Exploring the Fuel-Mediated Programming of Neonatal Growth

探索燃料介导的新生儿生长规划

• 批准号: 8520293
• 负责人: Dana Dabelea
• 金额: $ 66.21万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2014-09-22
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8520293
• 关键词: 15 year old; Address; Age; Air; Behavior; Biochemical Markers; Biological Markers; Birth Weight; Blood; Blood Glucose; Blood Vessels; Blood specimen; Body Composition; Body Size; Body mass index; Cardiovascular Abnormalities; Cardiovascular Diseases; Child; Chronic Disease; Clinical; Cohort Studies; Data; Deposition; Development; Diabetes Mellitus; Diagnosis; Diagnostic; Diet; Discipline of obstetrics; Dual-Energy X-Ray Absorptiometry; Energy Intake; Enrollment; Environment; Ethnic group; Etiology; Event; Exposure to; Fasting; Fatty acid glycerol esters; Fetal Growth; Fetus; Future; Generations; Genetic; Gestational Age; Gestational Diabetes; Glucose; Goals; Growth; High Density Lipoprotein Cholesterol; High birth weight infant; Homeostasis; Hour; Hyperglycemia; Hyperinsulinism; Infant; Inflammation; Inflammatory; Insulin; Insulin Resistance; Intake; Interleukin-6; International; Intervention; Lead; Leptin; Life; Lipids; Longitudinal Studies; Maternal Age; Maternal Exposure; Measurement; Measures; Mediating; Mediation; Mediator of activation protein; Metabolic; Metabolic Marker; Metabolism; Modeling; Mothers; National Children' s Study; Neonatal; Newborn Infant; Nonesterified Fatty Acids; Nutrient; Obesity; Organ; Outcome; Outcome Study; Overweight; Parents; Participant; Perinatal Exposure; Persons; Physical activity; Plethysmography; Population; Predisposition; Pregnancy; Pregnancy Outcome; Pregnant Women; Prevalence; Prevention strategy; Prospective Studies; Protocols documentation; Public Health; Reporting; Research; Research Design; Risk; Risk Factors; Role; Sample Size; Sampling; Structure; Testing; Time; Tissues; Triglycerides; Tumor Necrosis Factor-alpha; United Kingdom; United States; Visit; Weight Gain; Woman; abdominal fat; body system; cohort; design; disorder prevention; fetal; fetal programming; follow-up; glucose tolerance; high risk; in utero; indexing; infancy; infant monitoring; infant outcome; inflammatory marker; insulin secretion; mother nutrition; novel; nutrition; obesity risk; offspring; parity; postnatal; pregnant; programs; prospective; racial and ethnic; restraint; saturated fat; socioeconomics

Project Summary The overarching goal of this proposal is to establish and follow a cohort of ethnically diverse pregnant women and their offspring in order to longitudinally explore the hypothesis that fetal over-nutrition is associated with obesity, metabolic and cardio- vascular abnormalities in offspring. As part of the current application, we propose to test the hypothesis that programming of neonatal adiposity is driven by maternal obesity per se, in the absence of frank gestational diabetes. To determine whether there are associations between specific maternal factors and neonatal outcomes we will examine the effects of maternal obesity, diet and weight gain during pregnancy, together with specific potential mediators measured prospectively throughout pregnancy (maternal fuels, markers of insulin-resistance and inflammation). These are factors that can be targeted by future interventions. We propose to enroll a total of 1,920 pregnant women before 15 weeks of gestation and follow them prospectively through delivery in order to explore the relationships between maternal body size and behaviors during pregnancy [pre-pregnant BMI, weight gain, diet], intra-partum fuels (glucose, lipids, FFA), markers of inflammation (IL-6, TNF-¿) and insulin resistance (HOMA-IR)], and infant body size (birth weight for gestational age), fatness (determined by air displacement plethysmography) and fat deposition (skinfolds). All women will have two fasting in- person visits, in early pregnancy (15-16 weeks of gestation, IPV1) and mid pregnancy (24-28 weeks of gestation, IPV2). This well characterized cohort of pregnant women will not only permit us to test important hypotheses related to programming of neonatal fatness (Aims 1 and 2), but will also be informative for the planned follow-up of the cohort of offspring assembled. To explore the relationships between maternal factors and infant metabolic markers, a random sample (N=300) of mother/infant pairs, enriched in women with GDM, will be selected to undergo a neonatal fasting blood draw protocol. Biomarkers traditionally associated with an increased risk of future cardiovascular disease, such as glucose, lipids (triglyceride, total and HDL-cholesterol, FFA), markers of insulin resistance (HOMA-IR) and insulin secretion, and markers of inflammation (TNF-¿, leptin) will be explored in these newborns (Aim 3).

项目摘要 该提案的总体目标是建立并遵循一系列种族 潜水孕妇及其后代，以纵向探索 假设胎儿过度营养与肥胖，代谢和心脏 - 后代血管异常。作为当前应用程序的一部分，我们建议测试 新生儿肥胖的编程是由孕产妇肥胖所驱动的。 SE，在没有坦率的妊娠糖尿病的情况下。确定是否有 特定材料因素与新生儿结果之间的关联我们将检查 孕产妇肥胖，饮食和体重增加在怀孕期间的影响以及 在整个怀孕期间都可以预期测量的特定潜在介体（母亲 燃料，胰岛素抵抗和炎症的标记）。这些是可以的因素 以未来的干预为目标。我们建议总共注册1,920名孕妇 妊娠15周之前，并通过交货前瞻性地关注它们 探索怀孕期间母体体型与行为之间的关系 [妊娠前BMI，体重增加，饮食]，良内燃料（葡萄糖，脂质，FFA），标记 炎症（IL-6，TNF-）和胰岛素抵抗（HOMA-IR）和婴儿体大小 （妊娠年龄的出生体重），肥胖（由空气位移确定 杂质描绘）和脂肪沉积（皮肤折原）。所有妇女都会有两个禁食 - 在怀孕初期（妊娠15-16周，IPv1）和怀孕中期的人来访 （妊娠24-28周，IPv2）。这个孕妇的特征良好 不仅允许我们检验与新生儿编程有关的重要假设 肥胖（目标1和2），但也将为计划的随访提供信息 组合的后代队列。探索母校因素之间的关系 和婴儿代谢标记，母亲/婴儿对的随机样本（n = 300），富含 在患有GDM的女性中，将选择接受新生儿空腹血液抽血方案。 传统上，生物标志物与未来心血管的风险增加有关 疾病，例如葡萄糖，脂质（甘油三酸酯，总和HDL-胆固醇，FFA），标记物 胰岛素抵抗（HOMA-IR）和胰岛素分泌，以及炎症的标志 （TNF-®，瘦素）将在这些新生儿中进行探索（AIM 3）。