Expansion of NURSA Transcriptomine Annotation

在过去的十年中，NR信令领域产生了大量的全球数据集， 共同描述NR和辅助调节基因的序列(基因组学)；NRS和 特定靶组织中基因网络的共同调节(转录组学)；蛋白质-蛋白质相互作用 NRs和核心调节因子(蛋白质组学)的有效功能所必需的；NRs在 靶基因启动子(Cstromics)；染色质的共价修饰(表观基因组学)；以及最近， 以调节细胞代谢途径的形式出现的特定功能终点(代谢组学)。按顺序 为了有效地利用这些资源，我们建议继续开发核受体 信令地图集(NURSA)Web资源，将汇集和集成这些数据集，构建用户友好型 数据分析工具，并将这些工具提供给社区以用于假设生成和验证。充分地 参与研究社区，我们建议管理一个NURSA数据源项目 (NDSP)将生成新的全球尺度数据集，这些数据集将提交到网站并进行整合 使用现有的数据集。我们还将参与外展工作，为研究人员提供 社区以附属成员的身份参与NURSA，并在其 发展。在社区的参与下，我们预计Nursa将成为一个重要的 这一领域的研究资源。 相关性(请参阅说明)： 核受体(NRs)和辅助调节因子是许多不同疾病状态的重要治疗靶点 包括癌症、肥胖症、糖尿病、炎症、神经疾病和老年性疾病。这 应用程序建议为NR研究社区提供信息和数据分析工具的Web资源， 以及一个社区研究资助计划，该计划将为 通过网络资源进行分发。这些举措将对#年的研究进展产生实实在在的好处 开发基于NR和辅助调节子的新型治疗药物的领域。

Over the past decade the field of NR signaling has generated a large volume of global datasets that collectively describe sequences of NR and coregulator genes (genomics); the regulation by NRs and coregulators of gene networks in specific target tissues (transcriptomics); protein-protein interactions required for the efficient function of NRs and coregtjiators (proteomics); specific sites of action of NRs in target gene promoters (cistromics); covalent modification of chromatin (epigenomics); and, more recently, specific functional endpoints in the form of regulation of cellular metabolic pathways (metabolomics). In order to effectively leverage these resources, we propose the continued development ofthe Nuclear Receptor Signaling Atlas (NURSA) web resource that will assemble and integrate these datasets, build user-friendly data analysis tools and present these to the community for hypothesis generation and validation. To fully engage the research community, we propose to administer a program of NURSA Data Source Projects (NDSPs) that will generate new global scale datasets that will be submitted to the website and integrated with existing datasets. We will also engage in outreach efforts that will offer members of the research community to participate in NURSA as Affiliate members, as well as in testing software tools during their development. With the involvement of the community, we anticipate that NURSA will be an important research resource for this field. RELEVANCE (See instructions): Nuclear receptors (NRs) and coregulators are important therapeutic targets in many different disease states including cancer, obesity, diabetes, inflammation, neurological disorders and senescent diseases. This application proposes a web resource for information and data analysis tools for the NR research community, as well as a community research grant program that will generate global-scale 'omics datasets for distribution via the web resource. These initiatives will have tangible benefits for the progress of research in the field towards developing novel NR- and coregulator-based therapeutics.