A Hub for the Nuclear Receptor Signaling Atlas1

描述（由申请人提供）：在过去的十年中，NR信号领域已经产生了大量的全球数据集，这些数据集共同描述了NR和协同调节基因的序列（基因组学）；特异靶组织中基因网络的调控（转录组学）；NRs和协同调节因子有效功能所需的蛋白质-蛋白质相互作用（蛋白质组学）；NRs在靶基因启动子中的特定作用位点（噬细胞）；染色质共价修饰（表观基因组学）；最近，以调节细胞代谢途径（代谢组学）的形式出现了特定的功能终点。为了有效地利用这些资源，我们建议继续开发核受体信号图谱（NURSA）网络资源，该资源将收集和整合这些数据集，构建用户友好的数据分析工具，并将这些数据提供给社区进行假设生成和验证。为了充分参与研究界，我们建议管理NURSA数据源项目（ndsp）计划，该计划将生成新的全球规模数据集，这些数据集将提交给网站并与现有数据集集成。我们还将开展外联工作，为研究社区的成员提供作为附属成员参与NURSA的机会，并在软件工具开发过程中对其进行测试。随着社区的参与，我们预计NURSA将成为该领域的重要研究资源。

DESCRIPTION (provided by applicant): Over the past decade the field of NR signaling has generated a large volume of global datasets that collectively describe sequences of NR and coregulator genes (genomics); the regulation by NRs and coregulators of gene networks in specific target tissues (transcriptomics); protein-protein interactions required for the efficient function of NRs and coregulators (proteomics); specific sites of action of NRs in target gene promoters (cistromics); covalent modification of chromatin (epigenomics); and, more recently, specific functional endpoints in the form of regulation of cellular metabolic pathways (metabolomics). In order to effectively leverage these resources, we propose the continued development of the Nuclear Receptor Signaling Atlas (NURSA) web resource that will assemble and integrate these datasets, build user-friendly data analysis tools and present these to the community for hypothesis generation and validation. To fully engage the research community, we propose to administer a program of NURSA Data Source Projects (NDSPs) that will generate new global scale datasets that will be submitted to the website and integrated with existing datasets. We will also engage in outreach efforts that will offer members of the research community to participate in NURSA as Affiliate members, as well as in testing software tools during their development. With the involvement of the community, we anticipate that NURSA will be an important research resource for this field.