A New Translational Tool for Studying the Role of Breathing in Meditation.

研究呼吸在冥想中的作用的新转化工具。

• 批准号: 8021962
• 负责人: MARGARET ANN CHESNEY
• 金额: $ 44.26万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8021962
• 关键词: Breathing; Meditation; Role; tool

DESCRIPTION (provided by applicant): Breathing exercises, alone or as a component of mind-body interventions such as meditation and yoga, have potential for amelioration of a wide range of acute and chronic disorders. The present proposal describes the application of a new translational tool for ambulatory monitoring of breathing to the investigation of the effects of a specific breathing exercise, mindful breathing (MB), on a major cardiovascular risk factor, blood pressure (BP). The new monitor enables continuous measurement, not only of breathing rate, but of CO2 in expired air (PetCO2) in the natural environment, as well as the clinic setting. The relevance of PetCO2 is that it co-varies with blood CO2, which in turn regulates acid base balance, known to be vital for stable physiological function in all bodily tissues, and thus important to health. The present project proposes a study of MB effects on PetCO2, breathing rate, and BP in individuals with prehypertension. A first specific aim is to test the hypothesis that an eight week program of MB will produce greater changes in PetCO2 than occur in a health education (HE) attention control group. A second specific aim is to test the hypothesis that MB will produce greater reductions in 24-hr BP levels than HE, and that MB participants with greater decreases in BP will show larger changes in PetCO2 than those with smaller BP changes. The new monitor has the capacity to provide feedback to participants when an acute change in breathing that alters PetCO2 has occurred. The third specific aim of this project is, therefore, to investigate the effect of supplementing MB and HE training with PetCO2 feedback on BP during a 3-month follow-up period. This project has the potential to elucidate a mechanism by which MB or other mind-body interventions can influence a major risk factor for cardiovascular disease, and thereby demonstrate the applicability of this new translational tool to research in CAM. PUBLIC HEALTH RELEVANCE: This research would provide the scientific community and the public with a new translational tool that could help advance our understanding of how various mind-body interventions, including breathing exercises, and meditation may impact health outcomes, including elevated blood pressure. This tool could be used in research to enhance the effectiveness of those interventions, and by doing so, contribute to public health.

描述（由申请人提供）：呼吸练习，单独或作为冥想和瑜伽等身心干预措施的一部分，有可能改善多种急性和慢性疾病。目前的提案描述了应用一种新的动态呼吸监测转化工具来调查特定呼吸练习（正念呼吸（MB））对主要心血管危险因素（血压（BP））的影响。新监测仪不仅可以连续测量呼吸频率，还可以连续测量自然环境和诊所环境中呼出空气中的二氧化碳 (PetCO2)。 PetCO2 的相关性在于它与血液二氧化碳共同变化，进而调节酸碱平衡，已知这对于所有身体组织的稳定生理功能至关重要，因此对健康很重要。本项目提议研究 MB 对高血压前期个体 PetCO2、呼吸频率和血压的影响。第一个具体目标是检验这样的假设：八周的 MB 计划将比健康教育 (HE) 注意力对照组产生更大的 PetCO2 变化。第二个具体目标是检验以下假设：MB 比 HE 更能降低 24 小时血压水平，并且血压降低幅度更大的 MB 参与者将比血压变化较小的参与者显示出更大的 PetCO2 变化。当呼吸发生急剧变化而改变 PetCO2 时，新的监测仪能够向参与者提供反馈。因此，该项目的第三个具体目标是研究在 3 个月的随访期间用 PetCO2 反馈补充 MB 和 HE 训练对血压的影响。该项目有可能阐明 MB 或其他身心干预措施影响心血管疾病主要危险因素的机制，从而证明其适用性 将此新的转化工具用于 CAM 的研究。 公共健康相关性：这项研究将为科学界和公众提供一种新的转化工具，有助于加深我们对各种身心干预措施（包括呼吸练习和冥想）如何影响健康结果（包括血压升高）的理解。该工具可用于研究，以提高这些干预措施的有效性，并通过这样做为公共卫生做出贡献。