Training in Schizophrenia and Psychotic Disorders: From Animal Models to Patients

说明（由申请人提供）：本申请为精神分裂症研究奖学金T32-MH018870的续期申请，该奖学金自1988年以来一直获得资助。该提案的主要目标是培养博士后（医学博士、医学博士/博士和博士），使其成为精神分裂症领域的独立研究人员。一个密集的为期三年的项目概述，研究员将学习如何识别关键的研究问题，制定假设，设计和执行实验，有效地测试这些假设。在培训过程中，研究员将获得一系列与研究方法相关的技能，包括与基础、转化和临床研究项目相关的实验设计和统计分析方面的专业知识。毕业生将能够以书面和口头形式清楚地展示整个项目，并通过出版物和演示来证明。培训计划的成功与否最好从我们以前的学员的卓越成就来判断。在过去的10年里，有27名研究员被选中进入培训计划，其中55%是博士，30%是博士/博士，15%是博士。59%的受训者是女性。未来的研究员专门申请这个项目，培训名额的竞争仍然很激烈。26%的研究员是从哥伦比亚精神病学住院医师项目中招募的。近10年（21/21）奖学金毕业率100%。目前有六名研究员：一名四年研究员（因复杂的怀孕和产假而特别豁免）、一名三年级研究员、两名二年级研究员和两名第一年研究员；四名新研究员已被接受在2009年底前开始。在过去10年毕业的21名研究员中，11名（52%）获得了K奖，目前有两名K奖申请正在接受现任研究员的审查。两名毕业生（10%）已经收到r01，另外两名收到r21 (roi和r21的总数为19%)，还有几名毕业生正在申请中。总共有18名（86%）毕业生获得了大量的独立资助，包括roi， K奖，R03奖，R21奖，NARSAD奖，以及海军研究办公室和其他资助机构的资助。在该项目毕业的21名研究员中，有16名（76%）担任全职学术研究职位。如果培训项目停滞不前，就不可能保持成功的记录；它必须适应环境的变化和精神病学转化研究方面不断增长的机会。在翻译研究的培训已显著加强，通过提高教学计划，并通过战略增加教师导师在这一领域。这个培训项目最大的优势一直是哥伦比亚大学精神病学系内外的师资力量和研究环境。今天的情况仍然如此，培训计划的核心已经通过当前应用程序的变化得到了加强。

DESCRIPTION (provided by applicant): This is an application for renewal of grant T32-MH018870, Schizophrenia Research Fellowship, which has been funded continuously since 1988. The primary goal of this proposal is to train postdoctoral (MD, MD/PhD and PhD) fellows for careers as independent researchers in Schizophrenia. An intensive three-year program is outlined in which fellows will learn how to identify key research questions, formulate hypotheses, and design and execute experiments that effectively test those hypotheses. In the course of training, fellows will acquire a range of skills relevant to research methodology, including expertise in experimental design and statistical analysis relevant to basic, translational and clinical research programs. Graduating fellows will be able to present clearly an entire project in both written and oral form as evidenced by publications and presentations. The success of the training program is best judged by the remarkable accomplishments of our former trainees. In the past 10 years, 27 fellows have been selected to enter the training program, 55% MDs, 30% MD/PhDs and 15% PhDs. 59% of our trainees have been women. Prospective fellows apply specifically to this program, and the competition for training slots remains intense. 26% of fellows have been recruited from the Columbia Psychiatry Residency program. The graduation rate of the fellowship is 100% over the last 10 years (21/21). Currently, there are six fellows: one fourth-year (special waiver related to a complicated pregnancy and maternity leave), one third-year, two second-year and 2 in the first year of training; four new fellows have been accepted to begin before the end of 2009. Of the 21 fellows who have graduated the program in the past 10 years, 11 (52%) have received K awards and two K award submissions are presently under review from current fellows. Two graduates (10%) have already received R01s with another two receiving R21s (total of 19% for both ROIs and R21s), and several others have applications pending. In total, 18 (86%) graduates have received substantial independent funding including ROIs, K awards, R03 awards, R21 awards, NARSAD awards, and grants from the Office of Naval Research and other funding agencies. Of the 21 fellows who graduated the program, 16 (76%) are in full-time academic research positions. No training program can maintain a successful track record if it remains stagnant; it must adapt to changes in circumstances and the growing opportunities in terms of translational research in Psychiatry. The training in translational research has been markedly strengthened by enhancement of the didactic teaching program and through the strategic addition of faculty mentors in this area. The greatest strengths of this training program have always been Columbia's faculty and the research environment within the Department of Psychiatry and beyond. This remains the case today, and the core of the training program has been strengthened by the changes in the current application.