Training in Schizophrenia and Psychotic Disorders: From Animal Models to Patients

项目摘要 本申请是为了更新资助5 T32 MH 018870，“精神分裂症和精神障碍的培训： 从动物模型到患者”，自1988年以来一直得到资助。目标是培养博士后（MD， MD/PhD和PhD）研究员作为独立研究人员的职业。我们目标的实现是通过 有多少研究员在K奖或其他来源的支持下继续从事研究密集型的研究 资金。在一个为期三年的密集计划，研究员学习确定关键的研究问题，制定 假设，并设计和执行测试这些假设的实验。研究员所需的其他技能 要成为一名独立的研究人员，包括了解成功研究的管理 企业、有效的协作和书面赠款。关于负责任行为的全面培训 研究在奖学金的早期就开始了。一个研究员必须保持最高标准的科学诚信， 了解与人类和动物研究相关的伦理问题。 培训计划的成功体现在受训人员的成就和 研究员的多样性。在过去15年中，有42名研究员被选中参加培训方案; 33% 女性，10%少数民族，33%医学博士，29%医学博士/博士和38%博士，其中29%来自哥伦比亚精神病医院 居住计划和71%来自外部。在过去的10年里，由于我们加强了少数族裔的招聘， 努力和利维奖学金对我们招募学员的能力的影响，我们已经招募了15%的少数民族 和38%的非白人和/或非欧洲血统，从哥伦比亚居住招募的部分， 上升到42%。此外，我们的MD/PhD比例在过去10年中增加到31%。的 在过去的15年里，奖学金的毕业率为97%（31/32）;一个没有毕业的人离开了 经过一年的研究，将研究结果转化为精神卫生政策和实践， 在纽约心理健康办公室担任临床管理职位，实施他的研究，我们也 认为是成功的。在这些毕业生中，94%的人继续从事研究工作，70%的人从事研究密集型工作 24%的人从事研究工作。在去年毕业的31名研究员中， 15年来，69%的人获得了K奖。在5年前毕业的人中，62%的人获得了 R级资金来自NIH，72%获得了主要的联邦资金（NIH或国防部）， 95%的人获得过一项或多项研究赠款（包括基金会资助）。目前 有8名研究员：2名第三年，2名第二年，4名第一年培训;一名研究员已被接受， 开始于2019年7月。

Project Summary This application is for renewal of grant 5T32MH018870, “Training in Schizophrenia and Psychotic Disorders: From Animal Models to Patients”, that has been funded since 1988. The goal is to train postdoctoral (MD, MD/PhD, and PhD) fellows for careers as independent researchers. Achievement of our goal is measured by how many fellows continue in a research-intensive trajectory whether supported by a K award or other sources of funding. During an intensive three-year program, fellows learn to identify key research questions, formulate hypotheses, and design and execute experiments that test those hypotheses. Other skills required for a fellow to become an independent researcher include understanding the administration of a successful research enterprise, effective collaboration and writing grants. Comprehensive training in the Responsible Conduct of Research begins early in the fellowship. A fellow must maintain the highest standards of scientific integrity and understand the ethical issues relevant to human and animal research. The success of the training program is reflected in both the accomplishments of the trainees and in the diversity of the fellows. In the past 15 years, 42 fellows have been selected to enter the training program; 33% female, 10% minorities, 33% MDs, 29% MD/PhDs and 38% PhDs, with 29% from the Columbia Psychiatric Residency program and 71% from outside. Over the past 10 years, due to our enhanced minority recruitment efforts and the impact of the Levy Fellowship on our ability to recruit trainees, we have recruited 15% minorities and 38% of non-white and/or non-European descent, and the fraction recruited from the Columbia residency has climbed to 42%. Furthermore, our fraction of MD/PhDs has increased to 31% over the past 10 years. The graduation rate of the fellowship is 97% over the last 15 years (31/32); the one fellow who did not graduate left after 1 year of research on the translation of research findings into mental health policy and practice to pursue a clinical administration position in the New York Office of Mental Health implementing his research, which we also consider a success. Of these graduates, 94% have remained in research, with 70% in research-intensive positions and 24% in research-related positions. Of the 31 fellows who have graduated the program in the last 15 years, 69% have been awarded K awards. Of those who graduated more than 5 years ago, 62% have received R-level funding from the NIH, 72% have received major federal funding (NIH or Department of Defense), and 95% have received one or more research grants of some kind (including foundation support). Currently, there are 8 fellows: 2 third-year, 2 second-year, and 4 in the first year of training; one fellow has been accepted to begin in July 2019.