Psychotherapy Development Research Center

心理治疗发展研究中心

• 批准号: 8494006
• 负责人: KATHLEEN M. CARROLL
• 金额: $ 183.83万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-07-01 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8494006
• 关键词: Adolescent; Behavior Therapy; Behavioral; Characteristics; Cigarette; Clinical Trials; Cocaine Abuse; Cocaine Dependence; Cognitive Therapy; Communities; Computer Assisted; Computers; Consult; Consultations; Development; Drug abuse; Evaluation; Fostering; Functional Magnetic Resonance Imaging; Funding; Goals; Government; Impulsivity; International; Intervention; Modeling; Neurobiology; Neurocognitive; Pharmaceutical Preparations; Pharmacotherapy; Pilot Projects; Prize; Psychotherapy; Research; Research Personnel; Research Project Grants; Resources; Role; Schools; Site; Smoker; Staging; Testing; Therapeutic Studies; Training; Work; addiction; base; cognitive enhancement; contingency management; efficacy trial; executive function; innovation; neuroimaging; nicotine replacement; programs; psychologic; research and development; substance abuse treatment

DESCRIPTION (provided by applicant): We seek to renew our psychotherapy development research center (PDC) dedicated to the development, evaluation and community application of psychotherapies for drug abuse. The organizing theme is psychotherapy development and empirical testing based on the Stage Model (Rounsaville, Carroll & Onken, 2001) of psychotherapy research. The PDC's goal is to catalyze the development of innovative drug abuse treatments from the point where they are merely "good ideas" to one where they are capable of widespread use as empirically supported treatments (EST's). In years 10-14 of PDC support we have successfully conducted the 4 originally proposed component research projects, completed 11 pilot projects and guided multiple new investigators to develop their first externally supported research projects on behavioral treatments. Key findings include support for efficacy of PDC developed interventions including a computer delivered version of Cognitive Behavioral Therapy (CBT4CBT), a school based Contingency Management (CM) program for adolescent smokers and an adaptively delivered version of Prize Based CM for cocaine abuse. We have also served as a national resource for psychotherapy research by consulting on 50 funded projects outside Yale, participating in 18 multisite behavioral and/or pharmacotherapy efficacy trials, developing computer-assisted training packages to foster more widespread use of efficacious substance abuse treatments and providing consultation on issues related to behavioral therapies research to numerous national and international government organizations and groups. In the past 4 years our research has been increasingly focused on examining the role of impaired executive functioning and impulsivity as fundamental components of addiction and as potential targets for interventions. This work has entailed expanding our neurocognitive assessment battery and incorporating an innovative fMRI neuroimaging paradigm in pilot and component studies. During the renewal period, research will continue to be organized around the Stage Model with a CORE facility and 3 component projects. Core staff will oversee an ambitious pilot study program and provide scientific oversight, administration, standardized psychological and neurobiological assessments, and technical assistance to center projects along with consultation and assistance to investigators and clinicians at other sites. Three late Stage II component clinical trials will examine (1) combining CBT4CBT with a cognitive-enhancement medication, (2) optimal sequences of Prize Based CM for cocaine dependence and (3) combining school based CM with nicotine replacement therapy in a school based cigarette cessation program. CENTER CHARACTERISTICS

描述（由申请人提供）：我们寻求更新我们的心理治疗发展研究中心（PDC），致力于药物滥用心理治疗的开发，评估和社区应用。组织的主题是心理治疗的发展和基于心理治疗研究的阶段模型（Rounsaville，卡罗尔和Onken，2001）的实证检验。PDC的目标是促进创新药物滥用治疗的发展，从仅仅是“好主意”到能够作为经验支持治疗（EST）广泛使用。在PDC的10-14年支持中，我们成功地进行了4个最初提出的组成研究项目，完成了11个试点项目，并指导多个新的研究人员开发了他们的第一个外部支持的行为治疗研究项目。主要研究结果包括支持PDC开发的干预措施，包括计算机交付版本的认知行为疗法（CBT 4CBT），基于学校的应急管理（CM）计划青少年吸烟者和自适应交付版本的基于奖励的CM可卡因滥用的疗效。我们还通过咨询耶鲁大学以外的50个资助项目，参与18个多地点行为和/或药物治疗疗效试验，开发计算机辅助培训包，以促进更广泛地使用有效的药物滥用治疗，并就与行为疗法研究有关的问题向许多国家和国际政府组织和团体提供咨询，作为心理治疗研究的国家资源。在过去的4年里，我们的研究越来越多地集中在检查执行功能受损和冲动作为成瘾的基本组成部分和作为干预的潜在目标的作用。这项工作需要扩大我们的神经认知评估电池，并将创新的功能磁共振成像神经成像范式的试点和组件研究。在更新期间，研究将继续围绕一个核心设施和3个组成项目的阶段模型组织。核心工作人员将监督一项雄心勃勃的试点研究计划，并为中心项目提供科学监督、管理、标准化心理和神经生物学评估以及技术援助，同时沿着为其他研究中心的研究人员和临床医生提供咨询和援助。三项II期后期临床试验将检查（1）CBT 4CBT与认知增强药物的结合，（2）基于奖励的CM治疗可卡因依赖的最佳顺序，以及（3）在基于学校的戒烟计划中将基于学校的CM与尼古丁替代疗法相结合。 中心特征