predictors. Information gleaned from such a within-patient examination is patient-specific and will greatly enhance our understanding of the nature of migraine precipitants and their relationship to headache activity. This enhanced understanding will allow for earlier intervention of pharmacological (triptans) and behavioral treatments which are crucial to treatment success. Further, enhanced prediction of migraine activity will aid in cross-disciplinary research, perhaps most notably for imaging studies. Several specific aims are targeted and listed below: Specific Aim 1: To examine/demonstrate the feasibility of the study¿??s two-month data collection efforts and to obtain estimates of the expected degree of missing data resulting from the protocol. Specific Aim 2: To estimate the effect sizes (potency of) of several migraine triggers within a person over time, including their interactions; to be used for statistical power calculations to be used in a larger data collection effort. Specific Aim 3: To obtain preliminary estimates of individual variation of the observed within-person relationships between the migraine triggers and migraine activity