A Hub for the Nuclear Receptor Signaling Atlas1

核受体信号图谱的枢纽1

• 批准号: 8546381
• 负责人: RONALD M EVANS
• 金额: $ 159.75万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-17 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8546381
• 关键词: Academia; Achievement; Androgen Receptor; Anthelmintics; Atlases; Bioinformatics; Cells; Circadian Rhythms; Communities; Complex; Computer software; Data Analyses; Data Set; Data Sources; Development; Diabetes Mellitus; Discipline; Disease; Endocrinology; Funding; Funding Mechanisms; Funding Opportunities; Gene Targeting; Generations; Genes; Genome; Genomics; Government; Hematology; Individual; Industry; Inflammation; Institutes; Internet; Investments; Journals; Literature; Macrophage Activation; Mails; Malignant Neoplasms; Measures; Metabolic Pathway; Metabolism; Methods; Metric; Molecular; Molecular Profiling; National Heart, Lung, and Blood Institute; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Environmental Health Sciences; Nature; Neurosciences; Nuclear Receptors; Obesity; Output; Paper; Peptides; Phage Display; Proteomics; Protocols documentation; PubMed; Publications; Publishing; Receptor Signaling; Regulation; Research; Research Personnel; Research Project Grants; Resources; Role; Science; Site; Software Tools; Techniques; Testing; Therapeutic; Time; Tissues; United States National Institutes of Health; Validation; Visit; Writing; base; bone; catalyst; cell growth regulation; chromatin modification; epigenomics; inhibitor/antagonist; member; metabolomics; nervous system disorder; novel; outreach; programs; promoter; protein protein interaction; public health relevance; response; senescence; small molecule; sound; success; therapeutic target; tool; transcriptomics; tumor metabolism; user-friendly; web site

DESCRIPTION (provided by applicant): Over the past decade the field of NR signaling has generated a large volume of global datasets that collectively describe sequences of NR and coregulator genes (genomics); the regulation by NRs and coregulators of gene networks in specific target tissues (transcriptomics); protein-protein interactions required for the efficient function of NRs and coregulators (proteomics); specific sites of action of NRs in target gene promoters (cistromics); covalent modification of chromatin (epigenomics); and, more recently, specific functional endpoints in the form of regulation of cellular metabolic pathways (metabolomics). In order to effectively leverage these resources, we propose the continued development of the Nuclear Receptor Signaling Atlas (NURSA) web resource that will assemble and integrate these datasets, build user-friendly data analysis tools and present these to the community for hypothesis generation and validation. To fully engage the research community, we propose to administer a program of NURSA Data Source Projects (NDSPs) that will generate new global scale datasets that will be submitted to the website and integrated with existing datasets. We will also engage in outreach efforts that will offer members of the research community to participate in NURSA as Affiliate members, as well as in testing software tools during their development. With the involvement of the community, we anticipate that NURSA will be an important research resource for this field.

描述（由申请人提供）：在过去的十年中，NR信号传导领域已经产生了大量的全球数据集，其共同描述了NR和共调节基因的序列（基因组学）;特定靶组织中基因网络的NR和辅助调节因子的调节（转录组学）; NR和辅调节因子有效发挥作用所需的蛋白质-蛋白质相互作用这些研究包括：蛋白质组学（蛋白质组学）;靶基因启动子中NR的特定作用位点（顺式异构体）;染色质的共价修饰（表观基因组学）;以及最近以细胞代谢途径调节形式的特定功能终点（代谢组学）。为了有效地利用这些资源，我们建议继续开发核受体信号图谱（Nuclear Receptor Signaling Atlas，简称CRISSA）网络资源，该网络资源将汇集和整合这些数据集，构建用户友好的数据分析工具，并将其提交给社区进行假设生成和验证。为了充分吸引研究界的参与，我们建议管理NURSA数据源项目（NDSP）计划，该计划将生成新的全球规模数据集，这些数据集将提交到网站并与现有数据集集成。我们还将参与外展工作，为研究社区的成员提供作为附属成员参与CIMSA的机会，并在开发过程中测试软件工具。随着社区的参与，我们预计，CIMSA将成为这一领域的重要研究资源。