MIGRAINE FORECAST

偏头痛预测

• 批准号: 7607713
• 负责人: TIMOTHY T HOULE
• 金额: $ 0.97万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607713
• 关键词: Behavior Therapy; Computer Retrieval of Information on Scientific Projects Database; Data; Data Collection; Early Intervention; Funding; Glean; Grant; Headache; Image; Individual; Institution; Migraine; Nature; Patients; Persons; Protocols documentation; Psychophysiology; Research; Research Personnel; Resources; Source; Time; United States National Institutes of Health; Variant; size; success

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The main study objectives are to preliminarily examine the predictive utility of several headache precipitants within individual migraine sufferers over time. The specific hypothesis behind the proposed research is that migraine activity can be accurately predicted by a unique combination of psychophysiological predictors. Information gleaned from such a within-patient examination is patient-specific and will greatly enhance our understanding of the nature of migraine precipitants and their relationship to headache activity. This enhanced understanding will allow for earlier intervention of pharmacological (triptans) and behavioral treatments which are crucial to treatment success. Further, enhanced prediction of migraine activity will aid in cross-disciplinary research, perhaps most notably for imaging studies. Several specific aims are targeted and listed below: Specific Aim 1: To examine/demonstrate the feasibility of the study¿??s two-month data collection efforts and to obtain estimates of the expected degree of missing data resulting from the protocol. Specific Aim 2: To estimate the effect sizes (potency of) of several migraine triggers within a person over time, including their interactions; to be used for statistical power calculations to be used in a larger data collection effort. Specific Aim 3: To obtain preliminary estimates of individual variation of the observed within-person relationships between the migraine triggers and migraine activity

该副本是使用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这是调查员的机构。 主要的研究目标是初步检查单个偏头痛患者在随着时间的流逝中的几个标头降水剂的预测效用。拟议的研究背后的具体假设是，可以通过心理生理预测因子的独特组合来准确预测偏头痛活性。从这样的患者检查中收集的信息是特定于患者的，它将大大增强我们对偏头痛降水剂性质及其与标头活动的关系的理解。这种增强的理解将允许早期干预药物（triptans）和行为治疗，这对于治疗成功至关重要。此外，增强对偏头痛活性的预测将有助于跨学科研究，这可能是对成像研究的尤为重要。以下几个特定目标是针对和列出的： 具体目的1：检查/证明研究的可行性为两个月的数据收集工作，并获得对协议产生的预期数据的预期程度的估计。 特定目的2：估计一个人内部几个偏头痛触发器的效果大小（效力）随着时间的流逝，包括它们的相互作用；用于用于更大的数据收集工作中的统计功率计算。 特定目的3：获得对偏头痛触发与偏头痛活动之间观察到的人际关系的个体变异的初步估计