A New Translational Tool for Studying the Role of Breathing in Meditation.

摘要 呼吸练习，单独或作为身心干预的一个组成部分，如冥想和 瑜伽，有可能改善一系列的急性和慢性疾病。现在 提案描述了一种用于动态监测呼吸的新的转换工具的应用 对一种特殊的呼吸运动--意识呼吸(MB)--对一名主要 心血管危险因素血压(BP)。新的监视器可以进行连续测量， 不仅是呼吸率，而且是自然环境中呼出空气中的二氧化碳(PetCO2)，以及 诊所环境。与PetCO2相关的是，它与血液二氧化碳共同变化，后者反过来调节酸- 基础平衡，已知对所有身体组织中稳定的生理功能至关重要，因此 对健康很重要。 本项目提出了一项关于甲基溴对个体的二氧化碳分压、呼吸频率和血压的影响的研究 患有高血压前期。第一个具体目标是检验这样一个假设，即八周的MB计划 将产生比健康教育(HE)注意控制组更大的PetCO2变化。 第二个具体目标是检验MB将在24小时BP中产生更大降幅的假设 与HE相比，血压下降幅度更大的MB参与者将在 PetCO2比那些血压变化较小的人要高。新的监视器有能力向 参与者的呼吸发生了急剧的变化，改变了PetCO2。第三个具体问题 因此，本项目的目的是调查补充MB和HE训练的效果 在3个月的随访期内，PetCO2对BP的反馈。 这个项目有可能阐明MB或其他心身干预的机制 可以影响心血管疾病的主要危险因素，从而证明其适用性 这一新的翻译工具在CAM中进行研究。

Abstract Breathing exercises, alone or as a component of mind-body interventions such as meditation and yoga, have potential for amelioration of a wide range of acute and chronic disorders. The present proposal describes the application of a new translational tool for ambulatory monitoring of breathing to the investigation of the effects of a specific breathing exercise, mindful breathing (MB), on a major cardiovascular risk factor, blood pressure (BP). The new monitor enables continuous measurement, not only of breathing rate, but of CO2 in expired air (PetCO2) in the natural environment, as well as the clinic setting. The relevance of PetCO2 is that it co-varies with blood CO2, which in turn regulates acid- base balance, known to be vital for stable physiological function in all bodily tissues, and thus important to health. The present project proposes a study of MB effects on PetCO2, breathing rate, and BP in individuals with prehypertension. A first specific aim is to test the hypothesis that an eight week program of MB will produce greater changes in PetCO2 than occur in a health education (HE) attention control group. A second specific aim is to test the hypothesis that MB will produce greater reductions in 24-hr BP levels than HE, and that MB participants with greater decreases in BP will show larger changes in PetCO2 than those with smaller BP changes. The new monitor has the capacity to provide feedback to participants when an acute change in breathing that alters PetCO2 has occurred. The third specific aim of this project is, therefore, to investigate the effect of supplementing MB and HE training with PetCO2 feedback on BP during a 3-month follow-up period. This project has the potential to elucidate a mechanism by which MB or other mind-body interventions can influence a major risk factor for cardiovascular disease, and thereby demonstrate the applicability of this new translational tool to research in CAM.