A Hub for the Nuclear Receptor Signaling Atlas1

描述(申请人提供)：在过去的十年里，NR信号转导领域产生了大量的全球数据集，这些数据集共同描述了NR和辅助调节基因的序列(基因组学)；NRs和辅助调节因子在特定靶组织中基因网络的调节(转录组学)；NRs和辅助调节因子高效发挥功能所需的蛋白质-蛋白质相互作用(蛋白质组学)；NRs在靶基因启动子中的特定作用位点(Cstromics)；染色质的共价修饰(表观基因组学)；以及最近以细胞代谢途径调节形式的特定功能终点(代谢组学)。为了有效地利用这些资源，我们建议继续开发核受体信号图集(NURSA)网络资源，该资源将汇编和整合这些数据集，建立用户友好的数据分析工具，并将这些工具提供给社区用于假设生成和验证。为了让研究界充分参与，我们提议管理一项NURSA数据源项目(NDSP)计划，该计划将生成新的全球范围的数据集，这些数据集将提交到网站并与现有数据集集成。我们还将参与外展工作，为研究社区的成员提供参与NURSA的附属成员，以及在他们的开发过程中测试软件工具。随着社区的参与，我们预计Nursa将成为这一领域的重要研究资源。

DESCRIPTION (provided by applicant): Over the past decade the field of NR signaling has generated a large volume of global datasets that collectively describe sequences of NR and coregulator genes (genomics); the regulation by NRs and coregulators of gene networks in specific target tissues (transcriptomics); protein-protein interactions required for the efficient function of NRs and coregulators (proteomics); specific sites of action of NRs in target gene promoters (cistromics); covalent modification of chromatin (epigenomics); and, more recently, specific functional endpoints in the form of regulation of cellular metabolic pathways (metabolomics). In order to effectively leverage these resources, we propose the continued development of the Nuclear Receptor Signaling Atlas (NURSA) web resource that will assemble and integrate these datasets, build user-friendly data analysis tools and present these to the community for hypothesis generation and validation. To fully engage the research community, we propose to administer a program of NURSA Data Source Projects (NDSPs) that will generate new global scale datasets that will be submitted to the website and integrated with existing datasets. We will also engage in outreach efforts that will offer members of the research community to participate in NURSA as Affiliate members, as well as in testing software tools during their development. With the involvement of the community, we anticipate that NURSA will be an important research resource for this field.