Neuroimaging Core

神经影像核心

• 批准号: 8510689
• 负责人: EINAR MENCL
• 金额: $ 15.73万
• 依托单位: HASKINS LABORATORIES, INC.
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8510689
• 关键词: Automation; Boxing; Code; Communication; Competence; Computer software; Computers; Data; Data Analyses; Development; Electroencephalography; Event; Event-Related Potentials; Fostering; Functional Magnetic Resonance Imaging; Goals; Housing; Human Resources; Image; Instruction; Laboratories; Language; Life; Linux; Magnetic Resonance Imaging; Medical; Methodology; Nature; Near-Infrared Spectroscopy; Neuroanatomy; Neurobiology; Outcome; Persons; Physics; Postdoctoral Fellow; Procedures; Process; Program Efficiency; Quality Control; Research Personnel; Resources; Running; Scientist; Site; Speech; Standardization; Techniques; Testing; Training; Writing; computerized data processing; data acquisition; design; imaging modality; meetings; neuroimaging; programs; research study; response

The Neuroimaging Core (Core B, NC) will provide expertise and support for acquisition and analysis of structural and functional Magnetic Resonance Imaging (sMRI/fMRI), functional Near-Infrared Spectroscopy (NIRS), and electroencephalography/event related potentials (EEG/ERP). By providing a centralized organizatlon for use of these techniques across multiple Projects, the NC will greatly increase efficiency of the Program as a whole by eliminating redundancy and providing common processing procedures and automation. Further, it will enable comparability across Projects and sites, by providing standardization in acquisition and analysis. The speciflc strengths of the Core Director and Invesflgators support each methodology: key personnel include experts Dr. Einar Mend, Core Director (structural and funcflonal MRI); Dr. Nicole Landi (EEG/ERP); and Heather Bortfeld (NIRS). Select consultants provide additional expertise: Dr. Robert Fulbright (neuroanatomy and medical review); Dr. Todd Constable (MR physics); and Dr. Ching-Po Lin (flbertract.imaging using DTI and DSI). Computaflonal resources are extensive, including multiple Linux and PC boxes, and a 40-core Mac Xgrid network running all necessary MR software packages and in-house developed Maflab programs. ERP and NIRS data processing are supported by dedicated Macintosh Pro computers. The NC will maintain wikis for communication and QC across sites, and provide local (weekly in person) and global (monthly via Skype) meetings for relevant staff and scientists. The NC will instantiate and maintain quality control and comparability of data acquisitions within each technique, across the multiple sites. As needed, NC staff will provide training of scientists and research associates across Projects in data acquisition and analysis. The NC will provide support for the proper design of experiments to take advantage of the particular strengths of each imaging modality. NC staff will preprocess and perform initial subject-level analysis for all MRI data collected at Haskins Laboratories, and provide support to Project scientists performing main across-subjects analyses for hypothesis testing. Finally, the NC staff will actively develop new techniques for acquisition and analysis to support the scientific goals of the Project.

神经成像核心（Core B，NC）将为结构和功能磁共振成像（sMRI/fMRI）、功能近红外光谱（NIRS）和脑电图/事件相关电位（EEG/ERP）的采集和分析提供专业知识和支持。通过为多个项目使用这些技术提供一个集中的组织，NC将通过消除冗余和提供通用的处理程序和自动化来大大提高整个程序的效率。此外，通过提供采集和分析的标准化，它将实现项目和地点之间的可比性。核心总监和研究者的特殊优势支持每种方法：关键人员包括专家Einar Mend博士，核心总监（结构和功能MRI）; Nicole Landi博士（EEG/ERP）;和石楠波特菲尔德（NIRS）。精选顾问提供额外的专业知识：罗伯特富布赖特博士（神经解剖学和医学评论）;托德康斯特布尔博士（磁共振物理学）;和林清波博士（纤维束成像使用DTI和DSI）。Computaflonal资源广泛，包括多个Linux和PC机盒，以及运行所有必要MR软件包和内部开发的Maflab程序的40核Mac Xgrid网络。ERP和NIRS数据处理由专用的Macintosh Pro计算机支持。NC将维护用于跨研究中心沟通和质量控制的wiki，并为相关工作人员和科学家提供本地（每周亲自）和全球（每月通过Skype）会议。NC将在多个研究中心实施并维护每种技术内数据采集的质量控制和可比性。根据需要，NC工作人员将为科学家和研究助理提供培训， 数据采集和分析项目。NC将为适当的实验设计提供支持，以利用每种成像模式的特定优势。NC工作人员将对Haskins实验室收集的所有MRI数据进行预处理和初始受试者水平分析，并为项目科学家进行假设检验的主要跨受试者分析提供支持。最后，NC工作人员将积极开发新的采集和分析技术，以支持项目的科学目标。